Proinsulin C-peptide antagonizes the profibrotic effects of TGF-β1 via up-regulation of retinoic acid and HGF-related signaling pathways

Molecular Endocrinology

Volumn 24, Issue 4, 2010, Pages 822-831

  Hills, Claire E ^a   Willars, Gary B ^a   Brunskill, Nigel J ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; C PEPTIDE; CELLULAR RETINOIC ACID BINDING PROTEIN II; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN; RETINOIC ACID RECEPTOR BETA; SCATTER FACTOR; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ARTICLE; CELL LINE; CELL PROTECTION; CELL STRUCTURE; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; MICROARRAY ANALYSIS; PATHOPHYSIOLOGY; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

BETA CATENIN; C-PEPTIDE; CELL LINE; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, PHASE-CONTRAST; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; TRETINOIN; VIMENTIN;

GASTROPODA;

EID: 77950385843     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0391     Document Type: Article

References (43)

1. Anonymous executive summary 2009 Standards of medical care in diabetes. Diabetes Care 32:S6-S12
2. Rubenstein AH, Melani F, Pilkis S, Steiner DF 1969 Proinsulin: secretion, metabolism, immunological and biological properties. Postgrad Med J(Suppl)45:476-481
3. Ekberg K, Johansson BL 27 December 2007 Effect of C-peptide on diabetic neuropathy in patients with type 1 diabetes. Exp Diabetes Res 10.1155/2008/457912
4. Huang DY, Richter K, Breidenbach A, Vallon V 2002 Human C-peptide acutely lowers glomerular hyperfiltration and proteinuria in diabetic rats: a dose response study. Naunyn Schmiedebergs Arch Pharmacol 365:67-73
5. Samnegård B, Jacobson SH, Jaremko G, Johansson BL, Sjöquist M 2001 Effects of C-peptide on glomerular size and renal function in diabetic rats. Kidney Int 60:1258-1265
6. Sjöquist M, Huang W, Johansson BL 1998 Effects of C-peptide on renal function at the early stage of experimental diabetes. Kidney Int 54:758-764
7. Hills CE, Al-Rasheed N, Al-Rasheed N, Willars GB, Brunskill NJ 2009 C-peptide reverses TGF-β1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. Am J Physiol Renal Physiol 296:F614-F621
8. Burns WC, Twigg SM, Forbes JM, Tikellis C, Thallas-Bonke V, Thomas MC, Cooper ME, Kantharidis P 2006 Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial to mesenchymal transition: implications for diabetic renal disease. J Am Soc Nephrol 7:2484-2494
9. Oldfield MD, Bach LA, Forbes JM, Nikolic-Paterson D, McRobert A, Thallas V, Atkins RC, Osicka T, Jerums G, Cooper ME 2001 Avanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest 108:1853-1863
10. Al-Rasheed NM, Meakin F, Royal EL, Lewington AJ, Brown J, Willars GB, Brunskill NJ 2004 Potent activation of multiple signalling pathways by C peptide in opossum kidney proximal tubular cells. Diabetologia 47:987-997
11. Al-Rasheed NM, Chana RS, Baines RJ, Willars GB, Brunskill NJ 2004 Ligand-independent activation of peroxisome proliferator-activated receptor-γ by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity. J Biol Chem 279:49747-49754
12. Hills CE, Brunskill NJ 2008 Intracellular signalling by C-peptide. Exp Diabetes Res 635158
13. Mizuno S, Matsumoto K, Nakamura T 2001 Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int 59:1304-1314
14. Yang J, Liu Y 2002 Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13:96-107
15. Liu Y 2002 Hepatocyte growth factor and the kidney. Curr Opin Nephrol Hypertens 11:23-30
16. Wen X, Li Y, Hu K, Dai C, Liu Y 2005 Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol 167:947-957
17. Delva L, Bastie JN, Rochette-Egly C, Kraïba R, Balitrand N, Despouy G, Chambon P, Chomienne C 1999 Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex. Mol Cell Biol 19:7158-7167
18. Kim K, Lu Z, Hay ED 2002 Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26:463-476
19. Peinado H, Quintanilla M, Cano A 2003 Transforming growth factor β1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113-21123
20. Ziyadeh FN 1993 The extracellular matrix in diabetic nephropathy. Am J Kidney Dis 22:736-744
21. Kalluri R, Neilson EG 2003 Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-1784
22. Thiery JP 2003 Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746
23. Masszi A, Fan L, Rosivall L, McCulloch CA, Rotstein OD, Mucsi I, Kapus A 2004 Integrity of cell-cell contacts is a critical regulator of TGF-β 1-induced epithelial-to-myofibroblast transition: role for β-catenin. Am J Pathol 165:1955-1967
24. Zeisberg M, Kalluri R 2004 The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82:175-181
25. Rebsomen L, Khammar A, Raccah D, Tsimaratos M 2008 C-Peptide effects on renal physiology and diabetes. Exp Diabetes Res 281536
26. Ekberg K, Brismar T, Johansson BL, Lindström P, Juntti-Berggren L, Norrby A, Berne C, Arnqvist HJ, Bolinder J, Wahren J 2007 C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy. Diabetes Care 30:71-76
27. Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN 2001 The key role of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Ren Fail 23:471-481
28. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR 2008 Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med 233:4-11
29. Sharma K, Ziyadeh FN 1995 Hyperglycaemia and diabetic kidney disease. The case for transforming growth factor-β as a key mediator. Diabetes 44:1139-1146
30. Qi W, Chen X, Zhang Y, Waltham M, Schache M, Kelly DJ, Pollock CA 2007 High glucose induces macrophage inflammatory protein-3 α in renal proximal tubule cells via a transforming growth factor-β 1 dependent mechanism. Nephrol Dial Transplant 11:3147-3153
31. Tian YC, Fraser D, Attisano L, Philips AO 2003 TGF-β 1 mediated alterations of renal proximal tubular epithelial cell phenotype. Am J Physiol 285:F130-F142
32. Humes HD, Nakamura T, Cieslinski DA, Miller D, Emmons RV, Border WA 1993 Role of proteoglycans and cytoskeleton in the effects of TGF-β 1 on renal proximal tubule cells. Kidney Int 43:575-584
33. Chambon P 1996 A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954
34. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW 1992 Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem 267:17617-17623
35. Batourina E, Choi C, Paragas N, Bello N, Hensle T, Costantini FD, Schuchardt A, Bacallao RL, Mendelsohn CL 2002 Distal ureter morphogenesis depends on epithelial cell modelling mediated by vitamin A and Ret. Nat Genet 32:109-115
36. Yang J, Dai C, Liu Y 2005 A novel mechanisms by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol 16:68-78
37. Samnegård B, Jacobson SH, Jaremko G, Johansson BL, Ekberg K, Isaksson B, Eriksson L, Wahren J, Sjöquist M 2005 C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. Nephrol Dial Transplant 20:532-538
38. Maezawa Y, Yokote K, Sonezaki K, Fujimoto M, Kobayashi K, Kawamura H, Tokuyama T, Takemoto M, Ueda S, Kuwaki T, Mori S, Wahren J, Saito Y 2006 Influence of C-peptide on early glomerular changes in diabetic mice. Diabetes Metab Res Rev 22:313-322
39. Hills CE, Bland R, Wheelans DC, Bennett J, Ronco PM, Squires PE 2006 Glucose evoked alterations in connexin-43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy. Am J Physiol 291:F1045-F1051
40. Coxon A, Rex K, Meyer S, Sun J, Sun J, Chen Q, Radinsky R, Kendall R, Burgess TL 2009 Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models. Mol Cancer Ther 8:1119-1125
41. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
42. Benjamini Y, Hochberg Y 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. JRSS 57:289-300
43. Bland R, Walker EA, Hughes SV, Stewart PM, Hewison M 1999 Constitutive expression of 25-hydroxyvitamin D3-1α-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. Endocrinology 140:2027-2034