The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease

Neuroscience Letters

Volumn 473, Issue 3, 2010, Pages 248-251

  Coppedè, Fabio ^a   Ceravolo, Roberto ^a   Migheli, Francesca ^a   Fanucchi, Francesca ^a   Frosini, Daniela ^a   Siciliano, Gabriele ^a   Bonuccelli, Ubaldo ^a   Migliore, Lucia ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

8 oxo G; DNA repair; HOGG1 Ser326Cys polymorphism; OGG1; Oxidative DNA damage; Parkinson's disease (PD)

Indexed keywords

CYSTINE; DNA GLYCOSYLTRANSFERASE; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; MUTANT PROTEIN; OXOGUANINE DNA GLYCOSYLASE; SERINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPROTECTION; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN VARIANT; SUBSTANTIA NIGRA; UPREGULATION;

AGE OF ONSET; DNA GLYCOSYLASES; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PARKINSON DISEASE; POLYMORPHISM, GENETIC;

EID: 77950339885     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.02.059     Document Type: Article

References (32)

1. Arai T., Fukae J., Hatano T., Kubo S., Ohtsubo T., Nakabeppu Y., Mori H., Mizuno Y., Hattori N. Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol. 2006, 112:139-145.
2. Bravard A., Vacher M., Moritz E., Vaslin L., Hall J., Epe B., Radicella J.P. Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity. Cancer Res. 2009, 69:3642-3649.
3. Cardozo-Pelaez F., Cox D.P., Bolin C. Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development. Gene Exp. 2005, 12:315-323.
4. Coppedè F., Armani C., Bidia D.D., Petrozzi L., Bonuccelli U., Migliore L. Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. Mutat. Res. 2005, 579:107-114.
5. Coppedè F., Mancuso M., Lo Gerfo A., Carlesi C., Piazza S., Rocchi A., Petrozzi L., Nesti C., Micheli D., Bacci A., Migliore L., Murri L., Siciliano G. Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis. Neurosci. Lett. 2007, 420:163-168.
6. Coppedè F., Mancuso M., Lo Gerfo A., Manca M.L., Petrozzi L., Migliore L., Siciliano G., Murri L. A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. Neurosci. Lett. 2007, 414:282-285.
7. F. Coppedè, F. Migheli, R. Ceravolo, E. Bregant, A. Rocchi, L. Petrozzi, E. Unti, R. Lonigro, G. Siciliano, L. Migliore, The hOGG1 Ser326Cys polymorphism and Huntington's disease, Toxicology, in press.
8. Coppedè F., Migliore L. DNA repair in premature aging disorders and neurodegeneration. Curr. Aging Sci. 2010, 3:3-19.
9. Fukae J., Mizuno Y., Hattori N. Mitochondrial dysfunction in Parkinson's disease. Mitochondrion 2007, 7:58-62.
10. Fukae J., Takanashi M., Kubo S., Nishioka K., Nakabeppu Y., Mori H., Mizuno Y., Hattori N. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta Neuropathol. 2005, 109:256-262.
11. Hill J.W., Hu J.J., Evans M.K. OGG1 is degraded by calpain following oxidative stress and cisplatin exposure. DNA Repair (Amst) 2008, 7:648-654.
12. Hohen M.M., Yahr M.D. Parkinsonism: onset, progression and mortality. Neurology 1967, 17:427-442.
13. Hughes T.A., Ross H.F., Musa S., Bhattacherjee S., Nathan R.N., Mindham R.H., Spokes E.G. A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease. Neurology 2000, 54:1596-1602.
14. Jarem D.A., Wilson N.R., Delaney S. Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry 2009, 48:6655-6663.
15. Kikuchi H., Furuta A., Nishioka K., Suzuki S.O., Nakabeppu Y., Iwaki T. Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol. (Berl.) 2002, 103:408-414.
16. Kovtun I.V., Liu Y., Bjoras M., Klungland A., Wilson S.H., McMurray C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 2007, 447:447-452.
17. Lovell M.A., Xie C., Markesbery W.R. Decreased base excision repair and increased helicase activity in Alzheimer's disease brain. Brain Res. 2000, 855:116-123.
18. Martin H.L., Teismann P. Glutathione-a review on its role and significance in Parkinson's disease. FASEB J. 2009, 23:3263-3272.
19. Migliore L., Coppedè F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat. Res. 2009, 667:82-97.
20. Migliore L., Scarpato R., Coppedè F., Petrozzi L., Bonuccelli U., Rodilla V. Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients. Int. J. Hyg. Environ. Health 2001, 204:61-66.
21. Okasaka T., Matsuo K., Suzuki T., Ito H., Hosono S., Kawase T., Watanabe M., Yatabe Y., Hida T., Mitsudomi T., Tanaka H., Yokoi K., Tajima K. hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type. J. Hum. Genet. 2009, 54:739-745.
22. Parildar-Karpuzoĝlu H., Doĝru-Abbasoĝlu S., Hanagasi H.A., Karadaĝ B., Gürvit H., Emre M., Uysal M. Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease. Neurosci. Lett. 2008, 442:287-291.
23. Romanowicz-Makowska H., Smolarz B., Makowski K., Połać I., Pertyński T. Ser326Cys polymorphism in DNA repair genes hOGG1 in breast cancer women. Pol. J. Pathol. 2008, 59:201-204.
24. Rothfuss O., Fischer H., Hasegawa T., Maisel M., Leitner P., Miesel F., Sharma M., Bornemann A., Berg D., Gasser T., Patenge N. Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair. Hum. Mol. Genet. 2009, 18:3832-3850.
25. Shao C., Xiong S., Li G.M., Gu L., Mao G., Markesbery W.R., Lovell M.A. Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic. Biol. Med. 2008, 45:813-819.
26. Shimura-Miura H., Hattori N., Kang D., Miyako K., Nakabeppu Y., Mizuno Y. Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease. Ann. Neurol. 1999, 46:920-924.
27. Sugimura H., Kohno T., Wakai K., Nagura K., Genka K., Igarashi H., Morris B.J., Baba S., Ohno Y., Gao C., Li Z., Wang J., Takezaki T., Tajima K., Varga T., Sawaguchi T., Lum J.K., Martinson J.J., Tsugane S., Iwamasa T., Shinmura K., Yokota J. hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 1999, 8:669-674.
28. Thomas B., Beal M.F. Parkinson's disease. Hum. Mol. Genet. 2007, 16:R183-R194.
29. Wikman H., Risch A., Klimek F., Schmezer P., Spiegelhalder B., Dienemann H., Kayser K., Schulz V., Drings P., Bartsch H. hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a Caucasian population. Int. J. Cancer 2000, 88:932-937.
30. Wong A.W., McCallum G.P., Jeng W., Wells P.G. Oxoguanine glycosylase 1 protects against methamphetamine-enhanced fetal brain oxidative DNA damage and neurodevelopmental deficits. J. Neurosci. 2008, 28:9047-9054.
31. Yamaguchi H., Kajitani K., Dan Y., Furuichi M., Ohno M., Sakumi K., Kang D., Nakabeppu Y. MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Cell Death Differ. 2006, 13:551-563.
32. J. Zhang, I.B. Dhakal, G. Greene, N.P. Lang, F.F. Kadlubar, Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants, Urology, in press.