Overexpression of Smad6 exacerbates pancreatic fibrosis in murine caerulein-induced chronic pancreatic injuries

Pancreas

Volumn 39, Issue 3, 2010, Pages 385-391

  Miyamoto, Tamao ^a   Nakamura, Hayato ^a   Nagashio, Yoshikuni ^a   Asaumi, Hiroshi ^a   Harada, Masaru ^a   Otsuki, Makoto ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Bone morphogenic proteins; Pancreatic fibrosis; Pancreatic stellate cells; Smad6; Transforming growth factor A1; Transgenic mice

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CERULETIDE; HYDROXYPROLINE; MESSENGER RNA; SMAD6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRYPSIN;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE EXACERBATION; ENZYME ACTIVITY; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE;

ANIMALS; CAERULEIN; DISEASE PROGRESSION; FIBROSIS; MALE; MICE; MICE, TRANSGENIC; PANCREATITIS, CHRONIC; SMAD6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN;

EID: 77950294655     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181bb9603     Document Type: Article

References (38)

1. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signaling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390: 465-471.
2. Miyazono K, Kusanagi K, Inoue H. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol. 2001;187:265-276.
3. Miyazono K. Positive and negative regulation of TGF-beta signaling. J Cell Sci. 2000;113:1101-1109.
4. Hanyu A, Ishidou Y, Ebisawa T, et al. The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling. J Cell Biol. 2001;155:1017-1027.
5. Hata A, Lagna G, Massague J, et al. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998;12:186-197.
6. Ishisaki A, Yamamoto K, Hashimoto S, et al. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem. 1999;274:13637-13642.
7. Mochizuki T, Miyazaki H, Hara T, et al. Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem. 2004;279:31568-31574.
8. Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol. 1990;6:597-641.
9. Broekelmann TJ, Limper AH, Colby TV, et al. Transforming growth factor A1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci U S A. 1991;88: 6642-6646.
10. Sporn MB, Roberts AB. Transforming growth factor-b: recent progress and new challenges. J Cell Biol. 1992;119:1017-1021.
11. Yoshioka K, Takemura T, Murakami K, et al. Transforming growth factor-A protein and mRNA in glomeruli in normal and diseased human kidneys. Lab Invest. 1993;68:154-163.
12. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 1993;328:1828-1835.
13. Border WA, Noble NA. Transforming growth factor A in tissue fibrosis. N Engl J Med. 1994;331:1286-1292.
14. Li RK, Li G, Mickle DAG, et al. Overexpression of transforming growth factor-A1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation. 1997;96:874-881.
15. Jadrich JL, O'Connor MB, Coucouvanis E. Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development. Gene Expr Patterns. 2003;3:131-134.
16. Jiang FX, Stanley EG, Gonez LJ, et al. Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J Cell Sci. 2002;115:753-760.
17. Tiso N, Filippi A, Pauls S, et al. BMP signaling regulates anteroposterior endoderm patterning in zebrafish. Mech Dev. 2002;118:29-37.
18. Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003;9:964-968.
19. Zeisberg M. Bone morphogenic protein-7 and the kidney: current concepts and open questions. Nephrol Dial Transplant. 2006;21: 568-573.
20. Wang S, de Caestecker M, Kopp J, et al. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol. 2006;17:2504-2512.
21. Shannon JM, Hyatt BA. Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol. 2004;66:625-645.
22. Wang S, Hirschberg R. BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol. 2003; 284:F1006YF1013.
23. Nakamura H, Tashiro M, Asaumi H, et al. Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models. Gut. 2008;57:788-798.
24. Neuschwander-Tetri BA, Bridle KR, Wells LD, et al. Repetitive acute pancreatic injury in the mouse induces procollagen >1(I) expression colocalized to pancreatic stellate cells. Lab Invest. 2000;80:143-150.
25. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43: 128-133.
26. Schneider E, Schmid-Kotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol Cell Physiol. 2001;281: C532YC543.
27. Yoshikawa H, Kihara Y, Taguchi M, et al. Role of TGF-A1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima fatty rats. Am J Physiol Gastrointest Liver Physiol. 2002;282: G549YG558.
28. Woessner JFJ. The determination of hydroxyproline in tissue and protein samples containing small amounts of the amino acid. Arch Biochem Biophys. 1961;93:440-447.
29. Saluja AK, Bhaga L, Lee HS, et al. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 1999;276:G835YG842.
30. Klöppel G, Maillet B. The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis. Virchows Arch A Pathol Anat Histopathol. 1992;420:1-4.
31. Detlefsen S, Sipos B, Feyerabend B, et al. Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokines. Mod Pathol. 2006;19:1019-1026.
32. Bachem MG, Schneider E, Gross H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421-432.
33. Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 1999;44:534-541.
34. Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol. 1999;155:1087-1095.
35. Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 2002;50:535-541.
36. Casini A, Galli A, Pignalosa P, et al. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) colocalizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis. J Pathol. 2000;192:81-89.
37. Friess H, Cantero D, Graber H, et al. Enhanced urokinase plasminogen activation in chronic pancreatitis suggests a role in its pathogenesis. Gastroenterology. 1997;113:904-913.
38. Van Laethem JL, Deviere J, Resibois A, et al. Localization of transforming growth factor beta1 and its latent binding protein in human chronic pancreatitis. Gastroenterology. 1995;108:1873-1881.