Methylphenidate facilitates learning-induced amygdala plasticity

Nature Neuroscience

Volumn 13, Issue 4, 2010, Pages 475-481

  Tye, Kay M ^a,b   Tye, Lynne D ^a,c   Cone, Jackson J ^a   Hekkelman, Evelien F ^a   Janak, Patricia H ^a,b,d   Bonci, Antonello ^a,b,d  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; METHYLPHENIDATE; NORADRENALIN TRANSPORTER;

ACUTE DRUG ADMINISTRATION; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; ATTENTION DEFICIT DISORDER; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EX VIVO STUDY; IN VIVO STUDY; LEARNING; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; REWARD; SYNAPSE;

AMYGDALA; ANIMALS; LEARNING; MALE; METHYLPHENIDATE; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77950187913     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2506     Document Type: Article

References (50)

1. Swanson, J.M., Lerner, M. & Williams, L. More frequent diagnosis of attention defcit-hyperactivity disorder. N. Engl. J. Med. 333, 944 (1995).
2. Aman, M.G., Vamos, M. & Werry, J.S. Effects of methylphenidate in normal adults with reference to drug action in hyperactivity. Aust. N. Z. J. Psychiatry 18, 86-88 (1984).
3. American Psychiatric Association. ed. Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Publishing, Arlington, Virginia, USA, 1994).
4. Rodriguez, A. et al. Do inattention and hyperactivity symptoms equal scholastic impairment? Evidence from three European cohorts. BMC Public Health 7, 327 (2007).
5. Greenhill, L.L. et al. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J. Am. Acad. Child Adolesc. Psychiatry 41, 26S-49S (2002).
6. Yang, P. , Chung, L.C., Chen, C.S. & Chen, C.C. Rapid improvement in academic grades following methylphenidate treatment in attention-defcit hyperactivity disorder. Psychiatry Clin. Neurosci. 58, 37-41 (2004).
7. LeDoux, J. The emotional brain, fear, and the amygdala. Cell. Mol. Neurobiol. 23, 727-738 (2003).
8. Tye, K.M., Stuber, G.D., de Ridder, B., Bonci, A. & Janak, P.H. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature 453, 1253-1257 (2008).
9. Cardinal, R.N., Parkinson, J.A., Hall, J. & Everitt, B.J. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci. Biobehav. Rev. 26, 321-352 (2002).
10. Cador, M., Robbins, T.W. & Everitt, B.J. Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum. Neuroscience 30, 77-86 (1989).
11. Davis, M. The role of the amygdala in emotional learning. Int. Rev. Neurobiol. 36, 225-266 (1994).
12. Schoenbaum, G., Chiba, A.A. & Gallagher, M. Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nat. Neurosci. 1, 155-159 (1998).
13. Plessen, K.J. et al. Hippocampus and amygdala morphology in attention-defcit/ hyperactivity disorder. Arch. Gen. Psychiatry 63, 795-807 (2006).
14. Doron, N.N. & Ledoux, J.E. Organization of projections to the lateral amygdala from auditory and visual areas of the thalamus in the rat. J. Comp. Neurol. 412, 383-409 (1999).
15. Nakashima, M. et al. An anterograde and retrograde tract-tracing study on the projections from the thalamic gustatory area in the rat: distribution of neurons projecting to the insular cortex and amygdaloid complex. Neurosci. Res. 36, 297-309 (2000).
16. Reijmers, L.G., Perkins, B.L., Matsuo, N. & Mayford, M. Localization of a stable neural correlate of associative memory. Science 317, 1230-1233 (2007).
17. Han, J.H. et al. Selective erasure of a fear memory. Science 323, 1492-1496 (2009).
18. Tye, K.M. & Janak, P.H. Amygdala neurons differentially encode motivation and reinforcement. J. Neurosci. 27, 3937-3945 (2007).
19. Zheng, X., Liu, F. , Wu, X. & Li, B. Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats. Sci. China C Life Sci. 51, 808-813 (2008).
20. Markowitz, J.S., DeVane, C.L., Pestreich, L.K., Patrick, K.S. & Muniz, R. A comprehensive in vitro screening of d-, l-, and dl-threo- methylphenidate: an exploratory study. J. Child Adolesc. Psychopharmacol. 16, 687-698 (2006).
21. Solanto, M.V. Neuropsychopharmacological mechanisms of stimulant drug action in attention-defcit hyperactivity disorder: a review and integration. Behav. Brain Res. 94, 127-152 (1998).
22. Dougherty, D.D. et al. Dopamine transporter density in patients with attention defcit hyperactivity disorder. Lancet 354, 2132-2133 (1999).
23. Waldman, I.D. et al. Association and linkage of the dopamine transporter gene and attention-defcit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am. J. Hum. Genet. 63, 1767-1776 (1998).
24. Volkow, N.D. et al. Therapeutic doses of oral methylphenidate signifcantly increase extracellular dopamine in the human brain. J. Neurosci. 21, RC121 (2001).
25. Volkow, N.D. et al. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am. J. Psychiatry 155, 1325-1331 (1998).
26. Andersen, P.H. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur. J. Pharmacol. 166, 493-504 (1989).
27. Bissiere, S., Humeau, Y. & Luthi, A. Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Nat. Neurosci. 6, 587-592 (2003).
28. Malenka, R.C. & Nicoll, R.A. Long-term potentiation-a decade of progress? Science 285, 1870-1874 (1999).
29. Hess, G., Kuhnt, U. & Voronin, L.L. Quantal analysis of paired-pulse facilitation in guinea pig hippocampal slices. Neurosci. Lett. 77, 187-192 (1987).
30. Hitchcott, P.K., Harmer, C.J. & Phillips, G.D. Enhanced acquisition of discriminative approach following intra-amygdala d-amphetamine. Psychopharmacology (Berl.) 132, 237-246 (1997).
31. Bernal, S. et al. Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned favor preferences in rats. Behav. Brain Res. 205, 183-190 (2009).
32. Hitchcott, P.K., Bonardi, C.M. & Phillips, G.D. Enhanced stimulus-reward learning by intra-amygdala administration of a D3 dopamine receptor agonist. Psychopharmacology (Berl.) 133, 240-248 (1997).
33. Touzani, K., Bodnar, R.J. & Sclafani, A. Dopamine D1-like receptor antagonism in amygdala impairs the acquisition of glucose-conditioned favor preference in rats. Eur. J. Neurosci. 30, 289-298 (2009).
34. Andrzejewski, M.E., Spencer, R.C. & Kelley, A.E. Instrumental learning, but not performance, requires dopamine D1-receptor activation in the amygdala. Neuroscience 135, 335-345 (2005).
35. Lamont, E.W. & Kokkinidis, L. Infusion of the dopamine D1 receptor antagonist SCH 23390 into the amygdala blocks fear expression in a potentiated startle paradigm. Brain Res. 795, 128-136 (1998).
36. Guarraci, F.A., Frohardt, R.J., Young, S.L. & Kapp, B.S. A functional role for dopamine transmission in the amygdala during conditioned fear. Ann. NY Acad. Sci. 877, 732-736 (1999).
37. Guarraci, F.A., Frohardt, R.J., Falls, W.A. & Kapp, B.S. The effects of intra-amygdaloid infusions of a D2 dopamine receptor antagonist on Pavlovian fear conditioning. Behav. Neurosci. 114, 647-651 (2000).
38. Greba, Q., Gifkins, A. & Kokkinidis, L. Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle. Brain Res. 899, 218-226 (2001).
39. Rosenkranz, J.A. & Grace, A.A. Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning. Nature 417, 282-287 (2002).
40. Kienast, T. et al. Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nat. Neurosci. 11, 1381-1382 (2008).
41. Kroner, S., Rosenkranz, J.A., Grace, A.A. & Barrionuevo, G. Dopamine modulates excitability of basolateral amygdala neurons in vitro. J. Neurophysiol. 93, 1598-1610 (2005).
42. Loretan, K., Bissiere, S. & Luthi, A. Dopaminergic modulation of spontaneous inhibitory network activity in the lateral amygdala. Neuropharmacology 47, 631-639 (2004).
43. Marowsky, A., Yanagawa, Y., Obata, K. & Vogt, K.E. A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function. Neuron 48, 1025-1037 (2005).
44. Rosenkranz, J.A. & Grace, A.A. Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats. J. Neurosci. 21, 4090-4103 (2001).
45. Moron, J.A., Brockington, A., Wise, R.A., Rocha, B.A. & Hope, B.T. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J. Neurosci. 22, 389-395 (2002).
46. Cornish, J.L. & Kalivas, P.W. Repeated cocaine administration into the rat ventral tegmental area produces behavioral sensitization to a systemic cocaine challenge. Behav. Brain Res. 126, 205-209 (2001).
47. Steketee, J.D. Repeated injection of GBR 12909, but not cocaine or WIN 35,065-2, into the ventral tegmental area induces behavioral sensitization. Behav. Brain Res. 97, 39-48 (1998).
48. Macedo, C.E., Martinez, R.C., Albrechet-Souza, L., Molina, V.A. & Brandao, M.L. 5-HT2-and D1-mechanisms of the basolateral nucleus of the amygdala enhance conditioned fear and impair unconditioned fear. Behav. Brain Res. 177, 100-108 (2007).
49. Berglind, W.J., Case, J.M., Parker, M.P., Fuchs, R.A. & See, R.E. Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking. Neuroscience 137, 699-706 (2006).
50. See, R.E., Kruzich, P.J. & Grimm, J.W. Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. Psychopharmacology (Berl.) 154, 301-310 (2001).