Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet

European Journal of Clinical Nutrition

Volumn 64, Issue 4, 2010, Pages 432-435

  Krogholm, K S ^a   Bredsdorff, L ^a   Knuthsen, P ^a   Haraldsdottir J ^b   Rasmussen, S E ^c  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Bioavailability; Biokinetics; Hesperetin; Humans; Naringenin; Quercetin

Indexed keywords

HESPERETIN; NARINGENIN; QUERCETIN; FLAVANONE DERIVATIVE; HESPERIDIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; URINALYSIS; BIOAVAILABILITY; BLOOD; CLINICAL TRIAL; DIET; URINE; YOUNG ADULT;

ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DIET; FLAVANONES; HESPERIDIN; HUMANS; MALE; QUERCETIN; YOUNG ADULT;

EID: 77950628201     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.6     Document Type: Article

References (10)

1. Arts ICW, Sesink ALA, Faassen-Peters M, Hollman PC (2004). The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr 91, 841-847. (Pubitemid 38931447)
2. Breinholt VM, Nielsen SE, Knuthsen P, Lauridsen ST, Daneshvar B, Sorensen A (2003). Effects of commonly consumed fruit juices and carbohydrates on redox status and anticancer biomarkers in female rats. Nutr Cancer 45, 46-52. (Pubitemid 36736891)
3. Erlund I, Meririnne E, Alfthan G, Aro A (2001). Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 131, 235-241. (Pubitemid 32115362)
4. Hollman PC, van Trijp JM, Buysman MN, van der Gaag MS, Mengelers MJ, de Vries JH et al. (1997). Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 418, 152-156. (Pubitemid 27514436)
5. Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C (2003). Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr 57, 235-242. (Pubitemid 36240474)
6. Manach C, Williamson G, Morand C, Scalbert A, Remesy C (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S-242S.
7. Matsukawa N, Matsumoto M, Hara H (2009). High biliary excretion levels of quercetin metabolites after administration of a quercetin glycoside in conscious bile duct cannulated rats. Biosci Biotech Biochem 73, 1863-1865.
8. Mullen W, Edwards CA, Crozier A (2006). Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 96, 107-116. (Pubitemid 44160903)
9. Mullen W, Rouanet JM, Auger C, Teissèdre P-L, Caldwell ST, Hartley RC et al. (2008). Bioavailability of [2-(14)C]quercetin- 40-glucoside in rats. J Agric Food Chem 56, 12127-12137.
10. Nielsen IL, Chee WS, Poulsen L, Offord-Cavin E, Rasmussen SE, Frederiksen H et al. (2006). Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr 136, 404-408. (Pubitemid 43228293)