2-cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: Structure-activity in vitro and efficacy in vivo

Journal of Medicinal Chemistry

Volumn 40, Issue 15, 1997, Pages 2335-2346

  Naylor, Matthew A ^a   Jaffar, Mohammed ^b   Nolan, John ^c   Stephens, Miriam A ^c   Butler, Susan ^c   Patel, Kantilal B ^a   Everett, Steven A ^a   Adams, Gerald E ^a   Stratford, Ian J ^b  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (HYDROXYMETHYL) 5 (2 METHYLAZIRIDIN 1 YL) 1,2 DIMETHYLINDOLE 4,7 DIONE; 5 (AZIRIDIN 1 YL) 2 CYCLOPROPYL 3 (HYDROXYMETHYL) 1 METHYLINDOLE 4,7 DIONE; ANTINEOPLASTIC AGENT; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STABILITY; DRUG SYNTHESIS; HYPOXIC CELL; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CELL HYPOXIA; CELL LINE; CRICETINAE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; OXIDATION-REDUCTION; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0030747303     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9608422     Document Type: Article

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