Hydrophobicity/hydrophilicity descriptors obtained from extrapolated chromatographic retention data as modeling tools for biological distribution: Application to some oxime-type acetylcholinesterase reactivators

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 508-516

  Voicu, Victor ^a,b   Sora, Iuliana ^c   Sârbu, Costel ^d   David, Victor ^e   Medvedovici, Andrei ^c,e  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b Army Center for Medical Research   (Romania)

^c Bioanalytical Laboratory   (Romania)

^d BABE BOLYAI UNIVERSITY   (Romania)

^e UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Chromatographic retention data; Descriptor correlation; Extrapolated retention; Hydrophobicity hydrophilicity descriptors; Modeling of biological partition

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1 METHYL 3 (3 OXO 1 AZA BICYCLO[2.2.2]OCTANE 1 YLMETHYOXYMETHYL) 1H IMIDAZOLE 2 CARBALDEHYDE OXIME; 2 (HYDROXYIMINOMETHYL) 1,3 DIMETHYL 3H IMIDAZOL 1 IUM; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; DIMETHYL CARBAMIC ACID 1 [2 (HYDROXYIMINOMETHYL) 3 METHYL 3H IMIDAZOL 1 YLMETHOXYMETHYL] 1 AZA BICYCLO[2.2.2]OCTANE 3 YL ESTER; ESTER DERIVATIVE; GLYCOPROTEIN; OBIDOXIME; ORGANIC SOLVENT; ORGANOPHOSPHORUS COMPOUND; OXIME; PRALIDOXIME; PYRIDINIUM DERIVATIVE; PYRIDOSTIGMINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE;

ARTICLE; BLOOD BRAIN BARRIER; CHROMATOGRAPHY; DIPOLE; DRUG PENETRATION; DRUG STRUCTURE; ELECTRICITY; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; INTOXICATION; IONIC STRENGTH; MATHEMATICAL MODEL; MOLECULAR INTERACTION; PH; PRIORITY JOURNAL; PROTEIN BINDING; TEMPERATURE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL PHENOMENA; COMPARATIVE STUDY; METABOLISM; PHYSIOLOGY; PROCEDURES; TISSUE DISTRIBUTION;

ACETYLCHOLINESTERASE; CHOLINESTERASE REACTIVATORS; CHROMATOGRAPHY; HYDROPHOBICITY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; OXIMES; TISSUE DISTRIBUTION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77950371053     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.004     Document Type: Article

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