Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation

British Journal of Pharmacology

Volumn 159, Issue 8, 2010, Pages 1608-1622

  Makwana, R ^a   Molleman, A ^b   Parsons, Me ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

Cannabinoid; Cannabinoid receptor agonists; Cannabinoid receptor antagonist inverse agonist; Contractions; Ileum; Myenteric plexus longitudinal muscle; Rimonabant; Small intestine

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ACETYLCHOLINE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CAPSAZEPINE; DRONABINOL; RIMONABANT;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ELECTROSTIMULATION; ENZYME ACTIVATION; ILEUM; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARACHIDONIC ACIDS; BENZOXAZINES; CYCLOHEXANOLS; ELECTRIC STIMULATION; FEMALE; ILEUM; MALE; MORPHOLINES; MYENTERIC PLEXUS; NAPHTHALENES; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; TETRAHYDROCANNABINOL;

EID: 77950291186     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00592.x     Document Type: Article

References (62)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels, 3rd edn. Br J Pharmacol 153 : S1 S209.
2. Anavi-Goffer S, McKay NG, Ashford ML, Coutts AA (2002). Vanilloid receptor type 1-immunoreactivity is expressed by intrinsic afferent neurones in the guinea-pig myenteric plexus. Neurosci Lett 319 : 53 57.
3. Arunlakshana O, Schild HO (1959). Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 14 : 48 58.
4. Baker D, Pryce G, Davies WL, Hiley CR (2006). In silico patent searching reveals a new cannabinoid receptor. Trends Pharmacol Sci 27 : 1 4.
5. Barlow RB, Bond SM, Grant C, McQueen DS, Yaqoob Z (2001a). A comparison of effects measured with isotonic and isometric recording: I. Concentration-effect curves for agonists. Br J Pharmacol 133 : 1081 1086.
6. Barlow RB, Bond SM, Grant C, McQueen DS, Yaqoob Z (2001b). A comparison of effects measured with isotonic and isometric recording: II. Concentration-effect curves for physiological antagonists. Br J Pharmacol 133 : 1087 1095.
7. Begg M, Dale N, Llaudet E, Molleman A, Parsons ME (2002a). Modulation of the release of endogenous adenosine by cannabinoids in the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol 137 : 1298 1304.
8. Begg M, Molleman A, Parsons ME (2002b). Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum. Eur J Pharmacol 434 : 87 94.
9. Borelli F, Capasso R, Pinto A, Izzo AA (2004). Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro. Life Sci 74 : 2889 2896.
10. Brown AJ (2007). Novel cannabinoid receptors. Br J Pharmacol 152 : 567 575.
11. 1 and opioid receptors in gastrointestinal motility in mice. Br J Pharmacol 148 : 1043 1050.
12. Chakrabarti A, Onaivi ES, Chaudhuri G (1995). Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein. DNA Seq 5 : 385 388.
13. Colombo G, Agabio R, Lobina C, Reali R, Gessa GL (1998). Cannabinoid modulation of intestinal propulsion in mice. Eur J Pharmacol 344 : 67 69.
14. Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogues: cannabimimetic activity of a class of compounds structurally distinct from delta-9-tetrahydrocannabinol. J Pharmacol Exp Ther 263 : 1118 1126.
15. Coutts AA, Pertwee RG (1997). Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus. Br J Pharmacol 121 : 1557 1566.
16. Coutts AA, Irving AJ, Mackie K, Pertwee RG, Anavi-Goffer S (2002). Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus. J Comp Neurol 448 : 410 422.
17. Cowie AL, Kosterlitz HW, Waterfield AA (1978). Factors influencing the release of acetylcholine from the myenteric plexus of the ileum of the guinea-pig and rabbit.Br. J Pharmacol 64 : 565 580.
18. Croci T, Manara L, Aureggi G, Guagnini F, Rinaldi-Carmona M, Maffrand JP et al. (1998). In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum. Br J Pharmacol 125 : 1393 1395.
19. Duncan M, Mouihate A, Mackie K, Keenan CM, Buckley NE, Davidson JS et al. (2008). Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. Am J Physiol Gastrointest Liver Physiol 295 : G78 87.
20. Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G et al. (2005). Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther 313 : 352 358.
21. 2 receptors. Mol Pharmacol 48 : 443 450.
22. Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I et al. (2002). A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 22 : 9612 9617.
23. Guagnini F, Cogliati P, Mukenge S, Ferla G, Croci T (2006). Tolerance to cannabinoid response on the myenteric plexus of guinea-pig ileum and human small intestinal strips. Br J Pharmacol 148 : 1165 1173.
24. Heinemann A, Shahbazian A, Holzer P (1999). Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways. Neuropharmacology 38 : 1289 1297.
25. Ho WS, Hiley CR (2003). Endothelium-independent relaxation to cannabinoids in rat-isolated mesenteric artery and role of Ca2+ influx. Br J Pharmacol 139 : 585 597.
26. Izzo AA, Mascolo N, Borrelli F, Capasso F (1998). Excitatory transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of cannabinoid CB1 receptors. Br J Pharmacol 124 : 1363 1368.
27. Izzo AA, Mascolo N, Pinto L, Capasso R, Capasso F (1999). The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. Eur J Pharmacol 384 : 37 42.
28. Izzo AA, Mascolo N, Tonini M, Capasso F (2000). Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea-pig ileum. Br J Pharmacol 129 : 984 990.
29. Izzo AA, Fezza F, Capasso R, Bisogno T, Pinto L, Iuvone T et al. (2001). Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. Br J Pharmacol 134 : 563 570.
30. Izzo AA, Capasso F, Costagliola A, Bisogno T, Marsicano G, Ligresti A et al. (2003). An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. Gastroenterology 125 : 765 774.
31. Katayama K, Ueda N, Kurahashi Y, Suzuki H, Yamamoto S, Kato I (1997). Distribution of anandamide amidohydrolase in rat tissues with special reference to small intestine. Biochim Biophys Acta 1347 : 212 218.
32. Landi M, Croci T, Rinaldi-Carmona M, Maffrand JP, Le Fur G, Manara L (2002). Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB1 receptors. Eur J Pharmacol 450 : 77 83.
33. Lopez-Redondo F, Lees GM, Pertwee RG (1997). Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum. Br J Pharmacol 122 : 330 334.
34. Lovinger DM (2007). Endocannabinoid liberation from neurons in transsynaptic signaling. J Mol Neurosci 33 : 87 93.
35. Makwana R, Molleman A, Parsons ME (2004). Inhibition by cannabinoids of the rebound contractions of the rat isolated myenteric plexus longitudinal muscle preparation to electrical field stimulation. Proceedings of the British Pharmacological Society http://www.pa2online.org/Vol2Issue4abst033P.html
36. Makwana R, Molleman A, Parsons ME (2006). The receptors mediating the inhibitory effects of cannabinoids on the electrically stimulated rat isolated myenteric plexus longitudinal muscle preparation are dependent on the frequency of stimulation. Symposium on the cannabinoids, Burlington, Vermont, International Cannabinoid Research Society : 56.
37. Manara L, Croci T, Guagnini F, Rinaldi-Carmona M, Maffrand JP, Le Fur G et al. (1998). Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon. Dig Liver Dis 34 : 262 269.
38. Mang CF, Erbelding D, Kilbinger H (2001). Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. Br J Pharmacol 134 : 161 167.
39. Martin RS, Luong LA, Welsh NJ, Eglen RM, Martin GR, MacLennan SJ (2000). Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human. Br J Pharmacol 129 : 1707 1715.
40. Mascolo N, Izzo AA, Ligresti A, Costagliola A, Pinto L, Cascio MG et al. (2002). The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB J 16 : 1973 1975.
41. Mathison R, Ho W, Pittman QJ, Davison JS, Sharkey KA (2004). Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 : 1247 1254.
42. Nocerino E, Izzo AA, Borrelli F, Capasso F, Capasso R, Pinto A et al. (2002). Relaxant effect of capsazepine in the isolated rat ileum. Naunyn Schmiedebergs Arch Pharmacol 365 : 187 192.
43. Pacheco M, Childers SR, Arnold R, Casiano F, Ward SJ (1991). Aminoalkylindoles: actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257 : 170 183.
44. Paton WD, Zar MA (1968). The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips. J Physiol 194 : 13 33.
45. Pertwee RG (2001). Cannabinoids and the gastrointestinal tract. Gut 48 : 859 867.
46. Pertwee RG (2004). Novel pharmacological targets for cannabinoids. Curr Neuropharmacol 2 : 9 29.
47. Pertwee RG (2005). Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76 : 1307 1324.
48. Pertwee RG, Fernando SR (1996). Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder. Br J Pharmacol 118 : 2053 2058.
49. Pertwee RG, Stevenson LA, Elrick DB, Mechoulam R, Corbett AD (1992). Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea-pig small intestine. Br J Pharmacol 105 : 980 984.
50. Pertwee RG, Fernando SR, Nash JE, Coutts AA (1996). Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine. Br J Pharmacol 118 : 2199 2205.
51. Rinaldi-Carmona M, Barth F, Héaulme M, Shire D, Calandra B, Congy C et al. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350 : 240 244.
52. Rinaldi-Carmona M, Barth F, Millan J, Derocq JM, Casellas P, Congy C et al. (1998). SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J Pharmacol Exp Ther 284 : 644 650.
53. Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J et al. (2007). The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. doi: 10.1038/sj.bjp.070746.
54. Schild HO (1949). pAx and competitive drug antagonism. Br J Pharmacol 4 : 277 228.
55. Showalter VM, Compton DR, Martin BR, Abood ME (1996). Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278 : 989 999.
56. Shire D, Calandra B, Rinaldi-Carmona M, Oustric D, Pessegue B, Bonnin-Cabanne O et al. (1996). Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim Biophys Acta 1307 : 132 136.
57. Shook JE, Burks TF (1989). Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. J Pharmacol Exp Ther 249 : 444 449.
58. Smart D, Gunthorpe MJ, Jerman JC, Nasir S, Gray J, Muir AI et al. (2000). The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol 129 : 227 230.
59. Storr M, Gaffal E, Saur D, Schusdziarra V, Allescher HD (2002). Effect of cannabinoids on neural transmission in rat gastric fundus. Can J Physiol Pharmacol 80 : 67 76.
60. Valenti M, Gianfrani C, Mukenge S, Scaglione G, D'Argenio G, Ferla G, Mazzarella G et al. (2005). Involvement of endocannabinoids and palmitoylethanolamide in intestinal disorders with inflammatory complications: human studies. Symposium on the cannabinoids, Burlington, Vermont, International Cannabinoid Research Society : 158.
61. Valiveti S, Kiptoo PK, Hammell DC, Stinchcomb AL (2004). Transdermal permeation of WIN 55 212-2 and CP 55 940 in human skin in vitro. Int J Pharm 278 : 173 180.
62. Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sorgard M, Di Marzo V et al. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 : 452 457.