-
1
-
-
33645653691
-
Are development times for pharmaceuticals increasing or decreasing?
-
J
-
Keyhani S, Diener-West M, Powe N. Are development times for pharmaceuticals increasing or decreasing? [J]. Health Aff (Millwood), 2006, 25, 461-468.
-
(2006)
Health Aff (Millwood)
, vol.25
, pp. 461-468
-
-
Keyhani, S.1
Diener-West, M.2
Powe, N.3
-
2
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
J
-
Hopkins AL. Network pharmacology: the next paradigm in drug discovery [J]. Nat Chem Biol, 2008, 11: 682-690.
-
(2008)
Nat Chem Biol
, vol.11
, pp. 682-690
-
-
Hopkins, A.L.1
-
3
-
-
27144443099
-
Drug discovery: Playing dirty
-
J
-
Frantz S. Drug discovery: playing dirty [J]. Nature, 2005, 437: 942-943.
-
(2005)
Nature
, vol.437
, pp. 942-943
-
-
Frantz, S.1
-
4
-
-
33847377573
-
A robustness-based approach to systems-oriented drug design
-
DOI 10.1038/nrd2195, PII NRD2195
-
Kitano H. A robustness-based approach to systems-oriented drug design [J]. Nat Rev Drug Discov, 2007: 202-210. (Pubitemid 46344624)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.3
, pp. 202-210
-
-
Kitano, H.1
-
5
-
-
34547140875
-
The human disease network
-
J
-
Goh KI, Cusick ME, Valle D, et al. The human disease network [J]. Proc Natl Acad Sci USA, 2007, 104: 8685-8690.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
-
6
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
J
-
Daniel MR, Søren GFR, Brian KK. The structure and function of G-protein-coupled receptors [J]. Nature, 2009, 459: 356-363.
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Daniel, M.R.1
Søren, G.F.R.2
Brian, K.K.3
-
7
-
-
34250743173
-
Systematic Discovery of in Vivo Phosphorylation Networks
-
DOI 10.1016/j.cell.2007.05.052, PII S0092867407007271
-
Linding R, Jensen LJ, Ostheimer GT, et al. Systematic discovery of in vivo phosphorylation networks [J]. Cell, 2007, 129: 1415-1426. (Pubitemid 46962092)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1415-1426
-
-
Linding, R.1
Jensen, L.J.2
Ostheimer, G.J.3
Van Vugt, M.A.T.M.4
Jorgensen, C.5
Miron, I.M.6
Diella, F.7
Colwill, K.8
Taylor, L.9
Elder, K.10
Metalnikov, P.11
Nguyen, V.12
Pasculescu, A.13
Jin, J.14
Park, J.G.15
Samson, L.D.16
Woodgett, J.R.17
Russell, R.18
Bork, P.19
Yaffe, M.B.20
Pawson, T.21
more..
-
8
-
-
33846554088
-
Modeling HER2 effects on cell behavior from mass-spectrometry phosphotyrosine data
-
J
-
Kumar N, Wolf-Yadlin A, White FM, et al. Modeling HER2 effects on cell behavior from mass-spectrometry phosphotyrosine data [J]. PLoS Comput Biol, 2007, 3: e4.
-
(2007)
PLoS Comput Biol
, vol.3
-
-
Kumar, N.1
Wolf-Yadlin, A.2
White, F.M.3
-
9
-
-
50849139572
-
Proteinases as hormones: Targets and mechanisms for proteolytic signaling
-
J
-
Hansen KK, Oikonomopoulou K, Baruch A, et al. Proteinases as hormones: targets and mechanisms for proteolytic signaling [J]. Biol Chem, 2008, 389: 971-982.
-
(2008)
Biol Chem
, vol.389
, pp. 971-982
-
-
Hansen, K.K.1
Oikonomopoulou, K.2
Baruch, A.3
-
10
-
-
33750456519
-
Global, in Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
-
DOI 10.1016/j.cell.2006.09.026, PII S0092867406012748
-
Olsen JV, Blagoev B, Gnad F, et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks [J]. Cell, 2006, 127: 635-648. (Pubitemid 44647421)
-
(2006)
Cell
, vol.127
, Issue.3
, pp. 635-648
-
-
Olsen, J.V.1
Blagoev, B.2
Gnad, F.3
Macek, B.4
Kumar, C.5
Mortensen, P.6
Mann, M.7
-
11
-
-
41149167511
-
Network medicine
-
J
-
Pawsona T, Linding R. Network medicine [J]. FEBS Lett, 2008, 582: 1266-1270.
-
(2008)
FEBS Lett
, vol.582
, pp. 1266-1270
-
-
Pawsona, T.1
Linding, R.2
-
12
-
-
55749111058
-
Linear motif atlas for phosphorylation-dependent signaling
-
J
-
Miller ML, Jensen LJ, Diella F, et al. Linear motif atlas for phosphorylation-dependent signaling [J]. Sci Signal, 2008, 1: 2.
-
(2008)
Sci Signal
, vol.1
, pp. 2
-
-
Miller, M.L.1
Jensen, L.J.2
Diella, F.3
-
13
-
-
58149159905
-
Network modeling of signal transduction: Establishing the global view
-
J
-
Kestler HA, Wawra C, Kracher B, et al. Network modeling of signal transduction: establishing the global view [J]. Bioessays, 2008, 30: 1110-1125.
-
(2008)
Bioessays
, vol.30
, pp. 1110-1125
-
-
Kestler, H.A.1
Wawra, C.2
Kracher, B.3
-
14
-
-
67249163020
-
Controlling aracbidonic acid metabolic network: From single- To multi-target inhibitors of key enzymes
-
J
-
Liu Y, Chen Z, Shang EC, et al. Controlling aracbidonic acid metabolic network: from single- to multi-target inhibitors of key enzymes [J]. Acta Pharm Sin, 2009, 44: 231-241.
-
(2009)
Acta Pharm Sin
, vol.44
, pp. 231-241
-
-
Liu, Y.1
Chen, Z.2
Shang, E.C.3
-
15
-
-
67249120693
-
The signal transduction pathway of multi-target kinase inhibitors as anticancer agents in clinical use or in phase III
-
J
-
Wu W, Lu C, Chen SY, et al. The signal transduction pathway of multi-target kinase inhibitors as anticancer agents in clinical use or in phase III [J]. Acta Pharm Sin, 2009, 44: 242-257.
-
(2009)
Acta Pharm Sin
, vol.44
, pp. 242-257
-
-
Wu, W.1
Lu, C.2
Chen, S.Y.3
-
16
-
-
34250722602
-
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
-
DOI 10.1073/pnas.0608638104
-
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, et al. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks [J]. Proc Natl Acad Sci USA, 2007, 104: 5860-5865. (Pubitemid 47175624)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.14
, pp. 5860-5865
-
-
Wolf-Yadlin, A.1
Hautaniemi, S.2
Lauffenburger, D.A.3
White, F.M.4
-
17
-
-
44649115241
-
Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
-
J
-
Chittenden TW, Howe EA, Culhane AC, et al. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers [J]. Genomics, 2008, 91: 508-511.
-
(2008)
Genomics
, vol.91
, pp. 508-511
-
-
Chittenden, T.W.1
Howe, E.A.2
Culhane, A.C.3
-
18
-
-
35348891430
-
Network-based classification of breast cancer metastasis
-
DOI 10.1038/msb4100180, PII MSB4100180
-
Chuang HY, Lee E, Liu YT, et al. Network-based classification of breast cancer metastasis [J]. Mol Syst Biol, 2007, 140. (Pubitemid 47587026)
-
(2007)
Molecular Systems Biology
, vol.3
, pp. 140
-
-
Chuang, H.-Y.1
Lee, E.2
Liu, Y.-T.3
Lee, D.4
Ideker, T.5
-
19
-
-
34547623194
-
Common effector processing mediates cell-specific responses to stimuli
-
DOI 10.1038/nature06001, PII NATURE06001
-
Miller-Jensen K, Janes KA, Brugge JS, et al. Common effector processing mediates cell-specific responses to stimuli [J]. Nature, 2007, 448: 604-608. (Pubitemid 47206933)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 604-608
-
-
Miller-Jensen, K.1
Janes, K.A.2
Brugge, J.S.3
Lauffenburger, D.A.4
-
20
-
-
47349124275
-
What does systems biology mean for drug development?
-
J
-
Schrattenholz A, Soskić V. What does systems biology mean for drug development? [J]. Curr Med Chem, 2008, 15: 1520-1528.
-
(2008)
Curr Med Chem
, vol.15
, pp. 1520-1528
-
-
Schrattenholz, A.1
Soskić, V.2
-
21
-
-
35349024501
-
Network modeling links breast cancer susceptibility and centrosome dysfunction
-
DOI 10.1038/ng.2007.2, PII NG20072
-
Pujana MA, Han JD, Starita LM, et al. Network modeling links breast cancer susceptibility and centrosome dysfunction [J]. Nat Genet, 2007, 39: 1338-1349. (Pubitemid 350035000)
-
(2007)
Nature Genetics
, vol.39
, Issue.11
, pp. 1338-1349
-
-
Pujana, M.A.1
Han, J.-D.J.2
Starita, L.M.3
Stevens, K.N.4
Tewari, M.5
Ahn, J.S.6
Rennert, G.7
Moreno, V.8
Kirchhoff, T.9
Gold, B.10
Assmann, V.11
Elshamy, W.M.12
Rual, J.-F.13
Levine, D.14
Rozek, L.S.15
Gelman, R.S.16
Gunsalus, K.C.17
Greenberg, R.A.18
Sobhian, B.19
Bertin, N.20
Venkatesan, K.21
Ayivi-Guedehoussou, N.22
Sole, X.23
Hernandez, P.24
Lazaro, C.25
Nathanson, K.L.26
Weber, B.L.27
Cusick, M.E.28
Hill, D.E.29
Offit, K.30
Livingston, D.M.31
Gruber, S.B.32
Parvin, J.D.33
Vidal, M.34
more..
|