Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 24, 2008, Pages 8440-8445

  Kots, Alexander Y ^a   Choi, Byung Kwon ^a   Estrella Jimenez, Maria E ^b   Warren, Cirle A ^c   Gilbertson, Scott R ^b   Guerrant, Richard L ^c   Murad, Ferid ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Adenylyl cyclase; cAMP; cGMP; Guanylyl cyclase; Toxin induced diarrhea

Indexed keywords

5 (3 BROMOPHENYL) 1,3 DIMETHYL 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6 TRIONE; ADENYLATE CYCLASE; BACTERIAL TOXIN; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; GUANYLATE CYCLASE; PHOSPHOLIPASE C; PYRIDOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS ANTHRACIS; BORDETELLA PERTUSSIS; CONTROLLED STUDY; DIARRHEA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; RAT;

ADENYLATE CYCLASE; ANIMALS; ANTIDIARRHEALS; BACTERIAL TOXINS; CELL LINE; CRICETINAE; CYCLIC AMP; CYCLIC GMP; DIARRHEA; ENTEROTOXINS; ENZYME INHIBITORS; GUANYLATE CYCLASE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; RATS; SMALL MOLECULE LIBRARIES;

BACILLUS ANTHRACIS; BORDETELLA PERTUSSIS; ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS;

EID: 46149094634     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803096105     Document Type: Article

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