Effects of articaine and ropivacaine on calcium handling and contractility in canine ventricular myocardium

European Journal of Anaesthesiology

Volumn 27, Issue 2, 2010, Pages 153-161

  Szentandrássy, Norbert ^a   Szabó, Adrienn ^b   Almássy, János ^a   Jóna, István ^a   Horváth, Balázs ^a   Szabó, Gergely ^a   Bányász, Tamás ^a   Márton, Ildikó ^b   Nánási, Péter P ^a   Magyar, János ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Articaine; Calcium transients; Contractility; Local anaesthetics; Ropivacaine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ARTICAINE; CALCIUM; CALCIUM CHANNEL L TYPE; DYE; ROPIVACAINE; AMIDE; LOCAL ANESTHETIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL ISOLATION; CELL VACUOLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTOLE; DOG; DRUG EFFECT; ELECTROSTIMULATION; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART VENTRICLE CONTRACTILITY; INOTROPISM; NONHUMAN; PATCH CLAMP; SARCOPLASMIC RETICULUM; WHOLE CELL; ANIMAL; DOSE RESPONSE; FEMALE; HEART CONTRACTION; HEART MUSCLE; HEART VENTRICLE; MALE; METABOLISM;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARTICAINE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; SARCOPLASMIC RETICULUM;

EID: 77950355153     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e328331a37b     Document Type: Article

References (44)

1. Leone S, Di Cianni S, Casati A, Fanelli G. Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed 2008; 79:92-105.
2. Ortel R, Rahn R, Kirch W. Clinical Pharmacokinetics of articaine. Clin Pharmacokinet 1997; 33:417-425.
3. Groban L, Deal DD, Vernon JC, et al. Does local anesthetic stereoselectivity or structure predict myocardial depression in anesthetized canines? Reg Anesth Pain Med 2002; 27:460-468.
4. Bilir A, Yelken B, Kaygisiz Z, Senturk Y. The effects of dopexamine in bupivacaine and ropivacaine induced cardiotoxicity in isolated rat heart. Saudi Med J 2006; 27:1194-1198.
5. Pitkanen M, Feldman HS, Arthur GR, Covino BG. Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrical paced isolated, perfused rabbit heart. Reg Anesth 1992; 17:183-192.
6. Royse CF, Royse AG. The myocardial and vascular effects of bupivacaine, levobupivacaine, and ropivacaine using pressure volume loops. Anesth Analg 2005; 101:679-687.
7. Groban L, Deal DD, Vernon JC, et al. Cardiac resuscitation after incremental overdose with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 2001; 92:37-43.
8. Chang DHT, Ladd LA, Copeland S, et al. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine, and ropivacaine in the sheep. Br J Pharmacol 2001; 132:649-658.
9. Graf BM. The cardiotoxicity of local anesthetics: The place of ropivacaine. Curr Top Med Chem 2001; 1:207-214.
10. Polley LS, Santos AC. Cardiac arrest following regional anesthesia with ropivacaine: Here we go again! Anesthesiology 2003; 99:1253-1254.
11. Huet O, Eyrolle LJ, Mazoit JX, Ozier YM. Cardiac arrest after injection of ropivacaine for posterior lumbar plexus blockade. Anesthesiology 2003; 99:1451-1453.
12. Reinikainen M, Hedman A, Pelkonen O, Ruokonen E. Cardiac arrest after interscalene brachial plexus block with ropivacaine and lidocaine. Acta Anaesthesiol Scand 2003; 47:904-906.
13. Porter JM, Markos F, Snow HM, Shorten GD. The efficacy of nicorandil, calcium chloride and nitroglycerin in treatment of ropivacaine-induced cardiotoxicity. Eur J Anaesth 2003; 20:939-944.
14. Lefrant JY, de La Coussaye JE, Ripart J, et al. The comparative electrophysiologic and hemodynamic effects of a large dose of ropivacaine and bupivacaine in anesthetized and ventilated piglets. Anesth Analg 2001; 93:1598-1605.
15. Stehr SN, Christ T, Rasche B, et al. The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations. Anesth Analg 2007; 105:641-647.
16. Graf BM, Abraham I, Eberbach N, et al. Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physiochemical and stereoselective properties. Anesthesiology 2002; 96:1427-1434.
17. David JS, Ferreti C, Amour J, et al. Effects of bupivacaine, levobupivacaine and ropivacaine on myocardial relaxation. Can J Anaesth 2007; 54:208-217.
18. Mio Y, Fukuda N, Kusakari Y, et al. Comparative effects of bupivacaine and ropivacaine on intracellular calcium transients and tension in ferret ventricular muscle. Anesthesiology 2004; 101:888-894.
19. Szabó A, Szentandrássy N, Birinyi P, et al. Effects of articaine on action potential characteristics and the underlying ion currents in canine ventricular myocytes. Br J Anaesth 2007; 99:726-733.
20. Szabó A, Szentandrá ssy N, Birinyi P, et al. Effects of ropivacaine on action potential configuration and ion currents in isolated canine ventricular cardiomyocytes. Anesthesiology 2008; 108:693-702.
21. Szentandrássy N, Bányász T, Bíró T, et al. Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium. Cardiovasc Res 2005; 65:851-860.
22. Szabó G, Szentandrássy N, Bíró T, et al. Asymmetrical distribution of ion channels in canine and human left ventricular wall: Epicardium versus midmyocardium. Pfluögers Arch 2005; 450:307-316.
23. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with a greatly improved fluorescence properties. J Biol Chem 1985; 260:3440-3450.
24. Hamill OP, Marty A, Neher E, et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluögers Arch 1981; 391:85-100.
25. Lai FA, Meissner G. Structure of the calcium release channel of skeletal muscle sarcoplasmic reticulum and its regulation by calcium. Adv Exp Med Biol 1990; 269:73-77.
26. Sarkozi S, Szegedi C, Lukacs B, et al. Effect of gadolinium on the ryanodine receptor/sarcoplasmic reticulum calcium release channel of skeletal muscle. FEBS J 2005; 272:464-471.
27. 2+ currents in single canine ventricular cells. Masui 1995; 44:193-199.
28. Hatakeyama N, Yamada M, Shibuya N, et al. Effects of ropivacaine on membrane potential and voltage-dependent calcium channel current in single guinea-pig ventricular myocytes. J Anesth 2002; 16:273-278.
29. Ding HL, Zeng YM, Li XD, et al. Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes. Acta Pharmacol Sin 2002; 23:50-54.
30. Moller RA, Covino BG. Cardiac electrophysiologic effects of articaine compared with bupivacaine and lidocaine. Anesth Analg 1993; 76:1266-1273.
31. Arlock P. Actions of three local anaesthetics: Lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (Vmax). Pharmacol Toxicol 1988; 63:96-104.
32. Moller R, Covino BG. Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology 1990; 72:322-329.
33. Bers DM. Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res 2000; 87:275-281.
34. Karon BS, Geddis LM, Kutchai H, Thomas DD. Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulum. Biophys J 1995; 68:936-945.
35. Tinker A, Williams AJ. Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophys J 1993; 65:852-864. (Pubitemid 23263896)
36. 2+ release channel of skeletal and cardiac muscle. Anesthesiology 1999; 90:835-843.
37. Chedid NGB, Sudo RT, Aguiar MIS, et al. Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats. Anesth Analg 2005; 102:792-798.
38. Hersh EV, Giannakopoulos H, Levin LM, et al. The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine. J Am Dent Assoc 2006; 137:1562-1571.
39. Muller WP, Weiser P, Scholler KL. Pharmacokinetics of articaine in mandibular nerve block. Reg Anaesth 1991; 14:52-55.
40. Wulf H, Worthmann F, Behnke H, Bohle AS. Pharmacokinetics and pharmacodynamics of ropivacaine 2 mg/ml, 5 mg/ml, or 7.5 mg/ml after ilioinguinal blockade for inguinal hernia repair in adults. Anesth Analg 1999; 89:1471-1474.
41. Costello TG, Cromack JR, Hoy C, et al. Plasma ropivacaine levels following scalp block for awake craniotomy. J Neurosurg Anesth 2004; 16:147-150.
42. -1 for i.v. regional anesthesia in outpatient surgery. Br J Anaesth 2006; 96:640-644.
43. Salonen MH, Haasio J, Bachmann M, et al. Evaluation of efficacy and plasma concentrations of ropivacaine in continuous axillary brachial plexus block: High dose for surgical anesthesia and low dose for postoperative analgesia. Reg Anesth Pain Med 2000; 25:47-51.
44. Burm AG, Stienstra R, Brouwer RP, et al. Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery: Pharmacokinetic evaluation. Anesthesiology 2000; 93:395-403.