Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/h+

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 989-994

  Forster, H V ^a   Smith, C A ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Breathing; Carbon dioxide; Carotid chemoreceptors; Central chemoreceptors; Interaction

Indexed keywords

CARBON DIOXIDE; CARBON DIOXIDE RECEPTOR; CELL SURFACE RECEPTOR;

ANIMAL; CAROTID BODY; CENTRAL NERVOUS SYSTEM; DISEASE MODEL; GOAT; HUMAN; LUNG VENTILATION; METABOLISM; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; REVIEW;

ANIMALS; CARBON DIOXIDE; CAROTID BODY; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; GOATS; HUMANS; PERIPHERAL NERVOUS SYSTEM; PULMONARY VENTILATION; RECEPTORS, CELL SURFACE;

EID: 77950581249     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01059.2009     Document Type: Review

References (63)

1. Berger W, Berger K, Berndt J, Giese K. Interaction of peripheral and central respiratory drives in cats. I. Effects of sodium cyanide as a peripheral chemoreceptor stimulus at different levels of CSF pH. Pflügers Arch 374: 205-210, 1978. (Pubitemid 8359700)
2. Bisgard GE, Forster HV, Klein JP. Recovery of peripheral chemore- ceptor function after denervation in ponies. J Appl Physiol 49: 964-970, 1980.
3. Bisgard GE, Forster HV, Orr JA, Buss DD, Rawlings CA, Rasmussen B. Hypoventilation in ponies after carotid body denervation. J Appl Physiol 40: 184-190, 1976.
4. Blain GM, Smith CA, Henderson KS, Dempsey JA. Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanes- thetized dog. J Appl. Physiol 106: 1564-1573, 2009.
5. Busch MA, Bisgard GE, Forster HV. Ventilatory acclimatization to hypoxia is not dependent on arterial hypoxemia. J Appl Physiol 58: 1874-1880, 1985.
6. Busch MA, Bisgard GE, Mesina JE, Forster HV. The effects of unilateral carotid body excision on ventilatory control in goats. Respir Physiol 54: 353-361, 1983. (Pubitemid 14177495)
7. 2 in the awake lamb: role of the carotid chemoreceptors. J Appl Physiol 71: 2198-2205, 1991.
8. Clement ID, Bascom DA, Robbins PA. An assessment of centralperipheral ventilatory chemoreflex interaction in humans. Respir Physiol 88: 87-100, 1992.
9. Clement ID, Pandit JJ, Bascom DA, Dorrington KL, O'Connor DF, Robbins PA. An assessment of central-peripheral ventilatory chemoreflex interaction using acid and bicarbonate infusions in humans. J Physiol 485: 561-570, 1995.
10. Daristotle L, Bisgard GE. Central-peripheral chemoreceptor ventilatory interaction in awake goats. Respir Physiol 76: 383-391, 1989. (Pubitemid 19160935)
11. 2 modulates phrenic responses to specific carotid body hypoxia in an in situ dual perfused rat preparation. J Physiol 578: 843-857, 2007.
12. Day TA, Wilson RJA. A negative interaction between brainstem and peripheral respiratory chemoreceptors modulates peripheral chemoreflex magnitude. J Physiol 587: 883-896, 2009.
13. Dean JB, Mulkey DK, Henderson TA, Potter SJ, Putnam RW. Hyperoxia, reactive oxygen species and hyperventilation: oxygen sensitivity of brainstem neurons. J Appl Physiol 96: 784-791, 2004. (Pubitemid 38140187)
14. Eldridge FL, Gill-Kumar P, Millhorn DE. Input-output relationships of central neural circuits involved in respiration in cats. J Physiol 311: 81-95, 1981. (Pubitemid 11166910)
15. Fencl V, Miller TB, Pappenheimer JR. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol, 210: 459-472, 1966.
16. Forster HV, Ohtake PJ, Pan LG, Lowry TF. Effect on breathing of surface ventrolateral medullary cooling in awake, anesthetized and asleep goats. Respir Physiol 110: 187-197, 1997.
17. Forster HV, Ohtake PJ, Pan LG, Lowry TF, Korducki MJ, Aaron EA, Forster AL. Effects on breathing of ventrolateral medullary cooling in awake goats. J Appl Physiol 78: 258-265, 1995.
18. 2 during eupneic breathing. Adv Exp Med Biol 905: 322-326, 2007.
19. Gesell R, Lapides J, Levin M. The interaction of central and peripheral chemical control of breathing. Am J Physiol 130: 155-170, 1940.
20. Giese K, Berndt J, Berger W. Interaction of central and peripheral respiratory drives in cats. II. Peripheral and central interaction of hypoxia and hypercapnia. Pflügers Arch 374: 211-217, 1978. (Pubitemid 8359701)
21. 2 homeostasis, and breathing automaticity. J Appl Physiol 105: 404-416, 2008.
22. Guyenet PG, Bayliss DA, Mulkey DK, Stornetta RL, Moreira TS, Takakura AT. The retrotrapezoid nucleus and central chemoreception. Adv Exp Med Biol 605: 327-332, 2008.
23. Guyenet PG, Stornetta RL, Bayliss DA. Retrotrapezoid nucleus and central chemoreception. J Physiol 586: 2043-2048, 2008.
24. Guyenet PG, Stornetta RL, Bayliss DA, Mulkey DK. Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors. Exp Physiol 90: 247-253, 2005. (Pubitemid 40685833)
25. Hayashi F, Sinclair JD. Respiratory patterns in anesthetised rats before and after anemic decerebration. Respir Physiol, 84: 61-76, 1991.
26. Heeringa J, Berkenbosch A, de Goede J, Olievier CN. Relative contribution of central and peripheral chemoreceptors to the ventilatory response to CO2 during hyperoxia. Respir Physiol 37: 365-379, 1979. (Pubitemid 9252971)
27. 2 sensi- tivity during hyperoxia. Respir Physiol 41: 333-347, 1980.
28. Hodges MR, Martino P, Davis S, Opansky C, Pan LG, Forster HV. Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats. J Appl Physiol 97: 2303-2309, 2004. (Pubitemid 39552471)
29. Hodges MR, Opansky C, Qian B, Davis S, Bonis JM, Krause K, Pan LG, Forster HV. Carotid body denervation alters ventilatory responses to ibotenic acid injections or focal acidosis in the medullary raphe. J Appl Physiol 98: 1234-1242, 2005. (Pubitemid 40396495)
30. Hoop B, Masjedi M, Shih VE, Kazemi H. Brain glutamate metabolism during hypoxia and peripheral chemodenervation. J Appl Physiol 69: 147-154, 1990. (Pubitemid 20230955)
31. Kinkead R, Zhan WZ, Prakash YS, Bach KB, Sieck GC, Mitchell GS. Cervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneuronsand serotonin-dependent long-term facilitation of respiratory motor output in rats. J Neurosci 18: 8436-8443, 1998. (Pubitemid 28465018)
32. Kiwull PH, Kiwull-Schone S, Klatt W. Interaction of central and peripheral respiratory drives: differentiation between the role of stimuli and afferents. In: Acid-Base Homeostasis of the Brain Extracellular Fluid and Respiratory Control System, edited by Loeschcke HH. Stuttgart, Germany: Thieme, 1976, p. 146-156.
33. Liu Q, Kim J, Cinotte J, Homolka P, Wong-Riley MT. Carotid body denervation effect on cytochrome oxidase activity in pre-Bötzinger com- plex of developing rats. J Appl Physiol 94: 1115-1121, 2003. (Pubitemid 36232028)
34. Loeschcke HH, Mitchell RA, Katsaros B, Perkins JF Jr, Konig A. Interaction of intracranial chemosensitivity with peripheral afferents to the respiratory centers. Ann NY Acad Sci 109: 651-660, 1963.
35. Millhorn DE, Eldridge FL, Waldrop TG. Effects of medullary area I cooling on respiratory response to muscle stimulation. Respir Physiol 49: 41-118, 1982.
36. Mitchell GS, Bach KB, Martin PA, Foley KT, Olson EB, Brownfleld MS, Miletic V, Behan M, McGuirk S, Sloan HE. Increased spinal monoamine concentrations after chronic thoracic dorsal rhizotomy in goats. J Appl Physiol 89: 1266-1274, 2000.
37. Moreira TS, Takakura AC, Colombari E, West GH, Guyenet PG. Inhibitory input from slowly adapting lung stretch receptors toretrotrap-ezoid nucleus chemoreceptors. J Physiol 580: 285-300, 2007. (Pubitemid 46470659)
38. Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA, Guyenet PG. Respiratory control by ventral surface chemo- receptor neurons in rats. Nat Neurosci 1: 1360-1369, 2004. (Pubitemid 41057759)
39. Musch Tl, Pelligrino A, Dempsey JA. Effects of prolonged N2O and barbiturate anesthesia on brain metabolism and pH in the dog. Respir Physiol 39: 121-131, 1980.
40. Nichols NL, Mulkey DK, Wilkinson KA, Powell FL, Dean JB, Putnam RW. Characterization of the chemosensitive response of individual soli-tary complex neurons from adult rats. Am J Physiol Regul Integr Comp Physiol 296: R763-R773, 2009.
41. Nuding SC, Segers LS, Shannon R, O'Connor R, Morris KF, Lindsey BG. Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network. Philos Trans R Soc Lond B Biol Sci 364: 2501-2516, 2009.
42. Ohtake PJ, Forster HV, Pan LG, Lowry TF, Korducki MJ, Aaron EA, Weiss EM. Ventilatory responses to cooling the ventrolateral medullary surface of awake and anesthetized goats. J Appl Physiol 78: 247-257, 1995.
43. Ohtake PJ, Forster HV, Pan LG, Lowry TF, Korducki MJ, Smith K, Forster AL. Effect on breathing of neuronal dysfunction in the caudal ventral medulla of goats. J Appl Physiol, 79: 1586-1594, 1995.
44. Pan LG, Forster HV, Ohtake PJ, Lowry TF, Korducki MJ, Forster AL. Effect of carotid chemoreceptor denervation on breathing during ventrolateral medullary cooling in goats. J Appl Physiol 79: 1120-1128, 1995.
45. Pan LG, Forster HV, Martinao P, Strecker PJ, Beales J, Serra A, Lowry TF, Forster MM, Forster AL. Important role of carotid afferents in control of breathing. J Appl Physiol 85: 1299-1306, 1998. (Pubitemid 28465056)
46. Pappenheimer JR. The ionic composition of cerebral extracellular fluid and its relation to control of breathing. Harvey Lect 6: 71-93, 1967.
47. Pappenheimer JR, Fencl V, Heisey SR, Held D. Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am J Physiol 208: 436-450, 1965.
48. 2 (pH) on the ventilatory response to hypoxic chemoreceptor stimulation.. Acta Physiol Pharmacol Neerl 12: 407-452, 1963.
49. Robbins PA. Evidence for interaction between the contributions to ven- tilation from the central and peripheral chemoreceptors in man. J Physiol 401: 503-518, 1988.
50. Rodman JR, Curran AK, Henderson KS, Dempsey JA, Smith CA. Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 91: 328-335, 2001.
51. Rosin DL, Chang DA, Guyenet PG. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 499: 64-89, 2006. (Pubitemid 44423696)
52. Schlaefke ME, Kille JF, Loeschcke HH. Elimination of central chemo- sensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats. Pflügers Arch 378: 231-241, 1979.
53. Schlaefke ME, Loeschcke HH. Lokalisation an der Regulation von Atmung und Kreislauf beteiligten Gebietes an der ventralen Oberfläche de Medulla oblongata durch Kälteblockade. Pflügers Arch 297: 201-220, 1967.
54. Schlaefke ME, See WR, Herker-See A, Loeschcke HH. Respiratory response to hypoxia and hypercapnia after elimination of central chemo-sensitivity. Pflügers Arch 381: 241-248, 1979. (Pubitemid 10194449)
55. Serra A, Brozoski D, Hedin N, Franciosi R, Forster HV. Mortality after carotid body denervation in rats. J Appl Physiol 91: 1298-1306, 2001. (Pubitemid 32803926)
56. Serra A, Brozoski D, Hodges M, Roethle S, Franciosi R, Forster HV. Effects of carotid and aortic chemoreceptor denervation in newborn piglets. J Appl Physiol. 92: 893-900, 2002. (Pubitemid 34670940)
57. Smith CA, Jameson LC, Mitchell GS, Musch TI, Dempsey JA. Cen- tral-peripheral chemoreceptor interaction in awake cerebrospinal fluid-perfused goats. J Appl Physiol 56: 1541-1549, 1984.
58. 2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors. J Appl Physiol 100: 13-19, 2006.
59. Smith CA, Saupe KW, Henderson KS, Dempsey JA. Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep. J Appl Physiol 79: 689-699, 1995.
60. Smith JC, Morrison DE, Ellenberger HH, Otto MR, Feldman JL. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 281: 69-96, 1989.
61. St Croix CM, Cunningham DA, Paterson DH. Nature of the interaction between central and peripheral chemoreceptor drives in human subjects. Can J Physiol Pharmacol 74: 640-646, 1996.
62. Stornetta RL, Moreira TS, Takakura AC, Kang BJ, Chang DA, West GH, Brunet JF, Mulkey DK, Bayliss DA, Guyenet PG. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. J Neurosci 26: 10305-10314, 2006.
63. 2-sensitive neurons in rats. J Physiol 572: 503-523, 2006.