Insight in schizophrenia - A comprehensive update

German Journal of Psychiatry

Volumn 13, Issue 1, 2010, Pages 17-30

  Chakraborty, Kaustav ^a   Basu, Debasish ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Insight; Psychosis; Schizophrenia

Indexed keywords

NEUROLEPTIC AGENT;

ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; COGNITION; COGNITIVE THERAPY; CONCEPTUAL FRAMEWORK; DENIAL; DEPRESSION; DISEASE SEVERITY; DISORIENTATION; FRONTAL LOBE; HUMAN; INFORMED CONSENT; INTELLIGENCE QUOTIENT; NEGATIVE SYNDROME; NEUROBIOLOGY; PATIENT ATTITUDE; PATIENT COMPLIANCE; PATIENT EDUCATION; POSITIVE SYNDROME; PSYCHOLOGICAL WELL BEING; PSYCHOPATHY; PSYCHOSIS; QUALITY OF LIFE; SCHIZOPHRENIA; SOCIAL CLASS; SOCIAL PSYCHOLOGY; TREATMENT RESPONSE; VIOLENCE;

EID: 77950406586     PISSN: None     EISSN: 14331055     Source Type: Journal    
DOI: None     Document Type: Article

References (186)

1. Agarwal MR, Sharma VK, Kumar K, Lowe D. Noncompliance with treatment in patients suffering from schizophrenia: a study to evaluate possible contributing factors. Int J Soc Psychiatry 1998; 44: 92-106
2. Aleman A, Agrawal N, Morgan KD, David AS. Insight in psychosis and neuropsychological function: Metaanalysis. Br J Psychiatry 2006; 189: 204-212
3. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, et al. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch Gen Psychiatry 1994; 51: 826-836
4. Amador XF, Friedman JH, Kasapis C, Yale SA, Flaum M, Gorman JM. Suicidal behaviour in schizophrenia and its relationship to awareness of illness. Am J Psychiatry 1996; 153:1185-1188
5. Amador XF, Gorman JM. Psychopathologic domains and insight in schizophrenia. Psychiatr Clin North Am 1998; 21: 27-42
6. Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. The assessment of insight in psychosis. Am J Psychiatry 1993; 150: 873-879
7. Amador XF, David AS (eds). Insight and Psychosis. New York: Oxford University Press; 1998
8. Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. Assessment of insight in psychosis. Am J Psychiatry 1993; 150: 873-879
9. Appelbaum PS, Robbins PC, Monahan J. Violence and delusions: data from the MacArthur Violence Risk Assessment Study. Am J Psychiatry 2000; 157: 566-572
10. Arango C, Barba AC, Gonzalez-Salvador T, Ordonez AC. Violence in inpatients with schizophrenia: a prospective study. Schizophr Bull 1999; 25: 493-503
11. Arango C, Bombin I, Gonzalez-Salvador T, Garcia-Cabeza I, Bobes J. Randomised clinical trial comparing oral versus depot formulations of zuclopenthixol in patients with schizophrenia and previous violence. Eur Psychiatry 2006; 21: 34-40
12. Armstrongh KPL, Chandrasekaran R, Perme B. Insight, Psychopathology and Schizophrenia. Indian J Psychiatry 2002; 44: 332-336
13. Ashburner J, Friston KJ. Voxel-based morphometry - the methods. Neuroimage 2000; 11: 805-821
14. B Saravanan, KS Jacob, M Prince, D Bhugra, AS David. Culture and insight revisited. Br J Psychiatry 2004; 184: 107-109
15. Babinski MJ. Contribution a l'etude des troubles mentaux dans l'hemiplgie organique cerebrale. Revue Neurologique 1914; 1: 845-848
16. Bacon E, Izaute M. Metacognition in schizophrenia: processes underlying patients' reflections on their own episodic memory. Biol Psychiatry 2009, Sep 1. [Epub ahead of print.]
17. Baier M, DeShay E, Owens K, Robinson M, Lasar K, Peterson K, et al. The relationship between insight and der, neuropsychology and insight in schizophrenia. Psychopathology. 2009; 42: 264-269
18. Bassitt DP, Neto MRL, de Castro CC, Busatto GF. Insight and regional brain volumes in schizophrenia. Eur Arch Psychiat Clin Neurosci 2007; 257: 58-62
19. Bayard S, Capdevielle D, Boulenger JP, Raffard S. Dissociating self-reported cognitive complaint from clinical insight in schizophrenia. Eur Psychiatry 2009; 24: 251-258
20. Beck AT, Baruch E, Balter JM, Steer RA, Warman DM. A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophr Res 2004; 68: 319-329
21. Beck-Sander A. Is insight into psychosis meaningful? J Ment Health 1998; 7: 25-34
22. Birchwood M, Smith J, Drury V, Healy J, Macmillan E, Slade MA. A self-report Insight Scale for psychosis; Reliability, validity and sensitivity to change. Acta Psychiatr Scand 1994; 89: 62-27
23. Buchanan A. A two-year prospective study of treatment compliance in patients with schizophrenia. Psychol Med 1992; 22: 789-797
24. Buckley PF, Hrouda DR, Freeman L, Noffsinger SG, Resnick PJ, Camlin-Shinger MSSA. Insight and its relationship to violent behavior in patients with schizophrenia. Am J Psychiatry 2004; 161: 1712-1714
25. Buckley PF, Noffsinger SG, Smith DA, Hrouda DR, Knoll JL. Treatment of the psychotic patient who is violent. Psychiatr Clin North Am 2003; 26: 231-272
26. Buckley PF, Wirshing DA, Bhushan P, Pierre JM, Resnick SA, Wirshing WC. Lack of insight in schizophrenia: impact on treatment adherence. CNS Drugs 2007; 21: 129-141
27. Capdevielle D, Raffard S, Bayard S, Garcia F, Baciu O, Bouzigues I. Competence to consent and insight in schizophrenia: Is there an association? A pilot study. Schizophr Res 2009; 108: 272-279
28. Carpenter WT, Strauss, JS, Bartko JJ. Flexible system for the diagnosis of schizophrenia: Report from the WHO international pilot study of schizophrenia. Science 1973; 182: 1275-1278
29. Carroll A, Fattah S, Clyde Z, Coffey I, Owens DGC, Johnstone EC. Correlates of insight and insight change in schizophrenia. Schizophr Res 1999; 35: 247-253
30. Carroll A, Pantelis C, Harvey C. Insight and hopelessness in forensic patients with schizophrenia. Aust N Z J Psychiatry 2004; 38: 169-173
31. Cernovsky ZZ, Landmark J, Helmes E. Are schizophrenic symptoms different in patients with higher education? Psychol Rep 1994; 75: 1552-1554
32. Chen EY-H. Insight and symptoms of psychosis: a prospective inpatient study. Schizophr Res 1998; 29: 34
33. Chen KC, Chu CL, Yang YK, Yeh TL, Lee IH, Chen PS, et al. The relationship among insight, cognitive function of patients with schizophrenia and their relatives' perception. Psychiatry Clin Neurosci 2005; 59: 657-660
34. Chen EY, Kwok CL, Chen RY, Kwong PP. Insight changes in acute psychotic episodes: a prospective study of Hong Kong Chinese patients. J Nerv Ment Dis 2001; 189: 24-30
35. Cheung P, Schweitzer I, Crowley K, Tuckwell V. Violence in schizophrenia: role of hallucinations and delusions. Schizophr Res 1997; 26:181-190
36. Coldham EL, Addington J, Addington D. Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand 2002; 106: 286-290
37. Collins AA, Remington GJ, Coulter K, Birkett K. Insight, neurocognitive function and symptom clusters in chronic schizophrenia. Schizophr Res 1997; 27: 37-44
38. Cooke MA, Fannon D, Kuipers E, Peters E, Williams S, Kumari V. Neurological basis of poor insight in psychosis: A voxel-based MRI study. Schizophr Res 2008; 103: 40-51
39. Cuesta MJ, Peralta V, Zarzuela A. Psychopathological dimensions and lack of insight in schizophrenia. Psychol Rep 1998; 83: 895-898
40. Cuesta MJ, Peralta V. Lack of insight in schizophrenia. Schizophr Bull 1994; 20: 359-366
41. Cuesta MJ, Peralta V, Caro F, de Leon J. Is poor insight in psychotic disorders associated with poor performance on the Wisconsin card sorting test? Am J Psychiatr 1995; 152: 1380-1382
42. Cuffel BJ, Alford J, Fischer EP, Owen RR. Awareness of illness in schizophrenia and outpatient treatment adherence. J Nerv Ment Dis. 1996; 184: 653-659
43. David A, Buchanan A, Reed A, Almeida O. The assessment of insight in psychosis. Br J Psychiatry 1992; 161: 599-602
44. David AS, van Os J, Jones P, Harvey I, Forester A, Fahy T, et al. Insight and psychotic illness: cross-sectional and longitudinal associations. Br J Psychiatry 1995; 167: 621-628
45. David AS. Insight and psychosis. Br J Psychiatry 1990; 156: 798-808
46. David AS. "To see ourselves as others see us". Aubrey Lewis's insight. Br J Psychiatry 1999; 175: 210-216
47. Davidhizar RE, Austin JK, McBride AB. Attitudes of patients with schizophrenia toward taking medication. Res Nurs Health 1986; 9: 139-146
48. Day JC, Bentall R, Roberts C, Randall F, Rogers A, Cattell D, et al. Attitudes toward antipsychotic medication the impact of clinical variables and relationships with health professionals. Arch Gen Psychiatry 2005; 62: 717-724
49. De Hert MAF, Simon V, Vidovic D, Franic T, Wampers M, Peuskens J. Evaluation of the association between insight and symptoms in a large sample of patients with schizophrenia. Eur Psychiatry 2009 Jun 18. [Epub ahead of print]
50. Dickerson FB, Boronow JJ, Ringel N, Parente F. Lack of insight among outpatients with schizophrenia. Psychiatr Serv 1997; 48: 195-199
51. Donohoe G, Owens N, O'Donnell C, Burke T, Moore L, Tobin A, et al. Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analyses. Eur Psychiatry 2001; 16: 293-298
52. Drake RJ. Insight into illness: impact on diagnosis and outcome of nonaffective psychosis. Curr Psychiatry Rep 2008; 10: 210-216
53. Drake RJ, Lewis SW. Insight and neurocognition in schizophrenia. Schizophr Res 2003; 62: 165-173.
54. Dunn LB, Roberts LW. Emerging findings in ethics of schizophrenia research. Curr Opin Psychiatry 2005; 18:111-119
55. Dunn LB, Palmer BW, Appelbaum PS, Saks ER, Aarons GA, Jeste DV. Prevalence and correlates of adequate performance on a measure of abilities related to decisional capacity: differences among three standards for the MacCAT-CR in patients with schizophrenia. Schizophr Res 2007; 89:110-118
56. Endicott J, Nee J, Fleiss J, Cohen J, Williams JB, Simon R. Diagnostic criteria for schizophrenia: reliabilities and agreement between systems. Arch Gen Psychiatry 1982; 39: 884-889
57. Evren C, Evren B. Characteristics of schizophrenic patients with a history of suicide attempt. Int J Psychiatry Clin Pract 2004; 8: 227-234
58. Flashman LA, McAllister TW, Andreasen NC, Saykin AJ. Smaller brain size associated with unawareness of illness in patients with schizophrenia. Am J Psychiatry 2000; 157: 1167-1169
59. Flashman LA, McAllister TW, Johnson SC, Rick JH, Green RL, Saykin AJ. Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study. J Neuropsychiatry Clin Neurosci 2001; 13: 255-257
60. Foley S, Kelly BD, Clarke M, McTigue O, Gervin M, Kamali M, et al. Incidence and clinical correlates of aggression and violence at presentation in patients with first episode psychosis. Schizophr Res 2005; 72: 161-168
61. Freud S 1933. The dissection of the psychical personality. Standard Edition (1964), vol 22, pp. 57-80, London: Hogarth Press
62. Froböse T, Pitschel-Walz G, Bäuml J. Lack of insight into illness of schizophrenia patients from their relatives' perspective. Psychiatr Prax 2009 Sep 21. [Epub ahead of print]
63. Gambini O, Barbieri V, Scarone S. Theory of mind in schizophrenia: first person vs third person perspective. Conscious Cogn 2004; 13: 39-46
64. Garavan J, Browne S, Gervin M, Lane A, Larkin C, O'Callaghan E. Compliance with neuroleptic medication in outpatients with schizophrenia; relationship to subjective response to neuroleptics; attitudes to medication and insight. Compr Psychiatry 1998; 39: 215-219
65. Gharabawi GM, Lasser RA, Bossie CA, Zhu Y, Amador X. Insight and its relationship to clinical outcomes in patients with schizophrenia or schizoaffective disorder receiving long-acting risperidone. Int Clin Psychopharmacol 2006; 21: 233-240
66. Goldberg RW, Green-Paden LD, Lehman AF, Gold JM. Correlates of insight in serious mental illness. J Nerv Ment Dis 2001; 189: 137-145
67. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21-36
68. Goodman C, Knoll G, Isakov V, Silver H. Insight into illness in schizophrenia. Compr Psychiatry 2005; 46: 284-290
69. Grevatt A, Thomas-Peter B, Hughes G. Violence, mental disorder and risk assessment: can structured clinical assessments predict the short-term risk of inpatient violence? J Forensic Psychiatry Psychol 2004; 15: 278-292
70. Grisso T, Appelbaum PS. Comparison of standards for assessing patients' capacities to make treatment decisions. Am J Psychiatry 1995; 152: 1033-1037
71. Grisso T, Appelbaum PS, Hill-Fotouhi C. The MacCAT-T: a clinical tool to assess patient's capacities to make treatment decisions. Psychiatr Serv 1997; 48: 1415-1419
72. Ha TH, Youn T, Ha KS, Rho KS, Lee JM, Kim IY, et al. Gray matter abnormalities in paranoid schizophrenia and their clinical correlations. Psychiatry Res 2004; 132: 251-260
73. Harre L, Lamb R (eds). Encyclopaedic Dictionary of Psychology. Oxford: Basil Blackwell; 1983
74. Hasson-Ohayon I, Kravetz S, Meir T, Rozencwaig S. Insight into severe mental illness, hope, and quality of life of persons with schizophrenia and schizoaffective disorders. Psychiatry Res 2009; 167: 231-238
75. Hasson-Ohayon I, Kravetz S, Roe D, David AS, Weiser M. Insight into psychosis and quality of life. Compr Psychiatry 2006; 47: 265-269
76. Heinrichs DW, Cohen BR, Carpenter WT. Early insight and the management of schizophrenic decompensation. J Nerv Ment Dis 1985; 173: 133-138
77. Hwang SH, Chang JS, Lee KY, Ahn YM, Kim YS. The Causal Model of Insight in Schizophrenia Based on the Positive and Negative Syndrome Scale Factors and the Structural Equation Modeling. J Nerv Ment Dis 2009; 197: 79-84
78. Iqbal Z, Birchwood M, Chadwick P, Trower P. Cognitive approach to depression and suicidal thinking in psychosis - 2. Testing the validity of a social ranking model. Br J Psychiatry 2000; 177: 522-528
79. Jaspers K (1913). General Psychopathology (trans. J Hoenig, MW Hamilton). Manchester: Manchester University Press; 1963
80. Jørgensen P. Recovery and insight in schizophrenia. Acta Psychiatr Scand 1995; 92: 436-440
81. Kamali M, Kelly BD, Clarke M, Browne S, Gervin M, Kinsella A, et al. A prospective evaluation of adherence to medication in first episode schizophrenia. Eur Psychiatry 2006; 21: 29-33
82. Kamali M, Kelly L, Gervin M, Browne S, Larkin C, O'Callaghan E. Insight and comorbid substance misuse and medication compliance among patients with schizophrenia. Psychiatr Serv 2001; 52: 161-166
83. Kemp R, David A. Psychological predictors of insight and compliance in psychotic patients. Br J Psychiatry 1996; 169: 444-450
84. Kemp R, Hayward P, Applewhaite G, Everitt B, David A. Compliance therapy in psychotic patients: randomised controlled trial. BMJ 1996; 312: 345-349
85. Kemp RA, Lambert TJ. Insight in schizophrenia and its relationship to psychopathology. Schizophr Res 1995; 18: 21-28
86. Keshavan MS, Rabinowitz J, DeSmedt G, Harvey PD, Schooler N. Correlates of insight in first episode psychosis. Schizophr Res 2004; 70: 187-194
87. Kim C-H, Jayathilake K, Meltzer HY. Hopelessness, neurocognitive function. insight in schizophrenia: relationship to suicidal behavior. Schizophr Res 2003; 60: 71-80
88. Kleinman, A. Patients and Healers in the Context of Culture. Berkeley, CA: University of California Press; 1980
89. Koren D, Seidman LJ, Poyurovsky M, Goldsmith M, Viksman P, Zichel S. The neuropsychological basis of insight in first-episode schizophrenia: a pilot metacognitive study. Schizophr Res 2004; 70: 195-202
90. Koriat A, Goldsmith M. Monitoring and control processes in the strategic regulation of memory accuracy. Psychol Rev 1996; 103: 490-517
91. Kozuki Y, Froelicher ES. Lack of awareness and nonadherence in schizophrenia. West J Nurs Res 2003; 25: 57-74
92. Kulhara P, Chakrabarti S, Basu D. Insight & psychosis: an empirical inquiry. Indian J Soc Psychiatry 1992; 8: 40-44
93. Lally SJ. "Does being in here mean there is something wrong with me"? Schizophr Bull 1989; 15: 253-265
94. Langdon R, Ward P. Taking the perspective of the other contributes to awareness of illness in schizophrenia. Schizophr Bull 2009; 35: 1003-1011
95. Laroi F, Fannemel M, Ronneberg U, Flekkoy K, Opjordsmoen S, Dullerud R, et al. Unawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests. Psychiatry Res 2000; 100: 49-58
96. Lewis A. The psychopathology of insight. Br J Med Psychol 1934; 14: 332-348
97. Lin IE, Spiga R, Fortsch W. Insight and adherence to medication in chronic schizophrenics. J Clin Psychiatry 1979; 40: 430-432
98. Lincoln TM, Lullmann E, Rief W. Correlates and Long-Term Consequences of Poor Insight in Patients with Schizophrenia: A Systematic Review. Schizophr Bull 2007; 33: 1324-1342
99. Link B, Cullen FT, Frank J, Wozniak JF. The social rejection of former mental patients: understanding why labels matter. Am J Sociology 1987; 92: 1461-1500
100. Lishman WA. Organic Psychiatry. Oxford: Blackwell Scientific; 1987
101. Lysaker P, Bryson GJ, Bell MD. Insight and work performance in schizophrenia. J Nerv Ment Dis 2002; 190: 142-146
102. Lysaker PH, Carcione A, Dimaggio G, Johannesen JK, Nicolo G, Procacci M, et al. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatr Scand 2005; 112: 64-71
103. Lysaker PH, Bell MD. Insight and cognitive impairment in schizophrenia: performance on repeated administrations of the Wisconsin Card Sorting Test. J Nerv Ment Dis 1994; 182: 656-660
104. Lysaker PH, Bell MD, Bryson G, Kaplan E. Neurocognitive function and insight in schizophrenia: support for an association with impairments in prefrontal function but not with impairments in global function. Acta Psychiatr Scand 1998; 9: 297-301
105. Lysaker PH, Bryson GJ, Lancaster RS, Evans JD, Bell MD. Insight in schizophrenia: associations with executive function and coping style. Schizophr Res 2002; 59: 41-47
106. Lysaker PH, Lancaster RS, Davis LW, Clements CA. Patterns of neurocognitive deficits and unawareness of illness in schizophrenia. J Nerv Ment Dis 2003; 191: 38-44
107. Lysaker PH, Buck KD, Salvatore G, Popolo R, Dimaggio G. Lack of awareness of illness in schizophrenia: conceptualizations, correlates and treatment approaches. Expert Rev Neurother. 2009; 9:1035-1043
108. Macpherson R, Jerrom B, Hughes A. Drug refusal among schizophrenic patients treated in the community. J Ment Health 1997; 6: 141-147
109. Markova IS, Berrios GE. Insight in clinical psychiatry. J Nerv Ment Dis 1995; 183: 743-751
110. Markova IS, Berrios GE. The meaning of insight in clinical psychiatry. Br J Psychiatry 1992; 160: 850-860
111. Markova IS, Berrios GE. The assessment of insight in clinical psychiatry: A new scale. Acta Psychiatr Scand 1992; 86:159-164
112. Marks KA, Fastenau PS, Lysaker PH, Bond GR. Self Appraisal of Illness Questionnaire (SAIQ): relation ship to researcher-rated insight and neuropsychological function in schizophrenia. Schizophr Res 2000; 27: 203-211
113. McCabe R, Quayle E, Beirne AD, Ann Duane MM. Insight, global neuropsychological functioning, and symptomatology in chronic schizophrenia. J Nerv Ment Dis 2002; 190: 519-525
114. McEvoy JP, Apperson LJ, Applebaum PS, Ortlip P, Brecosky J, Hammill K, et al. Insight in schizophrenia. Its relationship to acute psychopathology. J Nerv Ment Dis 1989; 177: 43-47
115. McEvoy JP, Freter S, Everett G, Geller JL, Appelbaum P, Apperson LJ, et al. Insight and the clinical outcome of schizophrenic patients. J Nerv Ment Dis 1989; 177: 48-51
116. McEvoy JP, Freter S, Merritt M, Apperson LJ. Insight about psychosis among outpatients with schizophrenia. Hosp Community Psychiatry 1993; 44: 883-884
117. McEvoy JP, Hartman M, Gottlieb D, Godwin S, Apperson LJ, Wilson W. Common sense, insight and neuropsychological test performance in schizophrenic patients. Schizophr Bull 1996; 22: 635-641
118. McEvoy LR, Aland J, Wilson WH, Guy W, Hawkins L. Measuring chronic schizophrenic patients' attitudes toward their illness and treatment. Hosp Community Psychiatry 1981; 32: 856-858
119. McGlashan TH, Carpenter Jr WT. Postpsychotic depression in schizophrenia. Arch Gen Psychiatry 1976; 33: 231-239
120. McGlashan TH, Levy ST, Carpenter Jr WT. Integration and sealing over. Clinically distinct recovery styles from schizophrenia. Arch Gen Psychiatry 1975; 32: 1269-1272
121. McGlynn SM, Schacter DL.Unawareness of deficits in neuropsychological syndromes. J Clin Exp Neuropsychol 1989; 11: 143-205
122. McIntosh AM, Conlon L, Lawrie SM, Stanfield AC. Compliance therapy for schizophrenia. Cochrane Database Syst Rev 2006; 3: CD003442
123. McLeod HJ, Coertze L, Moore E. The relationship between insight and social rank appraisals in people with schizophrenia. Br J Clin Psychol 2009; 48(Pt 3): 329-334
124. Mehrotra S, Sengupta S. Insight and Psychopathology in Schizophrenia: A Four-Week Longitudinal Study. German J Psychiatry 2006; 9: 48-52
125. Michalakeas A, Skoutas C, Charalambous A, Peristeris A, Marinos V, Keramari E, et al. Insight in schizophrenia and mood disorders and its relation to psychopathology. Acta Psychiatr Scand 1994; 90: 46-9
126. Miller L. Freud's Brain: The Neuropsychodynamic Foundation of Psychoanalysis. New York: Guilford Press; 1991
127. Mintz AR, Addington J, Addington D. Insight in early psychosis: a 1-year follow-up. Schizophr Res 2004; 67: 213-217
128. Mintz AR, Dobson KS, Romney DM. Insight in schizophrenia: a metaanalysis. Schizophr Res 2003; 61: 75-88
129. Mohamed S, Fleming S, Penn DL, Spaulding W. Insight in schizophrenia: its relationship to measures of prefrontal functions. J Nerv Ment Dis 1999; 187: 525-531
130. Mohamed S, Rosenheck R, McEvoy J, Swartz M, Stroup S, Lieberman JA. Cross-sectional and longitudinal relationships between insight and attitudes toward medication and clinical outcomes in chronic schizophrenia. Schizophr Bull 2009; 35: 336-346
131. Moore A, Sellwood W, Stirling J. Compliance and psychological reactance in schizophrenia. Br J Clin Psychol 2000; 39: 287-295
132. Moore O, Cassidy E, Carr A, O'Callaghan E. Unawareness of illness and its relationship with depression and self-deception in schizophrenia. Eur Psychiatry 1999; 14: 264-269
133. Moser DJ, Schultz SK, Arndt S, Benjamin ML, Fleming FW, Brems CS, et al. Capacity to provide informed consent for participation in schizophrenia and HIV research. Am J Psychiatry 2002; 159: 1201-1207
134. Mutsatsa SH, Joyce EM, Hutton SB, Webb E, Gibbins H, Paul S et al. Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatr Scand 2003; 108: 439-446
135. Nelson AA, Gold BH, Hutchinson RA, Benezra E. Drug default among schizophrenic patients. Am J Hosp Pharm 1975; 32: 1237-1242
136. Osatuke K, Ciesla J, Kasckow JW, Zisook S, Mohamed S. Insight in schizophrenia: a review of etiological models and supporting research. Compr Psychiatry 2008; 49: 70-77
137. Palmer BW, Jeste DV. Relationship of individual cognitive abilities to specific components of decisional capacity among middle- aged and older patients with schizophrenia. Schizophr Bull 2006; 32: 98-106
138. Parellada M, Fraguas D, Bombín I, Otero S, CastroFornieles J, Baeza I, et al. Insight correlates in child and adolescent-onset first episodes of psychosis: results from the CAFEPS study. Psychol Med 2009; 39: 1433-1445
139. Perkins R, Moodley P. The arrogance of insight? Psychiatr Bull 1993; 17: 233-234
140. Raffard S, Bayard S, Gely-Nargeot M, Capdevielle D, Maggi M, Barbotte E. Insight and executive functioning in schizophrenia: A multidimensional approach. Psychiatry Res 2009; 167: 239-250
141. Rathod S, Turkington D. Cognitive-behaviour therapy for schizophrenia: a review. Curr Opin Psychiatry 2005; 18: 159-163
142. Reid JR, Finesinger JE. The role of insight in Psychotherapy. Am J Psychiatry 1952; 108: 726-734
143. Robinson MF, Freeman W. Psychosurgery and the self. New York: Grune and Stratton; 1954
144. Rossell SL, Coakes J, Shapleske J, Woodruff PWR, David AS. Insight: its relationship with cognitive function, brain volume, and symptoms in schizophrenia. Psychol Med 2003; 33:111-119
145. Rüsch N, Todd AR, Bodenhausen GV, Weiden PJ, Corrigan PW. Implicit versus explicit attitudes toward psychiatric medication: Implications for insight and treatment adherence. Schizophr Res 2009; 112: 119-122
146. Sanz M, Constable G, Lopez-Ibor I, Kemp R, David AS. A comparative study of insight scales and their relationship to psychopathological and clinical variables. Psychol Med 1998; 28: 437-446
147. Sapara A, Cooke MA, Fannon D, Francis A, Buchanan RW, Anilkumar AP, et al. Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophr Res 2007; 89: 22-34.
148. Saravanan B, Jacob KS, Johnson S, Prince M, Bhugra D, David AS. Assessing insight in schizophrenia: East meets West. Br J Psychiatry 2007; 190: 243-247
149. Schennach-Wolff R, Jäger M, Seemüller F, Obermeier M, Messer T, Laux G, et al. Attitude towards adherence in patients with schizophrenia at discharge. J Psychiatr Res 2009 Jun 6. [Epub ahead of print]
150. Schwartz RC, Petersen S. The relationship between insight and suicidality among patients with schizophrenia. J Nerv Ment Dis 1999; 187: 376-378
151. Schwartz RC, Smith SD. Suicidality and psychosis: the predictive potential of symptomatology and insight into illness. J Psychiatr Res 2004; 38: 185-191
152. Schwartz RC. Insight and suicidality in schizophrenia: a replication study. J Nerv Ment Dis 2000; 188: 235-237
153. Sevy S, Nathanson K, Visweswaraiah H, Amador X. The relationship between insight and symptoms in schizophrenia. Compr Psychiatry 2004; 45: 16-19
154. Shad MU, Keshavan MS, Tamminga CA, Cullum CM, David A. Neurobiological underpinnings of insight deficits in schizophrenia. Int Rev Psychiatry 2007; 19: 437-446
155. Shad MU, Muddasani S, Keshavan MS. Prefrontal sub regions and dimensions of insight in first-episode schizophrenia - a pilot study. Psychiat Res 2006; 146: 35-42
156. Shad MU, Muddasani S, Sahni SD, Keshavan MS. Insight and Prefrontal Cortex in First-episode Schizophrenia. NeuroImage 2004; 22: 1315-1320
157. Sim K, Chan YH, Chua TH, Mahendran R, Chong SA, McGorry P. Physical comorbidity, insight, quality of life and global functioning in first episode schizophrenia: a 24-month, longitudinal outcome study. Schizophr Res 2006; 88: 82-89
158. Simon V, De Hert M, Wampers M, Peuskens J, van Winkel R. The relation between neurocognitive dysfunction and impaired insight in patients with schizophrenia. European Psychiatry 2009; 24: 239-243
159. Smith CM, Barzman D, Pristach CA. Effect of patient and family insight on compliance of schizophrenic patients. J Clin Pharmacol 1997; 37: 147-154
160. Smith TE, Hull JW, Goodman M, Hedayat-Harris A, Willson DF, Israel LM, et al. The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. J Nerv Ment Dis 1999; 187: 102-108
161. Smith TE, Hull JW, Israel LM, Willson DF. Insight, symptoms, and neurocognition in schizophrenia and schizoaffective disorder. Schizophr Bull 2000; 26:193-200
162. Smith TE, Hull JW, Santos L. The relationship between symptoms and insight in schizophrenia: a longitudinal perspective. Schizophr Res 1998; 33: 63-67
163. Staring AB, Van der Gaag M, Van den Berge M, Duivenvoorden HJ, Mulder CL. Stigma moderates the associations of insight with depressed mood, low self-esteem, and low quality of life in patients with schizophrenia spectrum disorders. Schizophr Res. 2009 Jul 16. [Epub ahead of print]
164. Startup M. Awareness of own and others' schizophrenic illness. Schizophr Res 1997; 26: 203-211
165. Startup M. Insight and cognitive deficits in schizophrenia: evidence for a curvilinear relationship. Psychol Med 1996; 26: 1277-1281
166. Strand S, Belfrage H, Fransson G, Levander S. Clinical and risk management factors in risk prediction of mentally disordered offenders-more important than historical data? Legal Criminol Psychol 1999; 4: 67-76
167. Stuss DT, Benson DF. The Frontal Lobes. New York: Raven Press; 1986
168. Swartz MS, Swanson JW, Hiday VA, Borum R, Wagner R, Burns BJ. Violence and severe mental illness: the effects of substance abuse and nonadherence to medication. Am J Psychiatry 1998; 155: 226-231
169. Tait L, Birchwood M, Trower P. Predicting engagement with services for psychosis: insight, symptoms and recovery style. Br J Psychiatry 2003; 182: 123-128
170. Takai A, Uematsu M, Ueki H, Sone K. Insight and its related factors in chronic schizophrenic patients: a preliminary study. Eur J Psychiatry 1992; 6: 159-170
171. Tharyan A, Saravanan B. Insight and psychopathology in schizophrenia. Indian J Psychiatry 2000; 42: 421-426
172. Tirupati S, Padmavati R, Thara R, McCreadie RG. Insight and psychopathology in never-treated schizophrenia. Compr Psychiatry 2007; 48: 264-268
173. Van Putten T, Crumptom E, Yale C. Drug refusal in schizophrenia and the wish to be crazy. Arch Gen Psychiatry 1976; 33: 1443-1446
174. Voruganti LN, Heslegrave RJ, Awad AG. Neurocognitive correlates of positive and negative syndromes in schizophrenia. Can J Psychiatry 1997; 42: 1066-1071
175. Warner R, Taylor D, Powers M, Hyman J. Acceptance of the mental illness label by psychotic patients: Effects on functioning. American Journal of Orthopsychiatry 1989; 59: 398-409
176. Watson PWP, Garety PA, Weinman J, Dunn G, Bebbington PE, Fowler D, et al. Emotional dysfunction in schizophrenia spectrum psychosis: the role of illness perceptions. Psychol Med 2006; 36:761-770
177. Weiler MA, Fleisher MH, McArthur-Campbell D. Insight and symptom change in schizophrenia and other disorders. Schizophr Res 2000; 45: 29-36
178. Wing JK, Cooper JE, Sartorius N. Measurement and classification of psychiatric symptoms: an instruction manual for the PSE and catego programme. Cambridge, England: Cambridge University Press; 1974
179. Wittorf A, Jakobi U, Bechdolf A, Müller B, Sartory G, Wagner M, et al. The influence of baseline symptoms and insight on the therapeutic alliance early in the treatment of schizophrenia. Eur Psychiatry 2009; 24: 259-267
180. Wong JG, Cheung EP, Chen EY. Decision-making capacity of inpatients with schizophrenia in Hong Kong. J Nerv Ment Dis 2005; 193: 316-322
181. Yen CF, Chen CS, Ko CH, Yeh ML, Yang SJ, Yen JY, et al. Relationships between insight and medication adherence in outpatients with schizophrenia and bipolar disorder: a prospective study. Psychiatry Clin Neurosci 2005; 59: 403-409
182. Yen CF, Yeh ML, Chen CS, Chung HH. Predictive value of insight for suicide, violence, hospitalization, and social adjustment for outpatients with schizophrenia: a prospective study. Compr Psychiatry 2002; 43: 443-447
183. Yoshizumi M, Hirao K, Ueda K, Murai T. Insight in social behavioral dysfunction in schizophrenia: Preliminary study. Psychiatry Clin Neurosci 2008; 62: 669-676
184. Young DA, Davila R, Scher H. Unawareness of illness and neuropsychological performance in schizophrenia. Schizophr Res 1993; 10: 117-124
185. Young DA, Konstantine KZ, Bailey C, Davila R, Griese J, Sartory G, et al. Further parameters of insight and neuropsychological deficit in schizophrenia and other chronic mental disease. J Nerv Ment Dis 1998; 186: 44-50
186. Zygmunt A, Olfson M, Boyer CA, Mechanic D. Interventions to improve medication adherence in schizophrenia. Am J Psychiatry 2002; 159: 1653-1664