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Volumn 61, Issue 5, 2010, Pages 466-472

The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells

Author keywords

Airway hyperresponsiveness; IL 13; NF B; RhoA; STAT6; TNF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; LUCIFERASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 77950629897     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.12.001     Document Type: Article
Times cited : (38)

References (46)
  • 1
    • 0028987597 scopus 로고
    • 2+ availability involved in antigen-induced airway hyperresponsiveness in rats
    • 2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur J Pharmacol 1995, 278:79-82.
    • (1995) Eur J Pharmacol , vol.278 , pp. 79-82
    • Chiba, Y.1    Misawa, M.2
  • 2
    • 0027969286 scopus 로고
    • 2+-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells
    • 2+-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells. J Clin Invest 1994, 944:1397-1403.
    • (1994) J Clin Invest , vol.944 , pp. 1397-1403
    • Satoh, S.1    Kreutz, R.2    Wilm, C.3    Ganten, D.4    Pfitzer, G.5
  • 4
    • 0030725480 scopus 로고    scopus 로고
    • Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle
    • Bremerich D.H., Warner D.O., Lorenz R.R., Shumway R., Jones K.A. Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle. Am J Physiol 1997, 273:L775-781.
    • (1997) Am J Physiol , vol.273
    • Bremerich, D.H.1    Warner, D.O.2    Lorenz, R.R.3    Shumway, R.4    Jones, K.A.5
  • 5
    • 0035823116 scopus 로고    scopus 로고
    • Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats
    • Chiba Y., Takeyama H., Sakai H., Misawa M. Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur J Pharmacol 2001, 427:77-82.
    • (2001) Eur J Pharmacol , vol.427 , pp. 77-82
    • Chiba, Y.1    Takeyama, H.2    Sakai, H.3    Misawa, M.4
  • 6
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003, 83:1325-1358.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 7
    • 1642545654 scopus 로고    scopus 로고
    • Upregulation of RhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats
    • Chiba Y., Sakai H., Wachi H., Sugitani H., Seyama Y., Misawa M. Upregulation of RhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats. J Smooth Muscle Res 2003, 39:221-228.
    • (2003) J Smooth Muscle Res , vol.39 , pp. 221-228
    • Chiba, Y.1    Sakai, H.2    Wachi, H.3    Sugitani, H.4    Seyama, Y.5    Misawa, M.6
  • 8
    • 59149107299 scopus 로고    scopus 로고
    • Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein
    • Chiba Y., Nakazawa S., Todoroki M., Shinozaki K., Sakai H., Misawa M. Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein. Am J Respir Cell Mol Biol 2009, 40:159-167.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 159-167
    • Chiba, Y.1    Nakazawa, S.2    Todoroki, M.3    Shinozaki, K.4    Sakai, H.5    Misawa, M.6
  • 9
    • 0035316139 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension
    • Mukai Y., Shimokawa H., Matoba T., Kandabashi T., Satoh S., Hiroki J., et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J 2001, 15:1062-1064.
    • (2001) FASEB J , vol.15 , pp. 1062-1064
    • Mukai, Y.1    Shimokawa, H.2    Matoba, T.3    Kandabashi, T.4    Satoh, S.5    Hiroki, J.6
  • 10
    • 0037423816 scopus 로고    scopus 로고
    • Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
    • Seko T., Ito M., Kureishi Y., Okamoto R., Moriki N., Onishi K., et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 2003, 92:411-418.
    • (2003) Circ Res , vol.92 , pp. 411-418
    • Seko, T.1    Ito, M.2    Kureishi, Y.3    Okamoto, R.4    Moriki, N.5    Onishi, K.6
  • 11
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997, 389:990-994.
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3    Ono, T.4    Kawahara, T.5    Morishita, T.6
  • 12
    • 0032877847 scopus 로고    scopus 로고
    • Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
    • Shimokawa H., Seto M., Katsumata N., Amano M., Kozai T., Yamawaki T., et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 1999, 43:1029-1039.
    • (1999) Cardiovasc Res , vol.43 , pp. 1029-1039
    • Shimokawa, H.1    Seto, M.2    Katsumata, N.3    Amano, M.4    Kozai, T.5    Yamawaki, T.6
  • 13
    • 0034696624 scopus 로고    scopus 로고
    • Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta
    • Kandabashi T., Shimokawa H., Miyata K., Kunihiro I., Kawano Y., Fukata Y., et al. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 2000, 101:1319-1323.
    • (2000) Circulation , vol.101 , pp. 1319-1323
    • Kandabashi, T.1    Shimokawa, H.2    Miyata, K.3    Kunihiro, I.4    Kawano, Y.5    Fukata, Y.6
  • 14
    • 0035957574 scopus 로고    scopus 로고
    • Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C
    • Chrissobolis S., Sobey C.G. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C. Circ Res 2001, 88:774-779.
    • (2001) Circ Res , vol.88 , pp. 774-779
    • Chrissobolis, S.1    Sobey, C.G.2
  • 15
    • 0033879562 scopus 로고    scopus 로고
    • Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
    • Sato M., Tani E., Fujikawa H., Kaibuchi K. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 2000, 87:195-200.
    • (2000) Circ Res , vol.87 , pp. 195-200
    • Sato, M.1    Tani, E.2    Fujikawa, H.3    Kaibuchi, K.4
  • 16
    • 3142659551 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • Wills-Karp M. Interleukin-13 in asthma pathogenesis. Curr Allergy Asthma Rep 2004, 4:123-131.
    • (2004) Curr Allergy Asthma Rep , vol.4 , pp. 123-131
    • Wills-Karp, M.1
  • 17
    • 7944237374 scopus 로고    scopus 로고
    • Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    • Berry M.A., Parker D., Neale N., Woodman L., Morgan A., Monk P., et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2004, 114:1106-1109.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1106-1109
    • Berry, M.A.1    Parker, D.2    Neale, N.3    Woodman, L.4    Morgan, A.5    Monk, P.6
  • 19
    • 0033856743 scopus 로고    scopus 로고
    • Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations
    • Prieto J., Lensmar C., Roquet A., van der Ploeg I., Gigliotti D., Eklund A., et al. Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations. Respir Med 2000, 94:806-814.
    • (2000) Respir Med , vol.94 , pp. 806-814
    • Prieto, J.1    Lensmar, C.2    Roquet, A.3    van der Ploeg, I.4    Gigliotti, D.5    Eklund, A.6
  • 20
    • 1642370744 scopus 로고    scopus 로고
    • Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts
    • Batra V., Musani A.I., Hastie A.T., Khurana S., Carpenter K.A., Zangrilli J.G., et al. Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin Exp Allergy 2004, 34:437-444.
    • (2004) Clin Exp Allergy , vol.34 , pp. 437-444
    • Batra, V.1    Musani, A.I.2    Hastie, A.T.3    Khurana, S.4    Carpenter, K.A.5    Zangrilli, J.G.6
  • 21
    • 0036088040 scopus 로고    scopus 로고
    • IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
    • Grunstein M.M., Hakonarson H., Leiter J., Chen M., Whelan R., Grunstein J.S., et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol 2002, 282:L520-528.
    • (2002) Am J Physiol , vol.282
    • Grunstein, M.M.1    Hakonarson, H.2    Leiter, J.3    Chen, M.4    Whelan, R.5    Grunstein, J.S.6
  • 22
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z., Homer R.J., Wang Z., Chen Q., Geba G.P., Wang J., et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103:779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 23
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman D.A., Huang X., Koth L.L., Chang G.H., Dolganov G.M., Zhu Z., et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002, 8:885-889.
    • (2002) Nat Med , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3    Chang, G.H.4    Dolganov, G.M.5    Zhu, Z.6
  • 24
    • 0035402376 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    • Laporte J.C., Moore P.E., Baraldo S., Jouvin M.H., Church T.L., Schwartzman I.N., et al. Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 2001, 164:141-148.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 141-148
    • Laporte, J.C.1    Moore, P.E.2    Baraldo, S.3    Jouvin, M.H.4    Church, T.L.5    Schwartzman, I.N.6
  • 25
    • 0028812580 scopus 로고
    • Tumour necrosis factor alpha: a potential mediator of asthma
    • Shah A., Church M.K., Holgate S.T. Tumour necrosis factor alpha: a potential mediator of asthma. Clin Exp Allergy 1995, 25:1038-1044.
    • (1995) Clin Exp Allergy , vol.25 , pp. 1038-1044
    • Shah, A.1    Church, M.K.2    Holgate, S.T.3
  • 27
    • 0009687511 scopus 로고
    • Tumor necrosis factor in sputa of patients with bronchial asthma on exacerbation
    • Taki F., Kondoh Y., Matsumoto K., Takagi K., Satake T., Taniguchi H., et al. Tumor necrosis factor in sputa of patients with bronchial asthma on exacerbation. Arerugi 1991, 40:643-646.
    • (1991) Arerugi , vol.40 , pp. 643-646
    • Taki, F.1    Kondoh, Y.2    Matsumoto, K.3    Takagi, K.4    Satake, T.5    Taniguchi, H.6
  • 28
    • 0027583806 scopus 로고
    • Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist
    • Watson M.L., Smith D., Bourne A.D., Thompson R.C., Westwick J. Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. Am J Respir Cell Mol Biol 1993, 8:365-369.
    • (1993) Am J Respir Cell Mol Biol , vol.8 , pp. 365-369
    • Watson, M.L.1    Smith, D.2    Bourne, A.D.3    Thompson, R.C.4    Westwick, J.5
  • 29
    • 0028989599 scopus 로고
    • TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation
    • Lukacs N.W., Strieter R.M., Chensue S.W., Widmer M., Kunkel S.L. TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation. J Immunol 1995, 154:5411-5417.
    • (1995) J Immunol , vol.154 , pp. 5411-5417
    • Lukacs, N.W.1    Strieter, R.M.2    Chensue, S.W.3    Widmer, M.4    Kunkel, S.L.5
  • 30
    • 0034581503 scopus 로고    scopus 로고
    • Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
    • Amrani Y., Chen H., Panettieri R.A. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?. Respir Res 2000, 1:49-53.
    • (2000) Respir Res , vol.1 , pp. 49-53
    • Amrani, Y.1    Chen, H.2    Panettieri, R.A.3
  • 31
    • 9344263478 scopus 로고    scopus 로고
    • Involvement of p42/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by TNF-alpha in rats
    • Sakai H., Otogoto S., Chiba Y., Abe K., Misawa M. Involvement of p42/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by TNF-alpha in rats. J Appl Physiol 2004, 97:2154-2159.
    • (2004) J Appl Physiol , vol.97 , pp. 2154-2159
    • Sakai, H.1    Otogoto, S.2    Chiba, Y.3    Abe, K.4    Misawa, M.5
  • 32
    • 0031816128 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro
    • Pennings H.J., Kramer K., Bast A., Buurman W.A., Wouters E.F. Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. Eur Respir J 1998, 12:45-49.
    • (1998) Eur Respir J , vol.12 , pp. 45-49
    • Pennings, H.J.1    Kramer, K.2    Bast, A.3    Buurman, W.A.4    Wouters, E.F.5
  • 34
    • 70349852575 scopus 로고    scopus 로고
    • Downregulation of miR-133a contributes to upregulation of RhoA in bronchial smooth muscle cells
    • Chiba Y., Tanabe M., Goto K., Sakai H., Misawa M. Downregulation of miR-133a contributes to upregulation of RhoA in bronchial smooth muscle cells. Am J Respir Crit Care Med 2009, 180:713-719.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 713-719
    • Chiba, Y.1    Tanabe, M.2    Goto, K.3    Sakai, H.4    Misawa, M.5
  • 35
    • 33845294438 scopus 로고    scopus 로고
    • Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors
    • Nagashima S., Yokota M., Nakai E., Kuromitsu S., Ohga K., Takeuchi M., et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem 2007, 15:1044-1055.
    • (2007) Bioorg Med Chem , vol.15 , pp. 1044-1055
    • Nagashima, S.1    Yokota, M.2    Nakai, E.3    Kuromitsu, S.4    Ohga, K.5    Takeuchi, M.6
  • 36
    • 62749177245 scopus 로고    scopus 로고
    • IL-13 induces translocation of NF-kappaB in cultured human bronchial smooth muscle cells
    • Goto K., Chiba Y., Misawa M. IL-13 induces translocation of NF-kappaB in cultured human bronchial smooth muscle cells. Cytokine 2009, 46:96-99.
    • (2009) Cytokine , vol.46 , pp. 96-99
    • Goto, K.1    Chiba, Y.2    Misawa, M.3
  • 37
    • 68849083521 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells
    • Goto K., Chiba Y., Sakai H., Misawa M. Tumor necrosis factor-alpha (TNF-alpha) induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells. J Pharmacol Sci 2009, 110:437-444.
    • (2009) J Pharmacol Sci , vol.110 , pp. 437-444
    • Goto, K.1    Chiba, Y.2    Sakai, H.3    Misawa, M.4
  • 38
    • 0036211424 scopus 로고    scopus 로고
    • Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma
    • Amrani Y., Panettieri R.A. Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma. Curr Opin Allergy Clin Immunol 2002, 2:39-45.
    • (2002) Curr Opin Allergy Clin Immunol , vol.2 , pp. 39-45
    • Amrani, Y.1    Panettieri, R.A.2
  • 39
    • 15244359887 scopus 로고    scopus 로고
    • Hyperresponsiveness of bronchial but not tracheal smooth muscle in a murine model of allergic bronchial asthma
    • Chiba Y., Ueno A., Sakai H., Misawa M. Hyperresponsiveness of bronchial but not tracheal smooth muscle in a murine model of allergic bronchial asthma. Inflamm Res 2004, 53:636-642.
    • (2004) Inflamm Res , vol.53 , pp. 636-642
    • Chiba, Y.1    Ueno, A.2    Sakai, H.3    Misawa, M.4
  • 41
    • 13444282306 scopus 로고    scopus 로고
    • 2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness
    • 2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. J Smooth Muscle Res 2004, 40:155-167.
    • (2004) J Smooth Muscle Res , vol.40 , pp. 155-167
    • Chiba, Y.1    Misawa, M.2
  • 43
    • 33646023979 scopus 로고    scopus 로고
    • Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma
    • Gosens R., Schaafsma D., Nelemans S.A., Halayko A.J. Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma. Mini Rev Med Chem 2006, 6:339-348.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 339-348
    • Gosens, R.1    Schaafsma, D.2    Nelemans, S.A.3    Halayko, A.J.4
  • 44
    • 0035313367 scopus 로고    scopus 로고
    • STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts
    • Hoeck J., Woisetschlager M. STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts. J Immunol 2001, 166:4507-4515.
    • (2001) J Immunol , vol.166 , pp. 4507-4515
    • Hoeck, J.1    Woisetschlager, M.2
  • 45
    • 0034976854 scopus 로고    scopus 로고
    • Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism
    • Matsukura S., Stellato C., Georas S.N., Casolaro V., Plitt J.R., Miura K., et al. Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Am J Respir Cell Mol Biol 2001, 24:755-761.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 755-761
    • Matsukura, S.1    Stellato, C.2    Georas, S.N.3    Casolaro, V.4    Plitt, J.R.5    Miura, K.6
  • 46
    • 0038660670 scopus 로고    scopus 로고
    • Rhoa expression is controlled by nitric oxide through cGMP-dependent protein kinase activation
    • Sauzeau V., Rolli-Derkinderen M., Marionneau C., Loirand G., Pacaud P. Rhoa expression is controlled by nitric oxide through cGMP-dependent protein kinase activation. J Biol Chem 2003, 278:9472-9480.
    • (2003) J Biol Chem , vol.278 , pp. 9472-9480
    • Sauzeau, V.1    Rolli-Derkinderen, M.2    Marionneau, C.3    Loirand, G.4    Pacaud, P.5


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