Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection

Infection and Immunity

Volumn 78, Issue 4, 2010, Pages 1740-1749

  Moen, Scott T ^a   Blumentritt, Carla A ^a   Slater, Terry M ^a   Patel, Shilpa D ^a   Tutt, Christopher B ^a   Estrella Jimenez, Maria E ^a   Pawlik, Jennifer ^a   Sower, Laurie ^a   Popov, Vsevolod L ^a   Schein, Catherine H ^a   Gilbertson, Scott R ^a,b   Peterson, Johnny W ^a   Torres, Alfredo G ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [( 9 OXO 9H FLUORENE 1 CARBONYL)AMINO]BENZOIC ACID; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; CYCLIC AMP; DC 5; FLUORENONE DERIVATIVE; IMIDAZOLE; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM ADHERENCE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DIARRHEA; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; ENTEROBACTERIACEAE; EPITHELIUM CELL; ESCHERICHIA COLI; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENYLATE CYCLASE; ADHESINS, BACTERIAL; ANIMALS; BACTERIAL ADHESION; BACTERIAL TOXINS; CELL LINE; COLONY COUNT, MICROBIAL; ENTEROTOXIGENIC ESCHERICHIA COLI; ENTEROTOXINS; ENZYME INHIBITORS; EPITHELIAL CELLS; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FEMALE; FLUORENES; HUMANS; INHIBITORY CONCENTRATION 50; INTESTINE, SMALL; MACROPHAGES; MICE;

EID: 77950286812     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01114-09     Document Type: Article

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