Direct inhibition of the N-methyl-D-aspartate receptor channel by high concentrations of opioids

Anesthesiology

Volumn 91, Issue 4, 1999, Pages 1053-1063

  Yamakura, Tomohiro ^a   Sakimura, Kenji ^b   Shimoji, Koki ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b NONE

Author keywords

Channel blocker; Dissociative anesthetics; Glutamate receptor; Subunit

Indexed keywords

ASPARAGINE; CODEINE; FENTANYL; GLUTAMINE; KETAMINE; MAGNESIUM; MESSENGER RNA; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; OPIATE; PETHIDINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SPINAL CORD; XENOPUS;

AMINO ACID SEQUENCE; ANALGESICS, OPIOID; ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MAGNESIUM; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NARCOTIC ANTAGONISTS; OOCYTES; POINT MUTATION; RECEPTORS, N-METHYL-D-ASPARTATE; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 0032858252     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199910000-00026     Document Type: Article

References (45)

1. Faden AI, Jacobs TP, Holaday JW: Opiate antagonist improves neurologic recovery after spinal injury. Science 1981; 211:493-4
2. Kim JP, Goldberg MP, Choi DW: High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity. Eur J Pharmacol 1987; 138:133-6
3. Choi DW, Viseskul V: Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons. Eur J Pharmacol 1988; 155:27-35
4. Ebert B, Andersen S, Krogsgaard-Larsen P: Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord. Neurosci Lett 1995; 187:165-8
5. Andersen S, Dickenson AH, Kohn M, Reeve A, Rahman W, Ebert B: The opioid ketobemidone has a NMDA blocking effect. Pain 1996; 67:369-74
6. Gorman AL, Elliott KJ, Inturrisi CE: The d-and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neurosci Lett 1997; 223:5-8
7. Mori H, Mishina M: Structure and function of the NMDA receptor channel. Neuropharmacology 1995; 34:1219-37
8. Watanabe M, Mishina M, Inoue Y: Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord. J Comp Neurol 1994; 345:314-9
9. Tölle TR, Berthele A, Zieglgansberger W, Seeburg PH, Wisden W: The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci 1993; 13:5009-28
10. Burnashev N, Schoepfer R, Monyer H, Ruppersberg JP, Günther W, Seeburg PH, Sakmann B: Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 1992; 257:1415-9
11. 2+-block site of the NMDA receptor channel. Nature 1992; 358:673-5
12. Hume RI, Dingledine R, Heinemann SF: Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 1991; 253:1028-31
13. Yamakura T, Mori H, Masaki H, Shimoji K, Mishina M: Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists. NeuroReport 1993; 4:687-90
14. Yamakura T, Mori H, Shimoji K, Mishina M. Phosphorylation of the carboxyl-terminal domain of the ζ1 subunit is not responsible for potentiation by TPA of the NMDA receptor channel. Biochem Biophys Res Commun 1993; 196:1537-44
15. Mori H, Yamakura T, Masaki H, Mishina M: Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel. NeuroReport 1993; 4:519-22
16. Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, Inoue Y, Mishina M: Cloning and expression of the ∈4 subunit of the NMDA receptor channel. FEBS Lett 1992; 313:34-8
17. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, Mishina M: Molecular diversity of the NMDA receptor channel. Nature 1992; 358:36-41
18. Yamazaki M, Mori H, Araki K, Mori KJ, Mishina M: Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett 1992; 300:39-45
19. Sakimura K, Bujo H, Kushiya E, Araki K, Yamazaki M, Yamazaki M, Meguro H, Warashina A, Numa S, Mishina M: Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett 1990; 272:73-80
20. Leonard JP, Kelso SR: Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 1990; 4:53-60
21. Woodhull AM: Ionic blockage of sodium channels in nerve. J Gen Physiol 1973; 61:687-708
22. 2+ of NMDA responses in spinal cord neurones. Nature 1984; 309:261-3
23. Honey CR, Miljkovic Z, MacDonald JF: Ketamine and phencyclidine cause a voltage-dependent block of responses to L-aspartic acid. Neurosci Lett 1985; 61:135-9
24. Anis NA, Berry SC, Burton NR, Lodge D: Cyclazocine, like ketamine, blocks N-methylaspartate actions on spinal neurones in cat and rat. J Physiol 1983; 338:37-8P
25. Berry SC, Dawkins SL, Lodge D: Comparison of σ-and κ-opiate receptor ligands as excitatory amino acid antagonists. Br J Pharmacol 1984; 83:179-85
26. Church J, Lodge D, Berry SC: Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids. Eur J Pharmacol 1985; 111:185-90
27. Wong BY, Coulter DA, Choi DW, Prince DA: Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices. Neurosci Lett 1988; 85: 261-6
28. Yamamoto T, Yaksh TL: Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy. Neurosci Lett 1992; 135:67-70
29. Chapman V, Dickenson AH: The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 1992; 573:321-3
30. Trujillo KA, Akil H: Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 1991; 251: 85-7
31. Elliot K, Minami N, Kolesnikov YA, Pasternak GW, Inturrisi CE: The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor. NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 1994; 56:69-75
32. Austin KL, Stapleton JV, Mather LE: Relationship between blood meperidine concentrations and analgesic response: A preliminary report. ANESTHESIOLOGY 1980; 53:460-6
33. Neumann PB, Henriksen H, Grosman N, Christensen CB: Plasma morphine concentrations during chronic oral administration in patients with cancer pain. Pain 1982; 13:247-52
34. Thomson IR, Bergstrom RG, Rosenbloom M, Meatherall RC: Premedication and high-dose fentanyl anesthesia for myocardial revascularization: A comparison of lorazepam versus morphine-scopolamine. ANESTHESIOLOGY 1988; 68:194-200
35. Koren G, Goresky G, Crean P, Klein J, MacLeod SM: Pediatric fentanyl dosing based on pharmacokinetics during cardiac surgery. Anesth Analg 1984; 63:577-82
36. Glynn CJ, Mather LE, Cousins MJ, Graham JR, Wilson PR: Peridural meperidine in humans: Analgesic response, pharmacokinetics, and transmission into CSF. ANESTHESIOLOGY 1981; 55:520-6
37. Nordberg G, Hansdottir V, Bondesson U, Boreus LO, Mellstrand T, Hedner T: CSF and plasma pharmacokinetics of pethidine and norpethidine in man after epidural and intrathecal administration of pethidine. Eur J Clin Pharmacol 1988; 34:625-31
38. Ionescu TI, Drost RH, Roelofs JM, Winckers EK, Taverne RH, van Maris AA, van Rossum JM: The pharmacokinetics of intradural morphine in major abdominal surgery. Clin Pharmacokinet 1988; 14:178-86
39. Gustafsson LL, Grell AM, Garle M, Rane A, Schildt B: Kinetics of morphine in cerebrospinal fluid after epidural administration. Acta Anaesthesiol Scand 1984; 28:535-9
40. Gourlay GK, Murphy TM, Plummer JL, Kowalski SR, Cherry DA, Cousins MJ: Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous administration. Pain 1989; 38:253-9
41. Shimoyama N, Shimoyama M, Elliott KJ, Inturrisi CE: d-Methadone is antinociceptive in the rat formalin test. J Pharmacol Exp Ther 1997; 283:648-52
42. Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R: Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel. J Med Chem 1990; 33: 1296-305
43. Kroemer RT, Koutsilieri E, Hecht P, Liedl KR, Riederer P, Kornhuber J: Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site. J Med Chem 1998; 41:393-400
44. Thorpe DH: Opiate structure and activity-A guide to understanding the receptor. Anesth Analg 1984; 63:143-51
45. Parsons CG, Quack G, Bresink I, Baran L, Przegalinski E, Kostowski W, Krzascik P, Hartmann S, Danysz W: Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology 1995; 34:1239-58