Protein phosphatase 1α associates with protein tyrosine phosphatase-PEST inducing dephosphorylation of phospho-serine 39

Journal of Biochemistry

Volumn 147, Issue 4, 2010, Pages 493-500

  Nakamura, Kana ^a   Palmer, Helen E F ^a   Ozawa, Tomoko ^a,b   Mashima, Keisuke ^a  

^a RIKKYO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Dephosphorylation; PP1 ; PTP activity; PTP PEST; Yeast two hybrid system

Indexed keywords

PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOSERINE; PROTEIN PHOSPHATASE 1 ALPHA; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; HYBRID PROTEIN; MUTANT PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 12; PHOSPHOSPECIFIC ANTIBODY;

ANTIBODY SPECIFICITY; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; PLASMID; WILD TYPE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN DOMAIN; TWO HYBRID SYSTEM; WESTERN BLOTTING;

ANTIBODIES, PHOSPHO-SPECIFIC; BLOTTING, WESTERN; CATALYTIC DOMAIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; MUTANT PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PHOSPHATASE 1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12; RECOMBINANT FUSION PROTEINS; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77950616909     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp191     Document Type: Article

References (28)

1. Davidson, D. and Veillette, A. (2001) PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. EMBO J. 20, 3414-3426
2. Angers-Loustau, A., Cote, J.F., Charest, A., Dowbenko, D., Spencer, S., Lasky, L.A., and Tremblay, M.L. (1999) Protein tyrosine phosphatase- PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell. Biol. 144, 1019-1031
3. Brown, M.C. and Turner, C.E. (2002) Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int. J. Biochem. Cell. Biol. 34, 855-863
4. Sastry, S.K., Lyons, P.D., Schaller, M.D., and Burridge, K. (2002) PTP-PEST controls motility through regulation of Rac1. J. Cell. Sci. 115, 4305-4316
5. Garton, A.J. and Tonks, N.K. (1999) Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. J. Biol. Chem. 274, 3811-3818
6. Garton, A.J., Burnham, M.R., Bouton, A.H., and Tonks, N.K. (1997) Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene 15, 877-885
7. Garton, A.J., Flint, A.J., and Tonks, N.K. (1996) Identification of p130cas as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol. Cell. Biol. 16, 6408-6418
8. Lyons, P.D., Dunty, J.M., Schaefer, E.M., and Schaller, M.D. (2001) Inhibition of the catalytic activity of cell adhesion kinase b by protein-tyrosine phosphatase-PEST-mediated dephosphorylation. J. Biol. Chem. 276, 24422-24431
9. Shen, Y., Lyons, P., Cooley, M., Davidson, D., Veillette, A., Salgia, R., Griffin, J.D., and Schaller, M.D. (2000) The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo. J. Biol. Chem. 275, 1405-1413
10. Sastry, S.K., Rajfur, Z., Liu, B.P., Cote, J.F., Tremblay, M.L., and Burridge, K. (2006) PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J. Biol. Chem. 281, 11627-11636
11. Cong, F., Spencer, S., Cote, J.F., Wu, Y., Tremblay, M.L., Lasky, L.A., and Goff, S.P. (2000) Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation. Mol. Cell. 6, 1413-1423
12. Cote, J.F., Chung, P.L., Theberge, J.F., Halle, M., Spencer, S., Lasky, L.A., and Tremblay, M.L. (2002) PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J. Biol. Chem. 277, 2973-2986
13. Chellaiah, M.A., Kuppuswamy, D., Lasky, L., and Linder, S. (2007) Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption. J. Biol. Chem. 282, 10104-10116
14. Badour, K., Zhang, J., Shi, F., Leng, Y., Collins, M., and Siminovitch, K.A. (2004) Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J. Exp. Med. 199, 99-112
15. Arimura, Y., Vang, T., Tautz, L., Williams, S., and Mustelin, T. (2008) TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Mol. Immunol. 45, 3074-3084
16. Garton, A.J. and Tonks, N.K. (1994) PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. EMBO J. 13, 3763-3771
17. Zhang, J., Zhang, Z., Brew, K., and Lee, E.Y. (1996) Mutational analysis of the catalytic subunit of muscle protein phosphatase-1. Biochemistry 35, 6276-6282
18. Gupta, A., Lee, B.S., Khadeer, M.A., Tang, Z., Chellaiah, M., Abu-Amer, Y., Goldknopf, J., and Hruska, K.A. (2003) Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J. Bone Miner. Res. 18, 669-685
19. Nishiya, N., Iwabuchi, Y., Shibanuma, M., Cote, J.F., Tremblay, M.L., and Nose, K. (1999) Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain. J. Biol. Chem. 274, 9847-9853
20. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39
21. Cohen, P.T. (2002) Protein phosphatase 1-targeted in many directions. J. Cell. Sci. 115, 241-256
22. Garcia, A., Cayla, X., Caudron, B., Deveaud, E., Roncal, F., and Rebollo, A. (2004) New insights in protein phosphorylation: a signature for protein phosphatase 1 interacting proteins. C. R. Biol. 327, 93-97
23. Sirois, J., Cote, J.F., Charest, A., Uetani, N., Bourdeau, A., Duncan, S.A., Daniels, E., and Tremblay, M.L. (2006) Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech. Dev. 123, 869-880
24. Sahu, S.N., Nunez, S., Bai, G., and Gupta, A. (2007) Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. Am. J. Physiol. Cell. Physiol. 292, C2288-C2296
25. Wade, R., Bohl, J., and Vande Pol, S. (2002) Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene 21, 96-107
26. Cote, J.F., Charest, A., Wagner, J., and Tremblay, M.L. (1998) Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model. Biochemistry 37, 13128-13137
27. Yang, H. and Reinherz, E.L. (2006) CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. J. Immunol. 176, 5898-5907
28. Lu, T.J., Lai, W.Y., Huang, C.Y., Hsieh, W.J., Yu, J.S., Hsieh, Y.J., Chang, W.T., Leu, T.H., Chang, W.C., Chuang, W.J., Tang, M.J., Chen, T.Y., Lu, T.L., and Lai, M.D. (2006) Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J. Biol. Chem. 281, 38405-38417