Dose-dependent long-term effects of tat in the rat hippocampal formation: A design-based stereological study

Hippocampus

Volumn 20, Issue 4, 2010, Pages 469-480

  Fitting, Sylvia ^a   Booze, Rosemarie M ^a,b   Hasselrot, Ulla ^a   Mactutus, Charles F ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Glia; Hippocampus; Neurons; Stereology; Tat

Indexed keywords

TRANSACTIVATOR PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN GROWTH; BRAIN NERVE CELL; CELL COUNT; CENTRAL NERVOUS SYSTEM INFECTION; DELIVERY; DENTATE GYRUS; DISEASE COURSE; FEMALE; HIPPOCAMPUS; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LABOR; MALE; NEUROTOXICITY; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; STEREOLOGY; SUBICULUM;

ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HIPPOCAMPUS; MALE; NEURONS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TIME;

EID: 77950183025     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20648     Document Type: Article

References (31)

1. Aksenova MV, Aksenov MY, Mactutus CF, Booze RM. 2005. Cell culture models of oxidative stress and injury in the central nervous system. Curr Neurovasc Res 2:73-89.
2. Aksenova MV, Silvers JM, Aksenov MY, Nath A, Ray PD, Mactutus CF, Booze RM. 2006. HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: Changes in dopamine transporter binding and immunoreactivity. Neurosci Lett 395:235-239.
3. Aksenov MY, Hasselrot U, Bansal AK, Wu G, Nath A, Anderson C, Mactutus CF, Booze RM. 2001. Oxidative damage induced by the injection of HIV-1 Tat protein in the rat striatum. Neurosci Lett 305:5-8.
4. Aksenov MY, Hasselrot U, Wu G, Nath A, Anderson C, Mactutus CF, Booze RM. 2003. Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum. Brain Res 987:1-9.
5. Aksenov MY, Aksenova MV, Nath A, Ray PD, Mactutus CF, Booze RM. 2006. Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: The role of oxidative stress and D1 dopamine receptor. Neurotoxicology 27:217-228.
6. Annunziata P. 2003. Blood-brain barrier changes during invasion of the central nervous system by HIV-1. Old and new insights into the mechanism. J Neurol 250:901-906.
7. Bansal AK, Mactutus CF, Nath A, Maragos W, Hauser KF, Booze RM. 2000. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum. Brain Res 879:42-49.
8. Belman AL. 1997. Infants, children, and adolescents. In Berger JR, Levy RM, editors. AIDS and the Nervous System, 2nd ed. Philadelphia: Lippincott-Raven. pp 223-253.
9. Blanche S, Tardieu M, Duliege A, Rouzioux C, Le Deist F, Fukunaga K, Caniglia M, Jacomet C, Messiah A, Griscelli C. 1990. Longitudinal study of 94 symptomatic infants with perinatally acquired human immunodeficiency virus infection. Evidence for a bimodal expression of clinical and biological symptoms. AMA Am J Dis Child 144:1210-1215.
10. Brigati C, Giacca M, Noonan DM, Albini A. 2003. HIV Tat, its TARgets and the control of viral gene expression. FEMS Microbiol Lett 220:57-65.
11. Bruce-Keller AJ, Chauhan A, Dimayuga FO, Gee J, Keller JN, Nath A. 2003. Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J Neurosci 23:8417-8422.
12. Catani MV, Corasaniti MT, Ranalli M, Amantea D, Litovchick A, Lapidot A, Melino G. 2003. The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells. J Neurochem 84:1237-1245.
13. Chearskul S, Chotpitayasunondh T, Simonds RJ, Wanprapar N, Waranawat N, Punpanich W, Chokephaibulkit K, Mock PA, Neeyapun K, Jetsawang B, Teeraratkul A, Supapol W, Mastro TD, Shaffer N; Bangkok Collaborative Perinatal HIV Transmission Study Group. 2002. Survival, disease manifestations, and early predictors of disease progression among children with perinatal human immunodeficiency virus infection in Thailand. Pediatrics 110(2 Pt 1):e25.
14. Cheng J, Nath A, Knudsen B, Hochman S, Geiger JD, Ma M, Magnuson DS. 1998. Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience 82:97-106.
15. Dodd EE. 1979. Atlas of Histology. New York: McGraw-Hill Inc. Epstein LG, Sharer LR, Oleske JM, Connor EM, Goudsmit J, Bagdon L, Robert-Guroff M, Koenigsberger MR. 1986. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics 78:678-687.
16. Equils O, Garratty E, Wei LS, Plaeger S, Tapia M, Deville J, Krogstad P, Sim MS, Nielsen K, Bryson YJ. 2000. Recovery of replication-competent virus from CD4 T cell reservoirs and change in coreceptor use in human immunodeficiency virus type 1-infected children responding to highly active antiretroviral therapy. J Infect Dis 182:751-757.
17. Fitting S, Booze RM, Mactutus CF. 2006. Neonatal hippocampal Tat injections: Developmental effects on prepulse inhibition (PPI) of the auditory startle response. Int J Dev Neurosci 24:275-283.
18. Fitting S, Booze RM, Hasselrot U, Mactutus CF. 2008a. Differential long-term neurotoxicity of HIV-1 proteins in the rat hippocampal formation: A design-based stereological study. Hippocampus 18:135-147.
19. Fitting S, Booze RM, Mactutus CF. 2008b. Neonatal intrahippocampal injection of the HIV-1 proteins gp120 and Tat: Differential effects on behavior and the relationship to stereological hippocampal measures. Brain Res 1232:139-154.
20. Fowler MG. 1994. Pediatric HIV infection: neurologic and neuropsychologic findings. Acta Paediatr Suppl 400:59-62.
21. Gelbard HA, Epstein LG. 1995. HIV-1 encephalopathy in children. Curr Opin Pediatr 7:655-662.
22. Gelbard HA, James HJ, Sharer LR, Perry SW, Saito Y, Kazee AM, Blumberg BM, Epstein LG. 1995. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 21:208-217.
23. Greenhouse SW, Geisser S. 1959. On methods in the analysis of profile data. Psychometrika 24:95-112.
24. Gundersen HJ, Jensen EB, Kieu K, Nielsen J. 1999. The efficiency of systematic sampling in stereology-reconsidered. J Microsc 193(Pt 3):199-211.
25. James HJ, Sharer LR, Zhang Q, Wang HG, Epstein LG, Reed JC, Gelbard HA. 1999. Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis. Neuropathol Appl Neurobiol 25:380-386.
26. Jones MV, Bell JE, Nath A. 2000. Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia. AIDS 14:2709-2713.
27. Kourtis AP, Bulterys M, Nesheim SR, Lee FK. 2001. Understanding the timing of HIV transmission from mother to infant. JAMA 285:709-712.
28. Krajewski S, James HJ, Ross J, Blumberg BM, Epstein LG, Gendelman HE, Gummuluru S, Dewhurst S, Sharer LR, Reed JC, Gelbard HA. 1997. Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis. Neuropathol Appl Neurobiol 23:242-253.
29. Li ST, Matsushita M, Moriwaki A, Saheki Y, Lu YF, Tomizawa K, Wu HY, Terada H, Matsui H. 2004. HIV-1 inhibits long-term potentiation and attenuates spatial learning. Ann Neurol 55:362-371.
30. Lister JP, Blatt GJ, DeBassio WA, Kemper TL, Tonkiss J, Galler JR, Rosene DL. 2005. Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus 15:393-403.
31. Ma M, Nath A. 1997. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 71:2495-2499.