A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 11, 2010, Pages 4943-4948

  Cun, Shujian ^a   Sun, Hongzhe ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bioinorganic chemistry; Bismuth susceptibility; Groes chaperonin; Helicobacter pylori; Natural selection

Indexed keywords

AMINO ACID; ANTIULCER AGENT; BISMUTH; CHAPERONIN; CYSTEINE; METAL; MUTANT PROTEIN; ZINC; ZINC BINDING PROTEIN;

ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; DRUG BINDING SITE; DRUG SENSITIVITY; HELICOBACTER PYLORI; IN VIVO STUDY; METAL BINDING; MUTATION; NATURAL SELECTION; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; BINDING, COMPETITIVE; BISMUTH; CHAPERONIN 10; CYSTEINE; DRUG RESISTANCE; ESCHERICHIA COLI; HELICOBACTER PYLORI; HISTIDINE; KINETICS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; OXIDATION-REDUCTION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SELECTION, GENETIC; ZINC;

HELICOBACTER PYLORI;

EID: 77950433102     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913970107     Document Type: Article

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