Aberrant expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclin D1, Rb, and EGFR in cervical carcinomas

Gynecologic Oncology

Volumn 73, Issue 2, 1999, Pages 223-228

  Skomedal, Hanne ^a   Kristensen, Gunnar B ^a   Lie, Agnes Kathrine ^a   Holm, Ruth ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; DOUBLE MINUTE CHROMOSOME; FEMALE; GENE OVEREXPRESSION; GYNECOLOGIC CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; VIRUS CARCINOGENESIS; WART VIRUS;

EID: 0032932656     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1999.5346     Document Type: Article

References (29)

1. Akiyama T, Ohuchi T, Sumida S, Matsumoto K, Toyoshima K: Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci USA 89:7900-7904, 1992
2. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995
3. el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al.: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54:1169-1174, 1994
4. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816, 1993
5. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A: Cloning of p27Kip1, a cyclin-cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8(1):9-22, 1994
6. Slingerland JM, Hengst L, Pan CH, Alexander D, Stampfer MR, Reed SI: A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol Cell Biol 14:3683-3694, 1994
7. Zeng YX, el-Deiry WS: Regulation of p21WAF1/CIP1 expression by p53-independent pathways. Oncogene 12:1557-1564, 1996
8. Shao ZM, Dawson MI, Li XS, Rishi AK, Sheikh MS, Han QX, Ordonez JV, Shroot B, Fontana JA: p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 11:493-504, 1995
9. Jakus J, Yeudall WA: Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells. Oncogene 12:2369-2376, 1996
10. Momand J, Zambetti GP, Olson DC, George D, Levine AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245, 1992
11. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83, 1992
12. Wu X, Levine AJ: p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91:3602-3606, 1994
13. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM: Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375:694-698, 1995
14. Helland A, Holm R, Kristensen G, Kaern J, Karlsen F, Trope C, Nesland JM, Borresen AL: Genetic alterations of the TP53 gene, p53 protein expression and HPV infection in primary cervical carcinomas. J Pathol 171:105-114, 1993
15. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136, 1990
16. Dyson N, Howley PM, Munger K, Harlow E: The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937, 1989
17. Jones DL, Alani RM, Munger K: The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev 11:2101-2111, 1997
18. Zerfass-Thome K, Zwerschke W, Mannhardt B, Tindle R, Botz JW, Jansen-Durr P: Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323-2330, 1996
19. Xu HJ, Hu SX, Cagle PT, Moore GE, Benedict WF: Absence of retinoblastoma protein expression in primary non-small-cell lung carcinomas. Cancer Res 51:2735-2739, 1991
20. Kaplan EL, Meyer P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
21. Tarone RE, Ware J: On distribution-free tests for equlity of survival distributions. Biomedica 64:156-160, 1977
22. Cox DR: Regression Models and Lifetables. J R Stat Soc B, 187-220, 1972
23. Lie AK, Skarsvåg S, Skomedal H, Haugen OA, Holm R: Expression of p53, MDM2 and p21 proteins in high-grade cervical intraepithelial neoplasia. Relationship to human papillomavirus infection. Int J Gynecol Pathol 18(1):5-11, 1999
24. Zhang H, Hannon GJ, Beach D: p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750-1758, 1994
25. Catzavelos C, Bhattacharya N, Ung YC, Wilson JA, Roncari L, Sandhu C, Shaw P, Yeger H, Morava-Protzner I, Kapusta L, Franssen E, Pritchard KI, Slingerland JM: Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat Med 3(2): 227-230, 1997
26. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3(2):231-234, 1997
27. Motokura T, Arnold A: Cyclin D and oncogenesis. Curr Opin Genet Dev 3:5-10, 1993
28. Cho NH, Kim YT, Kim JW: Correlation between G1 cyclins and HPV in the uterine cervix. Int J Gynecol Pathol 16:339-347, 1997
29. Nichols GE, Williams ME, Gaffey MJ, Stoler MH: Cyclin D1 gene expression in human cervical neoplasia. Mod Pathol 9:418-425, 1996