Effect of occupational exposure to cytostatics and nucleotide excision repair polymorphism on chromosomal aberrations frequency

Interdisciplinary Toxicology

Volumn 2, Issue 1, 2009, Pages 13-17

  Mušák, L'udovit ^a   Halašová, Erika ^a   Osina, Oto ^a   Poláková, Veronika ^b   Vodièková, Ludmila ^b   Vodièka, Pavel ^c   Buchancová, Janka ^a   Hudeèková, Henrieta ^a  

^a University Hospital in Martin   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^c NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77950223213     PISSN: 13376853     EISSN: 13379569     Source Type: Journal    
DOI: 10.2478/v10102-009-0002-6     Document Type: Article

References (32)

1. AHEM. (2007). Metody biologického monitorování genotoxických účinku faktoru prostredí. Cytogenetická analýza periferních lymfocytu. Aktualizácia platnej štandardnej metodiky. AHEM 1/2007, SZÚ, Praha, 30 pp.
2. Angelini S, Kumar R, Carbone F, Bermejo JL, Maffei F, Cantelli-Forti G, Hemminki K and Hrelia P. (2008). Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. Mutat Res 638: 90-97.
3. Burgaz S, Karahalil B, Canhi Z, Terzioglu F, Ancel G, Anzion RB, Bos RP and Hüttner E. (2002). Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations. Hum Exp Toxicol 21: 129-135.
4. Cavallo D, Ursini CL, Omodeo-Sale E and Iavicoli S. (2007). Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs. Mutat Res 628: 11-18.
5. Cavallo D, Ursini LC, Perniconi B, Di Francesco A, Giglio M, Rubino FM., Marinaccio A and Iavicoli S. (2005). Evaluation of genotoxic effects induced exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat Res 587: 45-51.
6. Connor TH. (2006). Hazardous anticancer drugs in health care: environmental exposure assessment. Ann N Acad Sci 1076: 615-623.
7. Deng H, Hang M, He J, Wu W, Jin L, Zheng W, Lou J and Wang B. (2005). Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis 20: 351-357.
8. Fransman W, Huizer D, Tuerk J and Kromhout H. (2007a). Inhalation and dermal exposure to eight antineoplastic drugs in an industrial laundry facility. Int Arch Occup Environ Health 80: 396-403.
9. Fransman W, Roeleveld N, Peelen S, de Kort W, Kromhout H and Heederik D. (2007b). Nurses with dermal exposure to antineoplastic drugs: reproductive outcomes. Epidemiology 18: 112-119.
10. Fransman W, Vermeulen R and Kromhout H. (2005). Dermal exposure to cyclophosphamide in hospitals during preparation, nursing and cleaning activities. Int Arch Occup Environ Health 78: 403-412.
11. Hemminki K. (2001). Biomarkers of exposure and effect for carcinogenicity. Appendix I. In: WHO Library Cataloguing-in-Publication Data, Biomarkers in risk assessment: validity and validation (Environmental health criteria) 222, WHO, Geneva, 241pp, 47-94.
12. Hou SM, Fält S, Angelini S, Yang K, Nyberg F, Lambert B and Hemminki K. (2002). The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis 23: 599-603.
13. Kumar R, Höglund L, Zhao CH, Försti A, Snellman E and Hemminki K. (2003). Single nucleotide polymorphisms in the XPG gene: determination of role in DNA repair and breast cancer risk. Int J Cancer 103: 671-675.
14. Laczmanska I, Gil J, Karpinski P, Stembalska A, Trusewicz A, Pesz K, Ramsey D, Schlade-Bartusiak K, Blin N and Sasiadek MM. (2007). Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. Environ Mol Mutagen 48: 666-671.
15. Major J, Jakab MG and Tompa A. (1999). The frequency of induced premature centromere division in human populations occupationally exposed to genotoxic. Mutat Res 445: 241-249.
16. Maluf SW and Erdtmann B. (2000). Follow-up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis. Mutat Res 471: 21-27.
17. Mohrenweiser HW, Xi T, Vazquez-Matias J and Jones IM. (2002). Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans. Cancer Epidemiol Biomarkers Prev 11: 1054-1064.
18. Musak L, Vodicka P, Klimentová G, Soucek P, Hánová M, Mikulková R, Buchancová J, Vodicková L, Poláková V and Péc M. (2006). Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics. Neuro Endocrinol Lett 27 (Suppl 2): 57-60.
19. Norppa H. (2004). Cytogenetic biomarkers and genetic polymorphisms. Toxicol Lett 149: 309-334.
20. Norppa H. (2003). Genetic susceptibility, biomarker responses, and cancer. Mutat Res 544: 339-348.
21. Pilger A, Köhler I, Stettner H, Mader RM, Rizovski B, Terkola R, Diem E, Franz-Hainzl E, Konnaris CM Valic E and Rüdinger HW. (2000). Long-term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personnel occupationally exposed to cytostatic drugs. Int Arch Occup Environ Health 73: 442-448.
22. Rekhadevi PV, Sailaja N, Chandrasekhar M, Mahboob M, Rahman MF and Grover P. (2007). Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs. Mutagenesis 22: 395-401.
23. Rombaldi F, Cassini C, Salvator M, Saffi J and Erdtmann B. (2009). Occupational risk assessment of genotoxicity and oxidative stress in workers handling antineoplastic drugs during a working week. Mutagenesis 24: 143-148.
24. Rubes J, Kucharová S, Vozdová M, Musilová P and Zudová Z. (1998). Cytogenetic analysis of peripheral lymphocytes in medical personnel by means of FISH. Mutat Res 412: 293-298.
25. Skjelbred CF, Svendsen M, Haugan V, Eek AK, Clausen KO, Svendsen MV and Hansteen IL. (2006). Infl uence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies. Mutat Res 602: 151-162.
26. Sudprasert W, Navasumrit P and Ruchirawat M. (2006). Effects of low-dose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells. Int J Hyg Environ Health 209: 503-511.
27. Testa A, Giachelia M, Palma S, Appolloni M, Padua L, Tranfo G, Spagnoli M, Tirindelli D and Cozzi R. (2007). Occupational exposure to antineoplastic agents induces a high level of chromosome damage. Lack of an effect of GST polymorphisms. Toxicol Appl Pharmacol 223: 46-55.
28. Tuimala J, Szekely G, Gundy S, Hirvonen A and Norppa H. (2002). Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. Carcinogenesis 23: 1003-1008.
29. Tuimala J, Szekely G, Wikman H, Järventaus H, Hirvonen A, Gundy S and Norppa H. (2004). Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations. Mutat Res 554: 319-333. Erratum in Mutat Res 2005, 570: 303.
30. Vodicka P, Kumar R, Stetina R, Sanyal S, Soucek P, Haufroid V, Dusinska M, Kuricova M, Zamecnikova M, Musak L, Buchancova J, Norppa H, Hirvonen A, Vodickova L, Naccarati A, Matousu Z and Hemminki K. (2004). Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis 25: 757-763.
31. Vorlícek J, Vyzula R and Adam Z. (2000). Praktická onkologie, Vybrané kapitoly. Grada Publishing s.r.o., Praha, pp.77-154.
32. Wick U and Gebhart E (2005). Studies on the action of mitomycin C and bleomycin on telomere lengths of human lymphocyte chromosomes. Int J Mol Med 16: 463-469.