The carotid chemoreceptors are a major determinant of ventilatory CO 2 sensitivity and of PaCO2 during eupneic breathing

Advances in Experimental Medicine and Biology

Volumn 605, Issue , 2008, Pages 322-326

  Forster, Hubert V ^a,c   Martino, Paul ^a   Hodges, Matt ^a   Krause, Katie ^a   Bonis, Josh ^a   Davis, Suzanne ^a   Pan, L ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MARQUETTE UNIVERSITY   (United States)

^c Zablocki VA Affairs Center

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; HYDROGEN;

AUTONOMIC DENERVATION; BREATHING PATTERN; CARBON DIOXIDE TENSION; CAROTID BODY CHEMORECEPTOR; CHEMOSENSITIVITY; CONFERENCE PAPER; HUMAN; HYPERCAPNIA; PRIORITY JOURNAL; RESPIRATORY ACIDOSIS; RESPIRATORY FUNCTION; ANIMAL; ANIMAL MODEL; ARTICLE; BRAIN; CAROTID BODY; CHEMORECEPTOR; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BRAIN; CARBON DIOXIDE; CAROTID BODY; CHEMORECEPTORS; HUMANS; HYPERCAPNIA; MODELS, ANIMAL; RESPIRATORY PHYSIOLOGY;

EID: 38449120825     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-73693-8_56     Document Type: Conference Paper

References (20)

1. Belleville, J.W., Whipp, B.J., Kaufman, R.D., Swanson, G.D., Aqleh, K.A. and Wiberg, D.M. (1979) Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46, 843-853.
2. Bisgard, G.E., Forster, H.V., Orr, J.A., Buss, D.D., Rawlings, C.A. and Rasmussen, B. (1976) Hypoventilation in ponies after carotid body denervation. J. Appl. Physiol. 40, 184-190.
3. Daristotle, L., Berssenbrugge, A.D., Engwall, M.J. and Bisgard, G.E. (1990) The effects of carotid body hypocapnia on ventilation in goats. Respir. Physiol. 79, 123-136.
4. Edelman, N.H., Epstein, P.E., Lahiri, S. and Cherniack, N.S. (1973) Ventilatory responses to transient hypoxia and hypercapnia in man. Respir. Physiol. 17, 302-314.
5. Fencl, V., Miller, T.B. and Pappenheimer, J.R. (1966) Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am. J. Physiol. 210, 459-472.
6. Forster, H.V., Pan, L.G., Lowry, T.F., Feroah, T., Gershan, W.M., Whaley, A.A. Forster, M.M. and Sprtel, B. (1998) Breathing of awake goats during prolonged dysfunction of caudal M ventro-lateral medullary neurons. J. Appl. Physiol. 84, 129-140.
7. Forster, H.V., Ohtake, P.J., Pan, L.G., Lowry, T.F., Korducki, M.J., Aaron, E.A. and Forster, A.L. (1995) Effects on breathing of ventrolateral medullary cooling in awake goats. J. Appl. Physiol. 78, 258-265.
8. Gray, P.A., Janczewski, W.A., Mellen, N., McCrimmon, D.R. and Feldman, J.L. (2001) Normal breathing requires pre-Bötzinger Complex neurokinin-1 receptor-expressing neurons. Nature Neurosci. 4, 927-930.
9. 2 during hyperoxia. Respir. Physiol. 37, 365-379.
10. 2 sensitivity after neurotoxic lesions in the medullary raphe area of awake goats. J. Appl. Physiol. 97, 2236-2247.
11. Hodges, M.R., Opansky, C., Qian, B., Davis, S., Bonis, J.M., Krause, K., Pan, L.G. and Forster, H.V. (2005) Carotid body denervation alters ventilatory responses to ibotenic acid injections or focal acidosis in the medullary raphe. J. Appl. Physiol. 98, 1234-1242.
12. 2 in normal and carotid body-denervated ponies. J. Appl. Physiol. 52, 1614-1622.
13. Lahiri, S. and DeLaney, R.G. (1975) Relationship between carotid chemoreceptor activity and ventilation in the cat. Respir. Physiol. 24, 267-286.
14. Martino, P.F., Davis, S., Opansky, C., Krause, K., Bonis, J., Pan, L.G., Qian, B., Forster, H.V. The cerebellar fastigial nucleus contributes to CO2-H+ ventilatory sensitivity in awake goats. J. Appl. Physiol., Resp. Physiol. and Neurobiol. in press.
15. Nattie, E. and Li, A. (2006) Neurokinin-1 receptor expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat. J. Appl. Physiol. 101: 1596-1606.
16. Pan, L.G., Forster, H.V., Martino, P., Strecker, P.J., Beales, J., Serra, A., Lowry, T.F., Forster, M.M. and Forster, A.L. (1998) Important role of carotid afferents in control of breathing. J. Appl. Physiol. 85, 1299-1306.
17. Pan, L.G., Forster, H.V., Ohtake, P.J., Lowry, T.F., Korducki, M.J. and Forster, A.L. (1995) Effect of carotid chemoreceptor denervation on breathing during ventrolateral medullary cooling in goats. J. Appl. Physiol. 79, 1120-1128.
18. Rodman, J.R., Curran, A.K., Henderson, K.S., Dempsey, J.A. and Smith, C.A. Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J. Appl. Physiol. 91, 328-335, 2001.
19. 2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors. J. Appl. Physiol. 100, 13-19.
20. 2-sensitive neurons in rats. J. Physiol. 572, 503-523.