The efficacy of nicorandil, calcium chloride and nitroglycerin in treatment of ropivacaine-induced cardiotoxicity

European Journal of Anaesthesiology

Volumn 20, Issue 12, 2003, Pages 939-944

  Porter, J M ^a,c   Markos, F ^b   Snow, H M ^b   Shorten, G D ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b Department of Physiology ^*  (Ireland)

^c Mullingar Co Westmeath   (Ireland)

Author keywords

Anaesthetics, local, ropivacaine; DOGS; Drug Toxicity, ropivacaine; Heart, myocardium; Myocardial Contractility

Indexed keywords

CALCIUM CHLORIDE; GLYCERYL TRINITRATE; NICORANDIL; PENTOBARBITAL; ROPIVACAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED DISEASE; FEMALE; FISHER EXACT TEST; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE; MALE; NONHUMAN; THORACOTOMY;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CALCIUM CHLORIDE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMIC PROCESSES; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; MALE; MYOCARDIAL CONTRACTION; NICORANDIL; NITROGLYCERIN; TREATMENT OUTCOME; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 0345491334     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021503001510     Document Type: Article

References (20)

1. Albright GA. Cardiac arrest following regional anaesthesia with etidocaine or bupivacaine. Anesthesiology 1979; 51: 285-287.
2. Reiz S, Haggmark G, Nath S. Cardiotoxicity of ropivacaine -a new amide local anaesthetic agent. Acta Anaesthesiol Scand 1989; 33: 93-98.
3. De Jong RH, Davis NL. Treating bupivacaine arrhythmias: preliminary report. Reg Anesth 1981; 6: 99-103.
4. Kotelko DM, Shnider SM, Dailey PA, et al. Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology 1984; 60: 10-18.
5. Moller R, Covino GG. Cardiac electrophysiological properties of bupivacaine and lidocaine compared to those of ropivacaine, a new amide local anesthetic. Anesthesiology 1990; 72: 322-329.
6. Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 1985; 62: 392-405.
7. De La Cousaye JE, Masse C, Bassoul BP, Eledjam JJ, Gagnol JP, Sasine A. Bupivacaine-induced slow-inward current inhibition: a voltage clamp study on frog atrial fibres. Can J Anaesth 1990; 37: 819-822.
8. Porter JM, Markos F, Snow HM, Shorten GD. Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs. Br J Anaesth 2000; 84: 92-94.
9. + current but not the inward rectifier in rat myocytes. J Pharmacol Exper Therap 1990; 255: 1038-1046.
10. Courtney KR, Kendig JJ. Bupivacaine is an effective potassium channel blocker in the heart. Biochim Biophys Acta 1988; 939: 163-166.
11. Sanchez-Chapula J. Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes. Eur J Pharmacol 1988; 156: 303-308.
12. Eledjam JJ, de La Coussaye JE, Brugada J, et al. In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility. Anesth Analg 1989; 69: 732-735.
13. Gherardini G, Samuelson U, Jernbeck J, Aberg, Sjostrand N. Comparison of vascular effects of ropivacaine and lidocaine on isolated rings of human arteries. Acta Anaesthesiol Scand 1995; 39: 765-768.
14. Saitoh K, Hirabayashi Y, Shimizu R, Fukuda H. Amrinone is superior to epinephrine in reversing bupivacaine-induced cardiovascular depression in sevoflurane-anesthetized dogs. Anesthesiology 1995; 83: 127-133.
15. De La Coussaye JE, Eledjam JJ, Peray P, et al. Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. Anesthesiology 1994; 80: 595-605.
16. Kasten GW, Martin ST. Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs. Anesth Analg 1985; 64: 491-497.
17. De La Coussaye, Eledjam JJ, Peray P, et al. Lemakalim, a potassium channel agonist, reverses electrophysiological impairments induced by a large dose of bupivacaine in anaesthetized dogs. Br J Anaesth 1993; 71: 534-539.
18. Purcell H, Mulcahy D, Fox K. The clinical profile of nicorandil. Rev Contemp Pharmacother 1993; 4: 215-220.
19. Surtapranata H, MacLeod D. Nicorandil and cardiovascular performance in patients with coronary artery disease. J Cardiovasc Pharmacol 1992; 20: S45-S51.
20. Tanz RD, Heskett T, Loehning RW, Fairfax CA. Comparative cardiotoxicity of bupivacaine and lidocaine in the isolated perfused mammalian heart. Anesth Analg 1984; 63: 549-556.