Influence of intestinal efflux pumps on the absorption and transport of furosemide

Saudi Pharmaceutical Journal

Volumn 18, Issue 2, 2010, Pages 97-101

  Al Mohizea, Abdullah M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Furosemide efflux; Furosemide intestinal absorption; Intestinal efflux

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; EXCIPIENT; FUROSEMIDE; GLYCOPROTEIN P; POLYSORBATE 80; PROTEIN INHIBITOR; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG INHIBITION; DRUG TRANSPORT; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PROTEIN FUNCTION; RAT;

EID: 77950488570     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2010.02.005     Document Type: Article

References (15)

1. Bansal T., Singh M., Mishra G., Talegaonkar S., Khar R.K., Jaggi M., and Mukherjee R. Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in caco-2 intestinal absorption studies. J. Chromatogr. B 859 (2007) 261-266
2. Barthe L., Bessouet M., Woodley J.F., and Houin G. The improved everted gut sac: a simple method to study intestinal P-glycoprotein. Int. J. Pharm. 173 (1998) 255-258
3. Berko S., Regdon Jr. G., Ducza E., Falkay G., and Eros I. In vitro and in vivo study in rats of rectal suppositories containing furosemide. Eur. J. Pharm. Biopharm. 53 (2003) 311-315
4. Chungi V.S., Dittert L.W., and Smith R.B. Gastrointestinal sites of furosemide absorption in rats. Int. J. Pharm. 4 (1979) 27-38
5. Hammarlund M.M., Paalzow L.K., and Odlind B. Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis. Eur. J. Clin. Pharmacol. 26 (1984) 197-207
6. Lo Y. Relationship between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in caco-2 cells and rat intestines. J. Control. Release 90 (2003) 37-48
7. Pade V., and Stavchansky S. Link between drug absorption solubility and permeability measurements in caco-2 cells. J. Pharm. Sci. 87 (1998) 1604-1607
8. Pole D.L. Physical and biological considerations for the use of nonaqueous solvents in oral bioavailability enhancement. J. Pharm. Sci. 97 (2008) 1071-1088
9. Polli J.W., Wring S.A., Humphreys J.E., Huang L., Morgan J.B., Webster L.O., and Serabjit-Singh C.S. Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299 (2001) 620-628
10. Rege B.D., Yu L.X., Hussain A.S., and Polli J.E. Effect of common excipients on caco-2 transport of low permeability drugs. J. Pharm. Sci. 90 (2001) 1776-1786
11. Verma M.V.S., and Panchagnula R. Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition from rat in situ permeability. J. Pharm. Sci. 94 (2005) 1694-1704
12. Verma M.V.S., and Panchagnula R. pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs: kinetic analysis of quinidine efflux in situ. J. Pharm. Sci. 94 (2005) 2632-2643
13. Verma M.V.S., Kapoor N., Sarkar M., and Panchagnula R. Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC. J. Chromatogr. B 813 (2004) 352-374
14. Wagner D., Spahn-Langguth H., Hanafy A., Koggel A., and Langguth P. Intestinal drug efflux: formulation and food effects. Adv. Drug Deliv. Rev. 50 (2001) S13-S31
15. Zhang H., Yao M., Morrison R.A., and Chong S. Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats. Arch. Pharm. Res. 26 9 (2003) 768-772