Inhalation and dermal exposure to eight antineoplastic drugs in an industrial laundry facility

International Archives of Occupational and Environmental Health

Volumn 80, Issue 5, 2007, Pages 396-403

  Fransman, Wouter ^a   Huizer, Daan ^b   Tuerk, Jochen ^b   Kromhout, Hans ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b Institute of Energy and Environmental Technology IUTA   (Germany)

Author keywords

Antineoplastic drugs; Hospital laundry; Laundry facility; LC MS MS; Occupational exposure

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; IFOSFAMIDE; METHOTREXATE;

ARTICLE; BED; CONTAMINATION; DRUG EXPOSURE; HUMAN; INHALATION; LAUNDRY; MASS SPECTROMETRY; MATERIALS HANDLING; NETHERLANDS; OCCUPATIONAL EXPOSURE; PRACTICE GUIDELINE; QUANTITATIVE ANALYSIS; WORK SCHEDULE;

ANTINEOPLASTIC AGENTS; BEDDING AND LINENS; HUMANS; INHALATION EXPOSURE; LAUNDERING; NETHERLANDS; OCCUPATIONAL EXPOSURE; SKIN ABSORPTION;

EID: 33847660588     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-006-0148-x     Document Type: Article

References (18)

1. Brouwer DH, Boeniger MF, van Hemmen JJ (2000) Hand wash and manual skin wipes. Ann Occup Hyg 44:501-510
2. Fransman W, Vermeulen R, Kromhout H (2004) Occupational dermal exposure to cyclophosphamide in Dutch hospitals: A pilot study. Ann Occup Hyg 48:237-244
3. Fransman W, Vermeulen R, Kromhout H (2005) Dermal exposure to cyclophosphamide in hospitals during preparation, nursing and cleaning activities. Int Arch Occup Environ Health 78:403-412
4. FTN (2006) Inzamelingsonderzoek cytostatica. Report Federatie Textiel Beheer (in Dutch)
5. Goloni-Bertollo EM, Tajara EH, Manzato AJ, Varella-Garcia M (1992) Sister chromatid exchanges and chromosome aberrations in lymphocytes of nurses handling antineoplastic drugs. Int J Cancer 50:341-344
6. Kromhout H, Hoek F, Uitterhoeve R, Huijbers R, Overmars RF, Anzion R, Vermeulen R (2000) Postulating a dermal pathway for exposure to anti-neoplastic drugs among hospital workers. Applying a conceptual model to the results of three workplace surveys. Ann Occup Hyg 44:551-560
7. McDevitt JJ, Lees PS, McDiarmid MA (1993) Exposure of hospital pharmacists and nurses to antineoplastic agents. J Occup Med 35:57-60
8. Meijster T, Fransman W, Veldhof R, Kromhout H (2006) Exposure to antineoplastic drugs outside the hospital environment. Ann Occup Hyg 10.1093/annhyg/mel023
9. Milkovic-Kraus S, Horvat D (1991) Chromosomal abnormalities among nurses occupationally exposed to antineoplastic drugs. Am J Ind Med 19:771-774
10. Pohlová H, Cernà M, Rössner P (1986) Chromosomal aberrations, SCE and urine mutagenicity in workers occupationally exposed to cytostatic drugs. Mutat Res 174:213-217
11. Sardas S, Gök S, Karakaya AE (1991) Sister chromatid exchanges in lymphocytes of nurses handling antineoplastic drugs. Toxicol Lett 55:311-315
12. Selevan SG, Lindbohm ML, Hornung RW, Hemminki K (1985) A study of occupational exposure to antineoplastic drugs and fetal loss in nurses. N Engl J Med 313:1173-1178
13. Sessink PJ, Cerna M, Rossner P, Pastorkova A, Bavarova H, Frankova K, Anzion RB, Bos RP (1994a) Urinary cyclophosphamide excretion and chromosomal aberrations in peripheral blood lymphocytes after occupational exposure to antineoplastic agents. Mutat Res 309:193-199
14. Sessink PJ, van de Kerkhof MC, Anzion RB, Noordhoek J, Bos RP (1994b) Environmental contamination and assessment of exposure to antineoplastic agents by determination of cyclophosphamide in urine of exposed pharmacy technicians: Is skin absorption an important exposure route? Arch Environ Health 49:165-169
15. Sessink PJM, Boer KA, Scheefhals APH, Anzion RBM, Bos RP (1992) Occupational exposure to antineoplastic agents at several departments in a hospital. Environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers. Int Arch Occup Environ Health 64:105-112
16. Stücker I, Caillard JF, Collin R, Gout M, Poyen D, Hemon D (1990) Risk of spontaneous abortion among nurses handling antineoplastic drugs. Scand J Work Environ Health 16:102-107
17. Türk J, Stellwag N, Reinders M, Kiffmeyer TK, Schöppe G, Schmidt KG (2002) Kontamination von Krankenhauswäsche mit hochwirksamen Arzneimitteln. Wie effektiv sind die derzeitigen Reinigungsverfahren? [article in German]. Wäscherei Reinigungspraxis 11:24-27
18. Waksvik H, Klepp O, Brogger A (1981) Chromosome analyses of nurses handling cytostatic agents. Cancer Treat Rep 65:607-610