Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice

Stroke

Volumn 41, Issue 4, 2010, Pages 790-797

  Wakisaka, Yoshinobu ^a   Chu, Yi ^a   Miller, Jordan D ^a   Rosenberg, Gary A ^d   Heistad, Donald D ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b Department of Pharmacology ^*  (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

MMP 9 and brain hemorrhage; Oxidative stress; SOD1

Indexed keywords

ANGIOTENSIN II; COPPER ZINC SUPEROXIDE DISMUTASE; DRINKING WATER; GELATINASE B; MATRIX METALLOPROTEINASE; NITRIC OXIDE SYNTHASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; HYPERTENSION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STROKE; TRANSGENIC MOUSE; WILD TYPE;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; BRAIN; CEREBRAL HEMORRHAGE; ENZYME ACTIVATION; HUMANS; HYPERTENSION; MALE; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NADPH OXIDASE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 77950209646     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.569616     Document Type: Article

References (13)

1. Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD. Spontaneous stroke in a genetic model of hypertension in mice. Stroke. 2005;36:1253-1258.
2. Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD. Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice. J Cereb Blood Flow Metab. 2010;30:56-69.
3. Gasche Y, Copin JC, Sugawara T, Fujimura M, Chan PH. Matrix met-alloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2001;21:1393-1400.
4. Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91:938-944.
5. Didion SP, Kinzenbaw DA, Faraci FM. Critical role for CuZn-superoxide dismutase in preventing angiotensin-II-induced endothelial dysfunction. Hypertension. 2005;46:1147-1153.
6. Morita-Fujimura Y, Fujimura M, Gasche Y, Copin JC, Chan PH. Overex-pression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma. J Cereb Blood Flow Metab. 2000;20:130-138.
7. Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD. Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. J Cereb Blood Flow Metab. 2008;28:1175-1185.
8. Chu Y, Heistad DD, Knudtson KL, Lamping KG, Faraci FM. Quantification of mRNA for endothelial NO synthase in mouse blood vessels by real-time polymerase chain reaction. Arterioscler Thromb Vasc Biol. 2002;22:611-616.
9. Faraci FM, Didion SP. Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol. 2004;24:1367-1373.
10. Baumbach GL, Didion SP, Faraci FM. Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dis-mutase. Stroke. 2006;37:1850-1855.
11. Fujimura M, Morita-Fujimura Y, Narasimhan O, Copin JC, Kawase M, Chan PH. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyriminic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke. 1999;30:2408-2415.
12. Kamada H, Yu F, Nito C, Chan PH. Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats. Relation to blood-brain barrier dysfunction. Stroke. 2007;38:1044-1049.
13. Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci. 1997;17: 4180-4189.