The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells

Journal of Neurochemistry

Volumn 84, Issue 6, 2003, Pages 1237-1245

  Catani, Maria Valeria ^a   Corasaniti, Maria Tiziana ^b   Ranalli, Marco ^a   Amantea, Diana ^b   Litovchick, Alexander ^c   Lapidot, Aviva ^c   Melino, Gerry ^a,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Aminoglycoside arginine conjugate; Blood brain barrier; Cell death; Chemokine receptors; Gp 120; Neomycin B hexa arginine conjugate

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; FLUORESCEIN; GLYCOPROTEIN GP 120; NEOMYCIN B HEXAARGININE CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG PENETRATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; CELL DEATH; FLUORESCENT DYES; FRAMYCETIN; GENE PRODUCTS, TAT; HIV ENVELOPE PROTEIN GP120; HUMANS; MICE; NEUROBLASTOMA; RECEPTORS, CCR5; RECEPTORS, CXCR4; TUMOR CELLS, CULTURED;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037343948     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01620.x     Document Type: Article

References (38)

1. Bagetta G., Corasaniti M. T., Berliocchi L., Navarra M., Finazzi-Agrò A. and Nisticò G. (1995) HIV-1 gp-120 produces DNA fragmentation in the cerebral cortex of rat. Biochem. Biophys. Res. Commun. 211, 130-136.
2. Bagetta G., Corasaniti M. T., Malorni W., Rainaldi G., Costa N., Berliocchi L., Finazzi-Agrò A. and Nisticò G. (1996) The HIV-1 gp-120 causes ultrastructural changes typical of apoptosis in the rat cerebral cortex. Neuroreport 7, 1722-1724.
3. Bagetta G., Corasaniti M. T., Berliocchi L., Nisticò R., Giammarioli A. M., Malorni W., Aloe E. and Finazzi-Agrò A. (1999) Involvement of interleukin-1β in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp-120-induced apoptosis in the neocortex of rat. Neuroscience 89, 1051-1066.
4. Banks W. A., Kastin A. J. and Akerstrom V. (1997) HIV-1 protein gp-120 crosses the blood-brain barrier: role of adsorptive endocytosis. Life Sci. 61, PL119-125.
5. Budka H. (1991) Neuropathology of human immunodeficiency virus infection. Brain Pathol. 1, 163-175.
6. Buzy J., Brenneman D. E., Pert C. B., Martin A., Salazar A. and Ruff M. R. (1992) Potent gp-120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T. Brain Res. 598, 10-18.
7. Cabrera C., Gutierrez A., Blanco J., Barretina J., Litovchick A., Lapidot A., Evdokimov A. G., Clotet B. and Este J. A. (2000) Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection. AIDS Res. Hum. Retroviruses 16, 627-634.
8. Cabrera C., Gutierrez A., Barretina J., Blanco J., Litovchick A., Lapidot A., Clotet B. and Este J. A. (2002) Anti-HIV activity of a novel aminoglycoside-arginine conjugate. Antiviral. Res. 53, 1-8.
9. Catani M. V., Corasaniti M. T., Navarra M., Nisticò G., Finazzi-Agrò A. and Melino G. (2000) gp-120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors. J. Neurochem. 74, 2373-2379.
10. Clapham P. R. (1997) HIV and chemokines: ligands sharing cell-surface receptors. Trends Cell Biol. 7, 264-268.
11. Corasaniti M. T., Melino G., Navarra M., Garaci E., Finazzi-Agrò A. and Nisticò G. (1995) Death of cultured neuroblastoma cells induced by HIV-1 gp-120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclo-oxygenase. Neurodegeneration 4, 315-321.
12. Corasaniti M. T., Navarra M., Catani M. V., Melino G., Nisticò G. and Finazzi-Agrò A. (1996) NMDA and HIV-1 coat protein, gp-120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain. Biochem. Biophys. Res. Commun. 229, 299-304.
13. Corasaniti M. T., Navarra M., Nisticò S., Rotiroti D., Maccarrone M., Melino G. and Finazzi-Agrò A. (1998) Requirement for membrane lipid peroxidation in HIV-1 gp-120-induced neuroblastoma cell death. Biochem. Biophys. Res. Commun. 246, 686-689.
14. Corasaniti M. T., Turano P., Bilotta A., Malorni W., Stringaro A. R., Nisticò R., Finazzi-Agrò A. and Bagetta G. (2001a) Evidence that increases of mitochondrial immunoreactive IL-1β by HIV-1 gp-120 implicate in situ cleavage of pro-IL-1β in the neocortex of rat. J. Neurochem. 78, 611-618.
15. Corasaniti M. T., Piccirilli S., Paoletti A., Nisticò R., Stringaro A., Malorni W., Finazzi-Agrò A. and Bagetta G. (2001b) Evidence that The HIV-1 coat protein gp-120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor. Neurosci. Lett. 312, 67-70.
16. Dawson V. L., Dawson T. M., Uhl G. R. and Snyder S. H. (1993) Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc. Natl Acad. Sci. USA 90, 3256-3259.
17. Dreyer E. B., Kaiser P. K., Offermann J. T. and Lipton S. A. (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248, 364-367.
18. Everall I. P., Luthert P. J. and Lantos P. L. (1991) Neuronal loss in the frontal cortex in HIV infection. Lancet 337, 1119-1121.
19. Hesselgesser J., Taub D., Baskar P., Greenberg M., Hoxie J., Kolson D. L. and Horuk R. (1998) Neuronal apoptosis induced by HIV-1 gp-120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4. Curr. Biol. 8, 595-598.
20. Huang L., Bosch I., Hofmann W., Sodroski J. and Pardee A. B. (1998) Tat protein induces human immunodeficiency virus type 1 (HIV-1) co-receptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains. J Virol. 72, 8952-8960.
21. Janssen R. S., Cornblath D. R., Epstein L. G., Foa R. P., McArthur J. C. and Price R. W. (1991) Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Neurology 41, 778-785.
22. Jones M. V., Bell J. E. and Nath A. (2000) Immunolocalization of HIV envelope gp-120 in HIV encephalitis with dementia. AIDS 14, 2709-2713.
23. Kaul M., Garden G. A. and Lipton S. A. (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410, 988-994.
24. Lapidot A. and Litovchick A. (2000) Novel HIV-Tat antagonists. Drug. Dev. Res. 50, 502-515.
25. Lapidot A., Litovchick A., Evdokimov A. G. (2000) Patent no. 127773. PCT/IL 99/00704, PCT. International Publication Number WO 00/39139.
26. Lavi E., Kolson D. L., Ulrich A. M., Fu L. and Gonzales-Scarano F. (1998) Chemokine receptors in the human brain and their relationship to HIV infection. J. Neurovirol. 4, 301-311.
27. Lipton S. A., Sucher N. J., Kaiser P. K. and Dreyer E. B. (1991) Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 7, 111-118.
28. Litovchick A., Evdokimov A. G. and Lapidot A. (1999) Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro. FEBS Lett. 445, 73-79.
29. Litovchick A., Evdokimov A. G. and Lapidot A. (2000) Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity. Biochemistry 39, 2838- 2852.
30. Litovchick A., Lapidot A., Eisenstein M., Kalinkovich A. and Borkow G. (2001) Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities. Biochemistry 40, 15612-15623.
31. Meucci O., Fatatis A., Simen A. A., Bushell T. J., Gray P. W. and Miller R. J. (1998) Chemokines regulate hippocampal neuronal signaling and gp-120 neurotoxicity. Proc. Natl Acad. Sci. USA 95, 14500-14505.
32. Petito C. K. and Roberts B. (1995) Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol. 146, 1121-1130.
33. Price R. W., Brew B., Sidtis J., Rosenblum M., Scheck A. C. and Cleary P. (1988) The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239, 586-592.
34. Secchiero P., Zella D., Capitani S., Gallo R. C. and Zauli G. (1999) Extracellular HIV-1 tat protein up-regulates the expression of surface CXC-chemokine receptor 4 in resting CD4+ T cells. J. Immunol. 162, 2427-2431.
35. Toggas S. M., Masliah E., Rockenstein E. M., Rall G. F., Abraham C. R. and Mucke L. (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp-120 in transgenic mice. Nature 367, 188-193.
36. Tyor W. R., Glass J. D., Griffin J. W., Becker S. P., McArthur J. C., Bezman L. and Griffin D. E. (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31, 349-360.
37. Weiss J. M., Nath A., Major E. O. and Berman J. W. (1999) HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and upregulates CCR5 expression on human monocytes. J. Immunol. 163, 2953-2959.
38. Wiley C. A., Masliah E., Morey M., Lemere C., DeTeresa R., Grafe M., Hansen L. and Terry R. (1991) Neocortical damage during HIV infection. Ann. Neurol. 29, 651-657.