Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells

Molecular Immunology

Volumn 47, Issue 7-8, 2010, Pages 1383-1395

  Luo, Hong ^a   Tian, Ming ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

B cells; Chicken; Immunoglobulin; Recombination; Transcription

Indexed keywords

CYTIDINE DEAMINASE; IMMUNOGLOBULIN LAMBDA CHAIN; INTERFERON REGULATORY FACTOR 4; TRANSCRIPTION FACTOR PU 1;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BINDING SITE; CHICKEN; CONTROLLED STUDY; ENZYME REGULATION; GEL MOBILITY SHIFT ASSAY; GENE CONVERSION; GENE LOCUS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; AVIAN PROTEINS; B-LYMPHOCYTES; BINDING SITES; CELL LINE; CHICKENS; CYTIDINE DEAMINASE; DNA METHYLATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOGLOBULIN LAMBDA-CHAINS; INTERFERON REGULATORY FACTORS; MUTATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS;

EID: 77950628395     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.02.016     Document Type: Article

References (54)

1. Arakawa H., Lodygin D., Buerstedde J.M. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol. 2001, 1:7.
2. Arakawa H., Hauschild J., Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 2002, 295:1301-1306.
3. Arakawa H., Buerstedde J.M. Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line. Dev. Dyn. 2004, 229:458-464.
4. Arakawa H., Saribasak H., Buerstedde J.M. Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol. 2004, 2:967-974.
5. Blagodatski A., Batrak V., Schmidl S., Schoetz U., Caldwell R.B., Arakawa H., Buerstedde J.M. A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation. PLoS Genet. 2009, 5:e1000332.
6. Buerstedde J.M., Reynaud C.A., Humphries E.H., Olson W., Ewert D.L., Weill J.C. Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J. 1990, 9:921-927.
7. Conlon T.M., Meyer K.B. The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. Eur. J. Immunol. 2006, 36:139-148.
8. Dedeoglu F., Horwitz B., Chaudhuri J., Alt F.W., Geha R.S. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int. Immunol. 2004, 16:395-404.
9. Di Noia J.M., Neuberger M.S. Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur. J. Immunol. 2004, 34:504-508.
10. Di Noia J.M., Neuberger M.S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 2007, 76:1-22.
11. Di Noia J.M., Williams G.T., Chan D.T., Buerstedde J.M., Baldwin G.S., Neuberger M.S. Dependence of antibody gene diversification on uracil excision. J. Exp. Med. 2007, 204:3209-3219.
12. Eisenbeis C.F., Singh H., Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995, 9:1377-1387.
13. Gonda H., Sugai M., Nambu Y., Katakai T., Agata Y., Mori K.J., Yokota Y., Shimizu A. The balance between Pax5 and Id2 activities is the key to AID gene expression. J. Exp. Med. 2003, 198:1427-1437.
14. Harris R.S., Sale J.E., Petersen-Mahrt S.K., Neuberger M.S. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr. Biol. 2002, 12:435-438.
15. Horton J.R., Liebert K., Bekes M., Jeltsch A., Cheng X. Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. J. Mol. Biol. 2006, 358:559-570.
16. Inlay M.A., Gao H.H., Odegard V.H., Lin T., Schatz D.G., Xu Y. Roles of the Ig kappa light chain intronic and 3′ enhancers in Igk somatic hypermutation. J. Immunol. 2006, 177:1146-1151.
17. Kanayama N., Todo K., Takahashi S., Magari M., Ohmori H. Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line. Nucleic Acids Res. 2006, 34:e10.
18. Kanno Y., Levi B.-Z., Tamura T., Ozato K. Immune cell-specific amplification of interferon signaling by the IRF4/8-PU.1 complex. J. Interferon Cytokine Res. 2005, 25:770-779.
19. Kim S., Humphries E.H., Tjoelker L., Carlson L., Thompson C.B. Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line. Mol. Cell. Biol. 1990, 10:3224-3231.
20. Kim Y., Tian M. NF-κB family of transcription factor facilitates gene conversion in chicken B cells. Mol. Immunol. 2009, 46:3283-3291.
21. Kitao H., Kimura M., Yamamoto K., Seo H., Namikoshi K., Agata Y., Ohta K., Takata M. Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion. Int. Immunol. 2008, 20:277-284.
22. Klein U., Casola S., Cattoretti G., Shen Q., Lia M., Mo T., Ludwig T., Rajewsky K., Dalla-Favera R. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 2006, 7:773-782.
23. Kothapalli N., Norton D.D., Fugmann S.D. Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J. Immunol. 2008, 180:2019-2023.
24. Lazorchak A.S., Schlissel M.S., Zhuang Y. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol. Cell. Biol. 2006, 26:810-821.
25. Lee C.H., Melchers M., Wang H., Torrey T.A., Slota R., Qi C.F., Kim J.Y., Lugar P., Kong H.J., Farrington L., van der Zouwen B., Zhou J.X., Lougaris V., Lipsky P.E., Grammer A.C., Morse H.C. Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. J. Exp. Med. 2006, 203:63-72.
26. Liu M., Duke J.L., Richter D.J., Vinuesa C.G., Goodnow C.C., Kleinstein S.H., Schatz D.G. Two levels of protection for the B cell genome during somatic hypermutation. Nature 2008, 451:841-845.
27. Manis J.P., van der Stoep N., Tian M., Ferrini R., Davidson L., Bottaro A., Alt F.W. Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers. J. Exp. Med. 1988, 188:1421-1431.
28. McKercher S.R., Torbett B.E., Anderson K.L., Henkel G.W., Vestal D.J., Baribault H., Klemsz M., Feeney A.J., Wu G.E., Paige C.J., Maki R.A. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996, 15:5647-5658.
29. Michael N., Shen H.M., Longerich S., Kim N., Longacre A., Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 2003, 19:235-242.
30. Mittrücker H.W., Matsuyama T., Grossman A., Kündig T.M., Potter J., Shahinian A., Wakeham A., Patterson B., Ohashi P.S., Mak T.W. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997, 275:540-543.
31. Morvan C.L., Pinaud E., Decourt C., Cuvillier A., Cogné M. The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation. Blood 2003, 102:1421-1427.
32. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
33. Nagulapalli S., Atchison M.L. Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains. Mol. Cell. Biol. 1998, 18:4639-4650.
34. Nera K.P., Kohonen P., Narvi E., Peippo A., Mustonen L., Terho P., Koskela K., Buerstedde J.M., Lassila O. Loss of Pax5 promotes plasma cell differentiation. Immunity 2006, 24:283-293.
35. Odegard V.H., Schatz D.G. Targeting of somatic hypermutation. Nat. Rev. Immunol. 2006, 6:573-583.
36. Orian A., Abed M., Kenyagin-Karsenti D., Boico O. DamID: a methylation-based chromatin profiling approach. Methods Mol. Biol. 2009, 567:155-169.
37. Park S.R., Zan H., Pal Z., Zhang J., Al-Qahtani A., Pone E.J., Xu Z., Mai T., Casali P. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat. Immunol. 2009, 10:540-550.
38. Perlot T., Alt F.W., Bassing C.H., Suh H., Pinaud E. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:14362-14367.
39. Pinaud E., Khamlichi A.A., Le Morvan C., Drouet M., Nalesso V., Le Bert M., Cogné M. Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination. Immunity 2001, 15:187-199.
40. Polli M., Dakic A., Light A., Wu L., Tarlinton D.M., Nutt S.L. The development of functional B lymphocytes in conditional PU.1 knock-out mice. Blood 2005, 106:2083-2090.
41. Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., Tezcan I., Ersoy F., Kayserili H., Ugazio A.G., Brousse N., Muramatsu M., Notarangelo L.D., Kinoshita K., Honjo T., Fischer A., Durandy A. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000, 102:565-575.
42. Ronai D., Iglesias-Ussel M.D., Fan M., Shulman M.J., Scharff M.D. Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:11829-11834.
43. Rouet P., Smih F., Jasin M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell. Biol. 1994, 14:8096-8106.
44. Sale J.E., Calandrini D.M., Takata M., Takeda S., Neuberger M.S. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 2001, 412:921-926.
45. Saribasak H., Saribasak N.N., Ipek F.M., Ellwart J.W., Arakawa H., Buerstedde J.M. Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations. J. Immunol. 2006, 176:365-371.
46. Shivarov V., Shinkura R., Doi T., Begum N.A., Nagaoka H., Okazaki I.M., Ito S., Nonaka T., Kinoshita K., Honjo T. Molecular mechanism for generation of antibody memory. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:569-575.
47. Schoetz U., Cervelli M., Wang Y.D., Fiedler P., Buerstedde J.M. E2A expression stimulates Ig hypermutation. J. Immunol. 2006, 177:395-400.
48. Sciammas R., Shaffer A.L., Schatz J.H., Zhao H., Staudt L.M., Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006, 25:225-236.
49. Scott E.W., Simon M.C., Anastasi J., Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994, 265:1573-1577.
50. van der Stoep N., Gorman J.R., Alt F.W. Reevaluation of 3′Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity 1998, 8:743-750.
51. van der Stoep N., Quinten E., Rezende M., van den Elsen P. E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII). Blood 2004, 104:2849-2857.
52. van Steensel B., Henikoff S. Identification of in vivo DNA targets of chromatinproteins using tethered dam methyltransferase. Nat. Biotechnol. 2000, 18:424-428.
53. Xiang Y., Garrard W.T. The downstream transcriptional enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J. Immunol. 2008, 180:6725-6732.
54. Yang S.Y., Fugmann S.D., Schatz D.G. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J. Exp. Med. 2006, 203:2919-2928.