Detailed deletion mapping in sporadic breast cancer at chromosomal region 17p13 distal to the TP53 gene: Association with clinicopathological parameters

Journal of Pathology

Volumn 194, Issue 3, 2001, Pages 318-326

  Seitz, Susanne ^a   Poppe, Konstanze ^a   Fischer, Jörg ^b   Nothnagel, Anita ^a   Estévez Schwarz, Lope ^a,b   Haensch, Wolfgang ^b   Schlag, Peter M ^b   Scherneck, Siegfried ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Section of Pathology   (Germany)

Author keywords

Breast cancer; Chromosomal region 17p13; Clinicopathological parameters; Loss of heterozygosity; TP53

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN P53;

ALLELE; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER SIZE; CELL PROLIFERATION; CHROMOSOME 17P; CHROMOSOME DELETION; CHROMOSOME MAP; CHROMOSOME MARKER; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION FUNCTION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MEDICAL PARAMETERS; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, LOBULAR; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GENE DELETION; GENETIC MARKERS; HUMANS; KI-67 ANTIGEN; LOSS OF HETEROZYGOSITY; LYMPHATIC METASTASIS; MIDDLE AGED; PROGNOSIS; RECEPTORS, ESTROGEN; STATISTICS, NONPARAMETRIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034947206     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(200107)194:3<318::AID-PATH881>3.0.CO;2-4     Document Type: Article

References (39)

1. Genetic alterations in breast cancer
2. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer
3. Detailed mapping and loss of heterozygosity analysis suggest a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3
4. Consortium study on 1280 breast carcinomas: Allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters
5. Suppression of tumorigenicity of breast cancer cells by transfer of human chromosome 17 does not require transferred BRCA1 and p53 genes
6. Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer
7. Loss of heterozygosity on chromosome 17p13 in breast carcinomas identifies tumors with high proliferation index
8. Allelic loss on distal chromosome 17p is associated with poor prognosis in a group of Brazilian breast cancer patients
9. Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes
10. Allelic loss at 1p34, 13q12, 17p13.3 and 17q21.1 correlates with poor postoperative prognosis in breast cancer
11. At last worldwide agreement on the staging of cancer
12. Pathological prognostic factors in breast cancer. The value of histological grade in breast cancer: Experience from a large study with long-term follow up
13. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue
14. Identification of two candidate tumor suppressor genes on chromosome 17p13.3
15. A comprehensive genetic map of the human genome based on 5264 microsatellites
16. Somatic genetic changes in human breast cancer
17. Tumor and growth suppression of breast cancer cells by chromosome 17-associated functions
18. Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis
19. Genetic studies of 457 breast cancers. Clinicopathologic parameters compared with genetic alterations
20. Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations
21. Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas
22. Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 16q, 17p and 17q
23. Allelic deletion on chromosome 17p13.3 in early ovarian cancer
24. Detailed deletion mapping suggest the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers
25. Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors
26. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis
27. Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas
28. Study of allelic losses on 3p, 6q and 17p in human urothelial cancer
29. p53 activates expression of HIC-1, a new candidate tumor suppressor gene on 17p13.3
30. Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer
31. Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells
32. Two species of human CRK cDNA encode proteins with distinct biological activities
33. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
34. Association of genetic alterations on chromosome 17 and loss of hormone receptors in breast cancer
35. P53 gene mRNA expression and chromosome 17p allele loss in breast cancer