Hydrogen peroxide induces p16INK4a through an AUF1-dependent manner

Journal of Cellular Biochemistry

Volumn 109, Issue 5, 2010, Pages 1000-1005

  Guo, Gai E ^a   Ma, Li Wei ^b   Jiang, Bin ^b   Yi, Jie ^b   Tong, Tan Jun ^b   Wang, Wen Gong ^b  

^a CHANGZHI MEDICAL COLLEGE   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

AUF1; Hydrogen peroxide; mRNA turnover; p16INK4a

Indexed keywords

CHIMERIC PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOPLASM PROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; HYDROGEN PEROXIDE; RNA;

3' UNTRANSLATED REGION; ARTICLE; CYTOPLASM; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENESCENCE;

3' UNTRANSLATED REGIONS; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN D; HUMANS; HYDROGEN PEROXIDE; PROTEIN BINDING; RNA, MESSENGER;

EID: 77950381329     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22474     Document Type: Article

References (17)

1. Burd CG, Dreyfuss G. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science 265:615-621.
2. Chen QM. 2000. Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Ann NY Acad Sci 908:111-125.
3. Chen JH, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, Hales CN. 2004. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem 279:49439-49446.
4. Frippiat C, Chen QM, Remacle J, Toussaint O. 2000. Cell cycle regulation in H(2)O(2)-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virus E6 and E7 proteins. Exp Gerontol 35:733-745.
5. Guney I, Wu S, Sedivy JM. 2006. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci USA 103:3645-3650.
6. Hiraoka W, Fuma K, Kuwabara M. 1997. Concentration-dependent modes of cell death in Chinese hamster V79 cells after treatments with H2O2. J Radiat Res (Tokyo) 38:95-102.
7. Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, van Lohuizen M, Band V, Campisi J, Dimri GP. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol 23:389-401.
8. Jackman J, Jr., Alamo I, Jr., Fornace AJ. 1994. Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes. Cancer Res 54:5656-5662.
9. Lin S, Wang W, Wilson GM, Yang X, Brewer G, Holbrook NJ, Gorospe M. 2000. Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol Cell Biol 20:7903-7913.
10. Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E. 2001. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409:1067-1070.
11. Ramirez RD, Morales CP, Herbert BS, Rohde JM, Passons C, Shay JW, Wright WE. 2001. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 15:398-403.
12. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. 2002. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109:335-346.
13. Shapiro GI, Edwards CD, Ewen ME, Rollins BJ. 1998. p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18:378-387.
14. Wang X, Martindale JL, Liu Y, Holbrook NJ. 1998. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 333(Pt 2): 291-300.
15. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M. 2000. HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol 20:760-769.
16. Wang W, Martindale JL, Yang X, Chrest FJ, Gorospe M. 2005. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep 6:158-164.
17. Wu J, Xue L, Weng M, Sun Y, Zhang Z, Wang W, Tong T. 2007. Sp1 is essential for p16 expression in human diploid fibroblasts during senescence. PLoS ONE 2:e164.