Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling

Arthritis and Rheumatism

Volumn 62, Issue 4, 2010, Pages 952-959

  Sawamukai, Norifumi ^a,b   Yukawa, Sonosuke ^a   Saito, Kazuyoshi ^a   Nakayamada, Shingo ^a   Kambayashi, Taku ^b   Tanaka, Yoshiya ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FAS LIGAND; PROTEINASE ACTIVATED RECEPTOR 2; RHO KINASE; RHO KINASE INHIBITOR; STEM CELL FACTOR; TRYPTASE;

ADULT; APOPTOSIS; ARTICLE; ASSAY; CELL PROLIFERATION; CELL SURFACE; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; JOINT PROSTHESIS; JOINT SURGERY; MALE; MAST CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM;

APOPTOSIS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MAST CELLS; MIDDLE AGED; RECEPTOR, PAR-2; RHO FACTOR; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRYPTASES;

EID: 77950541887     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27331     Document Type: Article

References (27)

1. Gabriel SE. Why do people with rheumatoid arthritis still die prematurely? Ann Rheum Dis 2008;67 Suppl 3:iii30-4.
2. Nakayamada S, Saito K, Fujii K, Yasuda M, Tamura M, Tanaka Y. β1 integrin-mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas-mediated apoptosis. Arthritis Rheum 2003;48:1239-1248 (Pubitemid 36554523)
3. Fujii K, Fujii Y, Hubscher S, Tanaka Y. CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells. J Immunol 2001;167:1198-1203 (Pubitemid 32703113)
4. Sawamukai N, Saito K, Yamaoka K, Nakayamada S, Ra C, Tanaka Y. Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. J Immunol 2007;179:6479-6484
5. Nigrovic PA, Lee DM. Synovial mast cells: role in acute and chronic arthritis. Immunol Rev 2007;217:19-37.
6. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002;297:1689-1692
7. Sandler C, Lindstedt KA, Joutsiniemi S, Lappalainen J, Juutilainen T, Kolah J, et al. Selective activation of mast cells in rheumatoid synovial tissue results in production of TNF-α, IL-1β and IL-1Ra. Inflamm Res 2007;56:230-239 (Pubitemid 47026291)
8. Woolley DE. The mast cell in inflammatory arthritis. N Engl J Med 2003;348:1709-1711
9. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324
10. Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 1999;104:1393-1401
11. Molino M, Raghunath PN, Kuo A, Ahuja M, Hoxie JA, Brass LF, et al. Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1998;18:825-832 (Pubitemid 28267664)
12. Tanaka Y, Wake A, Horgan KJ, Murakami S, Aso M, Saito K, et al. Distinct phenotype of leukemic T cells with various tissue tropisms. J Immunol 1997;158:3822-3829 (Pubitemid 127488740)
13. Abe M, Tanaka Y, Saito K, Shirakawa F, Koyama Y, Goto S, et al. Regulation of interleukin (IL)-1β gene transcription induced by IL-1β in rheumatoid synovial fibroblast-like cells, E11, transformed with simian virus 40 large T antigen. J Rheumatol 1997;24:420-429
14. Van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res 2000;87:335-340
15. Ren XD, Kiosses WB, Schwartz MA. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 1999;18:578-585 (Pubitemid 29057242)
16. Aznar S, Lacal JC. Rho signals to cell growth and apoptosis. Cancer Lett 2001;165:1-10. (Pubitemid 32206651)
17. Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett 2008;582:2093-2101
18. Nakayamada S, Kurose H, Saito K, Mogami A, Tanaka Y. Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts. Arthritis Res Ther 2005;7:R476-84.
19. Yagi Y, Otani H, Ando S, Oshiro A, Kawai K, Nishikawa H, et al. Involvement of Rho signaling in PAR2-mediated regulation of neutrophil adhesion to lung epithelial cells. Eur J Pharmacol 2006;536:19-27.
20. Wakisaka S, Suzuki N, Takeba Y, Shimoyama Y, Nagafuchi H, Takeno M, et al. Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA). Clin Exp Immunol 1998;114:119-128 (Pubitemid 28442823)
21. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases [review]. Am J Physiol 1998;274:C1429-52.
22. Meyer MC, Creer MH, McHowat J. Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. Am J Physiol Cell Physiol 2005;289:C1485-91.
23. Zvaifler NJ, Firestein GS. Pannus and pannocytes: alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 1994;37:783-789 (Pubitemid 24184525)
24. Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, et al. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. Circ Res 2009;104:60-68
25. Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, et al. Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils. Exp Dermatol 2007;16:799-806. (Pubitemid 47377644)
26. Shin K, Nigrovic PA, Crish J, Boilard E, McNeil HP, Larabee KS, et al. Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes. J Immunol 2009;182:647-656
27. Palmer HS, Kelso EB, Lockhart JC, Sommerhoff CP, Plevin R, Goh FG, et al. Protease-activated receptor 2 mediates the proinflammatory effects of synovial mast cells. Arthritis Rheum 2007;56:3532-3540 (Pubitemid 350100686)