메뉴 건너뛰기




Volumn 45, Issue 1, 2010, Pages 1-8

Drug targets discovery based on dynamic signal transduction networks

Author keywords

Cellular signal transduction network; Drug target; System modeling; Systems biology

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; BCR ABL PROTEIN; DASATINIB; ERLOTINIB; G PROTEIN COUPLED RECEPTOR; IMATINIB; JANUS KINASE; LAPATINIB; MIDOSTAURIN; NILOTINIB; PAZOPANIB; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RAF PROTEIN; SORAFENIB; SUNITINIB; VANDETANIB;

EID: 77950602744     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (7)

References (22)
  • 1
    • 33645653691 scopus 로고    scopus 로고
    • Are development times for pharmaceuticals increasing or decreasing?
    • J
    • Keyhani S, Diener-West M, Powe N. Are development times for pharmaceuticals increasing or decreasing? [J]. Health Aff (Millwood), 2006, 25, 461-468.
    • (2006) Health Aff (Millwood) , vol.25 , pp. 461-468
    • Keyhani, S.1    Diener-West, M.2    Powe, N.3
  • 2
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • J
    • Hopkins AL. Network pharmacology: the next paradigm in drug discovery [J]. Nat Chem Biol, 2008, 11: 682-690.
    • (2008) Nat Chem Biol , vol.11 , pp. 682-690
    • Hopkins, A.L.1
  • 3
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • J
    • Frantz S. Drug discovery: playing dirty [J]. Nature, 2005, 437: 942-943.
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 4
    • 33847377573 scopus 로고    scopus 로고
    • A robustness-based approach to systems-oriented drug design
    • DOI 10.1038/nrd2195, PII NRD2195
    • Kitano H. A robustness-based approach to systems-oriented drug design [J]. Nat Rev Drug Discov, 2007: 202-210. (Pubitemid 46344624)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 202-210
    • Kitano, H.1
  • 6
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-protein-coupled receptors
    • J
    • Daniel MR, Søren GFR, Brian KK. The structure and function of G-protein-coupled receptors [J]. Nature, 2009, 459: 356-363.
    • (2009) Nature , vol.459 , pp. 356-363
    • Daniel, M.R.1    Søren, G.F.R.2    Brian, K.K.3
  • 8
    • 33846554088 scopus 로고    scopus 로고
    • Modeling HER2 effects on cell behavior from mass-spectrometry phosphotyrosine data
    • J
    • Kumar N, Wolf-Yadlin A, White FM, et al. Modeling HER2 effects on cell behavior from mass-spectrometry phosphotyrosine data [J]. PLoS Comput Biol, 2007, 3: e4.
    • (2007) PLoS Comput Biol , vol.3
    • Kumar, N.1    Wolf-Yadlin, A.2    White, F.M.3
  • 9
    • 50849139572 scopus 로고    scopus 로고
    • Proteinases as hormones: Targets and mechanisms for proteolytic signaling
    • J
    • Hansen KK, Oikonomopoulou K, Baruch A, et al. Proteinases as hormones: targets and mechanisms for proteolytic signaling [J]. Biol Chem, 2008, 389: 971-982.
    • (2008) Biol Chem , vol.389 , pp. 971-982
    • Hansen, K.K.1    Oikonomopoulou, K.2    Baruch, A.3
  • 10
    • 33750456519 scopus 로고    scopus 로고
    • Global, in Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
    • DOI 10.1016/j.cell.2006.09.026, PII S0092867406012748
    • Olsen JV, Blagoev B, Gnad F, et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks [J]. Cell, 2006, 127: 635-648. (Pubitemid 44647421)
    • (2006) Cell , vol.127 , Issue.3 , pp. 635-648
    • Olsen, J.V.1    Blagoev, B.2    Gnad, F.3    Macek, B.4    Kumar, C.5    Mortensen, P.6    Mann, M.7
  • 11
    • 41149167511 scopus 로고    scopus 로고
    • Network medicine
    • J
    • Pawsona T, Linding R. Network medicine [J]. FEBS Lett, 2008, 582: 1266-1270.
    • (2008) FEBS Lett , vol.582 , pp. 1266-1270
    • Pawsona, T.1    Linding, R.2
  • 12
    • 55749111058 scopus 로고    scopus 로고
    • Linear motif atlas for phosphorylation-dependent signaling
    • J
    • Miller ML, Jensen LJ, Diella F, et al. Linear motif atlas for phosphorylation-dependent signaling [J]. Sci Signal, 2008, 1: 2.
    • (2008) Sci Signal , vol.1 , pp. 2
    • Miller, M.L.1    Jensen, L.J.2    Diella, F.3
  • 13
    • 58149159905 scopus 로고    scopus 로고
    • Network modeling of signal transduction: Establishing the global view
    • J
    • Kestler HA, Wawra C, Kracher B, et al. Network modeling of signal transduction: establishing the global view [J]. Bioessays, 2008, 30: 1110-1125.
    • (2008) Bioessays , vol.30 , pp. 1110-1125
    • Kestler, H.A.1    Wawra, C.2    Kracher, B.3
  • 14
    • 67249163020 scopus 로고    scopus 로고
    • Controlling aracbidonic acid metabolic network: From single- To multi-target inhibitors of key enzymes
    • J
    • Liu Y, Chen Z, Shang EC, et al. Controlling aracbidonic acid metabolic network: from single- to multi-target inhibitors of key enzymes [J]. Acta Pharm Sin, 2009, 44: 231-241.
    • (2009) Acta Pharm Sin , vol.44 , pp. 231-241
    • Liu, Y.1    Chen, Z.2    Shang, E.C.3
  • 15
    • 67249120693 scopus 로고    scopus 로고
    • The signal transduction pathway of multi-target kinase inhibitors as anticancer agents in clinical use or in phase III
    • J
    • Wu W, Lu C, Chen SY, et al. The signal transduction pathway of multi-target kinase inhibitors as anticancer agents in clinical use or in phase III [J]. Acta Pharm Sin, 2009, 44: 242-257.
    • (2009) Acta Pharm Sin , vol.44 , pp. 242-257
    • Wu, W.1    Lu, C.2    Chen, S.Y.3
  • 17
    • 44649115241 scopus 로고    scopus 로고
    • Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
    • J
    • Chittenden TW, Howe EA, Culhane AC, et al. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers [J]. Genomics, 2008, 91: 508-511.
    • (2008) Genomics , vol.91 , pp. 508-511
    • Chittenden, T.W.1    Howe, E.A.2    Culhane, A.C.3
  • 19
    • 34547623194 scopus 로고    scopus 로고
    • Common effector processing mediates cell-specific responses to stimuli
    • DOI 10.1038/nature06001, PII NATURE06001
    • Miller-Jensen K, Janes KA, Brugge JS, et al. Common effector processing mediates cell-specific responses to stimuli [J]. Nature, 2007, 448: 604-608. (Pubitemid 47206933)
    • (2007) Nature , vol.448 , Issue.7153 , pp. 604-608
    • Miller-Jensen, K.1    Janes, K.A.2    Brugge, J.S.3    Lauffenburger, D.A.4
  • 20
    • 47349124275 scopus 로고    scopus 로고
    • What does systems biology mean for drug development?
    • J
    • Schrattenholz A, Soskić V. What does systems biology mean for drug development? [J]. Curr Med Chem, 2008, 15: 1520-1528.
    • (2008) Curr Med Chem , vol.15 , pp. 1520-1528
    • Schrattenholz, A.1    Soskić, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.