Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models

Gut

Volumn 57, Issue 6, 2008, Pages 788-798

  Nakamura, Hayato ^a   Tashiro, M ^a   Asaumi, H ^a   Nomiyama, Y ^a   Kaku, M ^a   Watanabe, S ^a   Miyamoto, T ^a   Otsuki, M ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CALCIUM ION; CERULETIDE; CHOLECYSTOKININ OCTAPEPTIDE; ETHIONINE; SMAD6 PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ACINAR CELL; ACUTE PANCREATITIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CODING; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET; ELASTASE 1 GENE; ENHANCER REGION; ENZYME ACTIVITY; ENZYME RELEASE; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ORGAN WEIGHT; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STIMULATION; TRANSGENIC MOUSE; WILD TYPE;

ACUTE DISEASE; AMINO ACID SEQUENCE; AMYLASES; ANIMALS; CAERULEIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PANCREAS, EXOCRINE; PANCREATITIS; PHENOTYPE; RNA, MESSENGER; SEQUENCE ALIGNMENT; SMAD6 PROTEIN; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 44149108489     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.119370     Document Type: Article

References (45)

1. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001;2:117-29.
2. Sporn MB, Boberts AB. TGF-beta: problems and prospects. Cell Regul 1990;12:875-82.
3. Watanabe M, Whitman M. The role of transcription factors involved in TGF beta superfamily signaling during development. Cell Mol Biol 1999;45:537-43.
4. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-71.
5. Miyazono K, Kusanagi K, Inoue H. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 2001;187:265-76.
6. Miyazono K. Positive and negative regulation of TGF-beta signaling. J Cell Sci 2000;113:1101-9.
7. Imamura T, Takase M, Nishihara A, et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 1997;389:622-6.
8. Nakao A, Miike S, Hatano M, et al. Blockade of transforming growth factor beta/ Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 2000;192:151-8.
9. Horiki M, Imamura T, Okamoto M, et al. Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol 2004;165:433-45.
10. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
11. Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 1996;120:284-8.
12. Richards GM. Modifications of the diphenylamine reaction giving increased sensitivity and simplicity in the estimation of DNA. Anal Biochem 1974;57:369-76.
13. Ceska M, Birath K, Brown BA. New and rapid method for the clinical determination of α-amylase activities in human serum and urine. Optimal conditions. Clin Chim Acta 1969;26:437-44.
14. Watanabe S, Nagashio Y, Asaumi H, et al. Pressure activates rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004;287:G1175-81.
15. Korc M, Chandrasekar B, Yamanaka Y, et al. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 1992;90:1352-60.
16. Bhatia M, Brady M, Zagorski J, et al. Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury. Gut 2000;47:838-44.
17. Nakamura H, Tashiro M, Yamaguchi T, et al. Preferential increase of extracellular matrix expression relative to TGF-β1 in the pancreas during the early stage of acute hemorrhagic pancreatitis in rats. Pancreas 2007;35:e23-9.
18. Otsuki M, Williams JA. Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini. J Clin Invest 1982;70:148-56.
19. 2+ release in pancreatic acinar cells. J Biol Chem 1997;272:31435-40.
20. Saluja AK, Bhagat L, Lee HS, et al. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol 1999;276:G835-42.
21. Schafer C, Ross SE, Bragado MJ, et al. A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini. J Biol Chem 1998;273:24173-80.
22. Riesle E, Friess H, Zhao L, et al. Increased expression of transforming growth factor βs after acute oedematous pancreatitis in rats suggests a role in pancreatic repair. Gut 1997;40:73-9.
23. Vaquero E, Molero X, Tian X, et al. Myofibroblast proliferation, fibrosis, and defective pancreatic repair induced by cyclosporin in rats. Gut 1999;45:269-77.
24. Hahm KB, Im YH, Lee C, et al. Loss of TGF-beta signaling contributes to autoimmune pancreatitis. J Clin Invest 2000;105:1057-65
25. Lombardi D, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline deficient diet. Am J Pathol 1975;79:465-80.
26. Niederau C, Luthen R, Niedema MC, et al. Acute experimental hemorrhagic-necrotizing pancreatitis induced by feeding a choline-deficient, ethionine-supplemented diet. Eur Surg Res 1992;24(Suppl 1):40-54.
27. Burnham DB, Williams JA. Effects of high concentrations of secretagogues on the morphology and secretory activity of the pancreas: a role for microfilaments. Cell Tissue Res 1982;222:201-12.
28. O'Konski MS, Pandol SJ. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell. J Clin Invest 1990;86:1649-57.
29. O'Konski MS, Pandol SJ. Cholecystokinin JMV-180 and caerulein effects on the pancreatic acinar cell cytoskeleton. Pancreas 1993;8:638-46.
30. Bi Y, Page SL, Williams JA. Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol Gastrointest Liver Physiol 2005;289:G561-70.
31. 2+-dependent synaptotagmin isoforms in mouse and rat parotid acinar cells. Yonsei Med J 2006;47:70-7.
32. Jadrich L, O'Connor MB, Coucouvanis E. Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development. Gene Expr Patterns 2003;3:131-4.
33. Jiang FX, Stanley EG, Gonez LJ, et al. Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J Cell Sci 2002;115:753-60.
34. Tiso N, Filippi A, Pauls S, et al. BMP signalling regulates anteroposterior endoderm patterning in zebrafish. Mech Dev 2002;118:29-37.
35. Fukayama M, Ogawa M, Hayashi Y, et al. Development of human pancreas. Immunohistochemical study of fetal pancreatic secretory proteins. Differentiation 1986;31:127-33.
36. Lee MS, Gu D, Feng L, et al. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1. Am J Pathol 1995;147:42-52.
37. Nagashio Y, Ueno H, Imamura M, et al. Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. Lab Invest 2004;84:1610- 8.
38. Wildi S, Kleeff J, Mayerle J, et al. Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations. Gut 2007;56:685-92.
39. Gaisano HY, Sheu L, Foskett JK, et al. Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. J Biol Chem 1994;269:17062-6.
40. Hansen NJ, Antoninm W, Edwardson JM. Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cell. J Biol Chem 1999;274:22871-6.
41. Ohnishi H, Mine T, Shibata H, et al. Involvement of Rab4 in regulated exocytosis of rat pancreatic acini. Gastroenterology 1999;116:943-52.
42. Ohnishi H, Samuelson LC, Yule DI, et al. Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice. J Clin Invest 1997;100:3044-52.
43. Valentijn JA, Gien LT, Valentijn KM, et al. An evaluation of the expression, subcellular localization, and function of rab4 in the exocrine pancreas. Biochem Biophys Res Commun 2000;268:847-52.
44. Jensen RT, Gardner JD. Cyclic nucleotide-dependent protein kinase activity in acinar cells from guinea pig pancreas. Gastroenterology 1978;75:806-16.
45. Watanabe O, Baccino FM, Steer ML, et al. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol 1984;246(4, Pt 1):G457-67.