Antagonizing microRNA-122 and treatment of hepatitis C virus infection

Hepatology

Volumn 51, Issue 4, 2010, Pages 1461-1463

  Pfeffer, Sébastien ^a   Baumert, Thomas F ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b HÔPITAL CIVIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; MICRORNA; PEGINTERFERON ALPHA; RIBAVIRIN; SPC 3649; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANTIVIRAL THERAPY; CHIMPANZEE; DOWN REGULATION; DRUG EFFICACY; DRUG SAFETY; GENE TARGETING; HEPATITIS C; HISTOLOGY; HUMAN; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TOXICITY; NONHUMAN; NOTE; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; VIREMIA;

EID: 77950606643     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23573     Document Type: Note

References (12)

1. Tai AW, Chung RT. Treatment failure in hepatitis C: mechanisms of non-response. J Hepatol 2009;50:412-420.
2. Hezode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009;360:1839-1850.
3. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
4. Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 2007;17:118-126.
5. Gottwein E, Cullen BR. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 2008;3:375-387.
6. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005;309:1577-1581.
7. Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med 2009;15:31-33.
8. Meister G, Landthaler M, Dorsett Y, Tuschl T. Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing. RNA 2004; 10:544-550.
9. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438:685-689.
10. Elmen J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thom-sen A, et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008;36:1153-1162.
11. Elmen J, Lindow M, Schutz S, Lawrence M, Petri A, Obad S, et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008;452:896-899.
12. Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010;327:198-201.