RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

Analytical and Bioanalytical Chemistry

Volumn 391, Issue 1, 2008, Pages 367-372

  Musilek, Kamil ^a,b   Jampilek, Josef ^d   Dohnal, Jiri ^d   Jun, Daniel ^b,c   Gunn Moore, Frank ^e   Dolezal, Martin ^a   Kuca, Kamil ^b,c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d Zentiva Prague   (Czech Republic)

^e UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Acetylcholinesterase; Lipophilicity; Purity; Reactivator; RP HPLC

Indexed keywords

ACETYLCHOLINESTERASE; LIPOPHILICITY; PURITY; REACTIVATORS;

COMPUTER SOFTWARE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHANOL; STRUCTURE (COMPOSITION);

ENZYME KINETICS;

BUT 2 ENEDIOIC ACID MONO (2 ((4 (4 (2 CARBOXY 2 CYANO VINYL) PHENYLAZO) PHENYL) METHYL AMINO) ETHYL) ESTER; BUT-2-ENEDIOIC ACID MONO-(2-((4-(4-(2-CARBOXY-2-CYANO-VINYL)-PHENYLAZO)-PHENYL)-METHYL-AMINO)-ETHYL) ESTER; CHOLINESTERASE REACTIVATOR; CROSS LINKING REAGENT; LIPID; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG CONTAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; STEREOISOMERISM;

CHOLINESTERASE REACTIVATORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DRUG CONTAMINATION; LIPIDS; MOLECULAR STRUCTURE; PYRIDINIUM COMPOUNDS; STEREOISOMERISM; VINYL COMPOUNDS;

EID: 42449115631     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-008-2018-8     Document Type: Article

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