Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 4, 2010, Pages

  Toby, Inimary T ^a   Chicoine, Louis G ^a   Cui, Hongmei ^a   Chen, Bernadette ^a   Nelin, Leif D ^a  

^a NONE

Author keywords

L arginine; Pulmonary hypertension; Vascular remodeling

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ARGINASE; ARGINASE 1; ARGINASE II; BETA ACTIN; CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UREA;

ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ARGINASE; CELL HYPOXIA; CELL PROLIFERATION; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION; HUMANS; LUNG; MICROVESSELS; MODELS, BIOLOGICAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TYRPHOSTINS; UREA;

EID: 77950335263     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00122.2009     Document Type: Article

References (27)

1. Albina J, Mahoney E, Daley J, Reichner JS. Macrophage arginase regulation by CCAAT/enhancer-binding protein β. Shock 23: 168-172, 2005.
2. Bachetti T, Comini L, Francolini G, Bastianon D, Valetti B, Cadei M, Grigolato P, Ferrari R. Arginase pathway in human endothelial cells in pathophysiological conditions. J Mol Cell Cardiol 37: 515-523, 2004.
3. Baldwin BR, Timchenko NA, Zahnow CA. Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPβ-LIP in mammary epithelial cells. Mol Cell Biol 24: 3682-3691, 2004.
4. Banks M, Gerasimovskaya E, Tucker D, Stenmark K. Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. J Appl Physiol 98: 732-738, 2005.
5. Bivalacqua TJ, Burnett AL, Hellstrom WJ, Champion HC. Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of antiarginase. Am J Physiol Heart Circ Physiol 292: H1340-H1351, 2007.
6. Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity. Am J Physiol Lung Cell Mol Physiol 295: L688-L697, 2008.
7. Chen K, Vita JA, Berk BC, Keaney JF. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem 276: 16045-16050, 2001.
8. Chicoine LG, Paffett ML, Young TL, Nelin LD. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 287: L60-L68, 2004.
9. Chowdhury S, Gotoh T, Mori M, Takiguchi M. CCAAT/enhancerbinding protein β binds and activates while hepatocyte nuclear factor-4 does not bind but represses the liver-type arginase promoter. Eur J Biochem 236: 500-509, 1996.
10. DeLuca A, Carotenuto A, Rachiglio A, Gallo M, Normanno N. The role of the EGFR signaling in tumor microenvironment. J Cell Physiol 214: 559-567, 2007.
11. Franovic A, Gunaratnam L, Smith K, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci USA 104: 13092-13097, 2007.
12. Gray MJ, Poljakovic M, Kepka-Lenhart D, Morris SM Jr. Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. Gene 353: 98-106, 2005.
13. He D, Natarajan V, Stern R, Gorshkova IA, Solway J, Spannhake EW, Zhao Y. Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase 2 expression and prostaglandin E2 release via C/EBPβ in human bronchial epithelial cells. Biochem J 412: 153-162, 2008.
14. Ignarro LJ, Buga GM, Wei LH, Bauer PM, Wu G, del Soldato P. Role of the arginine-nitric oxide pathway in the regulation of smooth muscle cell proliferation. Proc Natl Acad Sci USA 98: 4202-4208, 2001.
15. Koga T, Koshiyama Y, Gotoh T, Yonemura N, Hirata A, Tanihara H, Negi A, Mori M. Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. Exp Eye Res 75: 659-667, 2002.
16. Li H, Meininger CJ, Kelly KA, Hawker JR, Morris SM, Wu G. Activities of arginase I and II are limiting for endothelial cell proliferation. Am J Physiol Regul Integr Comp Physiol 282: R64-R69, 2002.
17. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real time quantitative PCR and the 2[-ΔΔC(t)] method. Methods 25: 402-408, 2001.
18. Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. J Biol Chem 281: 32197-32206, 2006.
19. Nelin LD, Nash HE, Chicoine LG. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 281: L1232-L1239, 2001.
20. Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor. Am J Respir Cell Mol Biol 33: 394-401, 2005.
21. Nelin LD, Stenger MR, Malleske DT, Chicoine LG. Vascular arginase and hypertension. Curr Hypertens Rev 3: 242-249, 2007.
22. Pauleau AL, Rutschman R, Lang R, Pernis A, Watowich SS, Murray PJ. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol 172: 7565-7573, 2004.
23. Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YT. Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol Lung Cell Mol Physiol 275: L96-L102, 1998.
24. Salimuddin Nagasaki A, Gotoh T, Isobe H, Mori M. Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide. Am J Physiol Endocrinol Metab 277: E110-E117, 1999.
25. Schearer JD, Richards JR, Mills JD, Caldwell MD. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol Endocrinol Metab 272: E181-E190, 1997.
26. Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin LD. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 290: L298-L306, 2006.
27. Wei LH, Wu G, Morris SM, Ignarro LJ. Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci USA 98: 9260-9264, 2001.