Cis lethal genetic interactions attenuate and alter p53 tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 12, 2010, Pages 5511-5515

  Wang, Yuxun ^a,e   Zhang, Weijia ^b   Edelmann, Lisa ^b   Kolodner, Richard D ^c   Kucherlapati, Raju ^d   Edelmann, Winfried ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^d LABORATORY FOR MOLECULAR MEDICINE   (United States)

^e UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

DNA repair; Genome instability; Loss of heterozygosity; Murine model; Tumor suppressor gene

Indexed keywords

PROTEIN; PROTEIN P53; RPA 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA REPAIR; ESSENTIAL GENE; GENE INTERACTION; GENE LOCUS; GENETIC VARIABILITY; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; MISSENSE MUTATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; CROSSES, GENETIC; EPISTASIS, GENETIC; FEMALE; GENES, P53; GENETIC COMPLEMENTATION TEST; GENOMIC INSTABILITY; LOSS OF HETEROZYGOSITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MODELS, GENETIC; MUTATION, MISSENSE; NEOPLASMS, EXPERIMENTAL; PHENOTYPE; REPLICATION PROTEIN A;

MURINAE; MUS;

EID: 77950411083     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001223107     Document Type: Article

References (27)

1. Wold MS (1997) Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem 66:61-92.
2. Haring SJ, Mason AC, Binz SK, Wold MS (2008) Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. J Biol Chem 283: 19095-19111.
3. Wang Y, et al. (2005) Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet 37:750-755. (Pubitemid 41754893)
4. Mackay J, Steel CM, Elder PA, Forrest AP, Evans HJ (1988) Allele loss on short arm of chromosome 17 in breast cancers. Lancet 2:1384-1385.
5. Baker SJ, et al. (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244:217-221.
6. Seitz S, et al. (2001) Detailed deletion mapping in sporadic breast cancer at chromosomal region 17p13 distal to the TP53 gene: Association with clinicopathological parameters. J Pathol 194:318-326. (Pubitemid 32624558)
7. Tharapel SA, Kadandale JS (2002) Primed in situ labeling (PRINS) for evaluation of gene deletions in cancer. Am J Med Genet 107:123-126.
8. Vermeer MH, et al. (2008) Novel and highly recurrent chromosomal alterations in Sézary syndrome. Cancer Res 68:2689-2698.
9. Jacks T, et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4:1-7. (Pubitemid 2027671)
10. Kirsch DG, et al. (2007) A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13:992-997.
11. Popanda O, et al. (2000) Mutation analysis of replicative genes encoding the large subunits of DNA polymerase alpha and replication factors A and C in human sporadic colorectal cancers. Int J Cancer 86:318-324. (Pubitemid 30187490)
12. Michiels S, et al. (2007) Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. Carcinogenesis 28:1731-1739. (Pubitemid 47289035)
13. Abramova NA, Russell J, Botchan M, Li R (1997) Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc Natl Acad Sci USA 94:7186-7191. (Pubitemid 27345290)
14. Fanning E, Klimovich V, Nager AR (2006) A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res 34:4126-4137. (Pubitemid 44542191)
15. Goodrow TL, et al. (1992) Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors. Mol Carcinog 5:9-15.
16. French JE, et al. (2001) Loss of heterozygosity frequency at the Trp53 locus in p53- deficient (+/-) mouse tumors is carcinogen- and tissue-dependent. Carcinogenesis 22: 99-106.
17. Mao JH, et al. (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene 22:8379-8385.
18. Mao JH, et al. (2005) Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene 24:7924-7934.
19. Mao JH, et al. (2007) Crosstalk between Aurora-A and p53: Frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell 11:161-173.
20. Cichowski K, et al. (1999) Mouse models of tumor development in neurofibromatosis type 1. Science 286:2172-2176. (Pubitemid 129516295)
21. Vogel KS, et al. (1999) Mouse tumor model for neurofibromatosis type 1. Science 286: 2176-2179.
22. Chen W, et al. (2004) Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell 6:387-398. (Pubitemid 39361439)
23. Zhu Y, et al. (2005) Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8:119-130. (Pubitemid 41132741)
24. Alcantara Llaguno S, et al. (2009) Malignant astrocytomas originate from neural stem/ progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15:45-56.
25. Biggs PJ, et al. (2003) Allelic phasing of a mouse chromosome 11 deficiency influences p53 tumorigenicity. Oncogene 22:3288-3296.
26. de Smith AJ, et al. (2007) Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: Implications for association studies of complex diseases. Hum Mol Genet 16:2783-2794.
27. Overholtzer M, et al. (2003) The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci USA 100: 11547-11552. (Pubitemid 37205973)