Cyclin D1 immunoreactivity in normal endocervix and diagnostic value in reactive and neoplastic endocervical lesions

Modern Pathology

Volumn 23, Issue 4, 2010, Pages 611-618

  Little, Leonie ^a   Stewart, Colin John Reid ^a  

^a KING EDWARD MEMORIAL HOSPITAL   (Australia)

Author keywords

Adenocarcinoma; Cervix; Cyclin D1; Immunohistochemistry; Invasion

Indexed keywords

CYCLIN D1;

ADENOCARCINOMA; ARTICLE; CANCER GRADING; CONTROLLED STUDY; DIAGNOSTIC VALUE; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; METAPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION; UTERINE CERVIX BIOPSY; UTERINE CERVIX TUMOR; UTERINE ENDOCERVIX;

ADENOCARCINOMA; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; CYCLIN D1; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 77950519536     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.178     Document Type: Article

References (34)

1. Schorge JO, Knowles LM, Lea JS. Adenocarcinoma of the cervix. Curr Treat Options Oncol 2004;5:119-127. (Pubitemid 38915116)
2. Bray F, Carstensen B, Moller H, et al. Incidence trends of adenocarcinoma of the cervix in 13 European countries. Cancer Epidemiol Biomarkers Prev 2005;14: 2191-2199. (Pubitemid 41603267)
3. Sasieni P, Castanon A, Cuzick J. Screening and adenocarcinoma of the cervix. Int J Cancer 2009;125: 525-529.
4. Lindeque BG. Management of cervical premalignant lesions. Best Pract Res Clin Obstet Gynaecol 2005;19: 545-561.
5. Zaino RJ. Symposium part I: adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcino-ma of the uterine cervix. Int J Gynecol Pathol 2002;21: 314-326.
6. Young RH, Clement PB. Pseudoneoplastic glandular lesions of the uterine cervix. Semin Diagn Pathol 1991; 8:234-249.
7. Nucci MR. Symposium part III: tumor-like glandular lesions of the uterine cervix. Int J Gynecol Pathol 2002; 21:347-359.
8. McCluggage WG. Immunohistochemistry as a diagnostic aid in cervical pathology. Pathology 2007;39:97-111. (Pubitemid 46310782)
9. Park KJ, Soslow RA. Current concepts in cervical pathology. Arch Pathol Lab Med 2009;133:729-738.
10. Donnellan R, Chetty R. Cyclin D1 and human neoplasia. J Clin Pathol Mol Pathol 1998;51:1-7. (Pubitemid 28157349)
11. Fu M, Wang C, Li Z, et al. Minireview: cyclin D1: normal and abnormal functions. Endocrinol 2004;145: 5439-5447. (Pubitemid 39564581)
12. Kim JK, Diehl JA. Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 2009;220: 292-296.
13. Sherr CJ. The INK4a/ARF network in tumour suppression. Nature Rev Mol Cell Biol 2001;2:731-737.
14. Park JJ, Sun D, Quade BJ, et al. Stratified mucin-producing intraepithelial lesions of the cervix: ade-nosquamous or columnar cell neoplasia? Am J Surg Pathol 2000;24:1414-1419.
15. Young RH, Clement PB. Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis. Histopathology 2002;41:185-207.
16. Li Z, Wang C, Prendergast GC, et al. Cyclin D1 functions in cell migration. Cell Cycle 2006;5: 2440-2442. (Pubitemid 44785818)
17. Cho NH, Kim YT, Kim JW. Correlation between G1 cyclins and HPV in the uterine cervix. Int J Gynecol Pathol 1997;16:339-347.
18. Nichols GE, Williams ME, Gaffey MJ, et al. Cyclin D1 gene expression in human cervical neoplasia. Mod Pathol 1996;9:418-425. (Pubitemid 26153384)
19. Schorge JO, Lea JS, Elias KJ, et al. P16 as a molecular biomarker of cervical adenocarcinoma. Am J Obstet Gynecol 2004;190:668-673.
20. Bae D-S, Cho S-B, Kim Y-J, et al. Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus. Gynecol Oncol 2001;81:341-347.
21. Vijayalakshmi N, Selvaluxmi G, Majhi U, et al. Alterations found in p16/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium. Oncol Res 2007;16:527-533. (Pubitemid 351211325)
22. Queiroz C, Silva TC, Alves VAF, et al. Comparative study of the expression of cellular proteins in cervical intraepithelial lesions. Pathol Res Pract 2006;202: 731-737. (Pubitemid 44382377)
23. Bahnassy AA, Zekri ARN, Saleh M, et al. The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. BMC Clin Pathol 2007;7:4. (Pubitemid 46972613)
24. Cheung TH, Yu MM, Lo KW, et al. Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. Cancer Lett 2001;166:199-206.
25. Conesa-Zamora P, Domenech-Peris A, Orantes-Casado FJ, et al. Effect of human papillomavirus on cell cycle-related proteins p16, Ki-67, cyclin D1, p53, and ProEx C in precursor lesions of cervical carcinoma: a tissue microarray study. Am J Clin Pathol 2009;132:378-390.
26. Kim YT, Zhao M. Aberrant cell cycle regulation in cervical carcinoma. Yonsei Med J 2005;46:597-613. (Pubitemid 41804733)
27. Skomedal H, Forus A, Holm R. Deregulation of D-type cyclins in uterine cancers. Cyclin D1/D3 is differentially expressed in cervical cancer. Anticancer Res 2003;23(5A):3929-3935. (Pubitemid 37474345)
28. Skomedal H, Kristensen GB, Lie AK, et al. Aberrant expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclin D1, RB, and EGFR in cervical carcinomas. Gynecol Oncol 1999;73:223-228. (Pubitemid 29215735)
29. Li W, Thompson CH, Cossart YE, et al. The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil. Head Neck 2004;26:1-9. (Pubitemid 38030143)
30. Andl T, Khan T, Pfuhl A, et al. Etiological involvement of oncogenic human papillomavirus in tonsillar squa-mous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res 1998;58:5-13. (Pubitemid 28027707)
31. Mulvaney NJ, Allen DG, Wilson SM. Diagnostic utility of p16INK4a: a reappraisal of its use in cervical biopsies. Pathology 2008;40:335-344.
32. Rollason TP, Cullimore J, Bradgate MG. A suggested columnar cell morphological equivalent of squamous carcinoma in situ with early stromal invasion. Int J Gynecol Pathol 1989;8:230-236. (Pubitemid 19202341)
33. Stewart CJR, Little L. Immunophenotypic features of MELF pattern invasion in endometrial adenocarcino-ma: evidence for epithelial-mesenchymal transition. Histopathology 2009;55:91-101.
34. Stewart CJR, Crook ML, Leung YC, et al. Expression of cell cycle regulatory proteins in endometrial adeno-carcinoma: variations in conventional tumor areas and in microcystic, elongated and fragmented glands. Mod Pathol 2009;22:725-733.