B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1

Oncogene

Volumn 29, Issue 12, 2010, Pages 1821-1834

  Yao, Z ^a   Duan, S ^a   Hou, D ^a   Wang, W ^a   Wang, G ^a   Liu, Y ^b   Wen, L ^a   Wu, M ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Apoptosis; B23 NPM; Cell survival; HnRNPs; Nucleolar stress

Indexed keywords

DACTINOMYCIN; DNA DIRECTED RNA POLYMERASE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; NUCLEOPHOSMIN; PROTEIN BCL XL; RIBOSOME RNA; RNA BINDING PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRESS; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOLECULAR DYNAMICS; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REGULATORY MECHANISM; RNA PROCESSING; RNA TRANSCRIPTION; SENSOR;

3' UNTRANSLATED REGIONS; APOPTOSIS; BCL-X PROTEIN; CELL CYCLE; CELL NUCLEOLUS; CELL SURVIVAL; DNA POLYMERASE I; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; NUCLEAR PROTEINS; PROTEIN TRANSPORT; RIBONUCLEASE, PANCREATIC; RIBOSOMES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 77950075202     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.473     Document Type: Article

References (22)

1. Brady SN, Yu Y, Maggi Jr LB, Weber JD. (2004). ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol 24: 9327-9338.
2. Dreyfuss G, Kim VN, Kataoka N. (2002). Messenger-RNA-binding proteins and the messages they carry. Nat Rev 3: 195-205.
3. Dreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG. (1993). hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62: 289-321.
4. Duan S, Yao Z, Hou D, Wu Z, Zhu WG, Wu M. (2007). Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J 26: 3062-3074.
5. Frei IIIrd E. (1974). The clinical use of actinomycin. Cancer Chemother Rep 58: 49-54.
6. Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K et al. (2005). Role of nucleophosmin in embryonic development and tumorigenesis. Nature 437: 147-153.
7. Grisendi S, Mecucci C, Falini B, Pandolfi PP. (2006). Nucleophosmin and cancer. Nat Rev Cancer 6: 493-505.
8. Guil S, Caceres JF. (2007). The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol 14: 591-596.
9. Hingorani K, Szebeni A, Olson MO. (2000). Mapping the functional domains of nucleolar protein B23. J Biol Chem 275: 24451-24457.
10. Iervolino A, Santilli G, Trotta R, Guerzoni C, Cesi V, Bergamaschi A et al. (2002). hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis. Mol Cell Biol 22: 2255-2266.
11. Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G, Fischer U. (1997). A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol 137: 27-35.
12. Johnson RF, McCarthy SE, Godlewski PJ, Harty RN. (2006). Ebola virus VP35-VP40 interaction is sufficient for packaging 3E-5E minigenome RNA into virus-like particles. J Virol 80: 5135-5144.
13. Krecic AM, Swanson MS. (1999). hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 11: 363-371.
14. Kukalev A, Nord Y, Palmberg C, Bergman T, Percipalle P. (2005). Actin and hnRNP U cooperate for productive transcription by RNA polymerase II. Nat Struct Mol Biol 12: 238-244.
15. Mayeda A, Krainer AR. (1992). Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68: 365-375.
16. Okuwaki M. (2008). The structure and functions of NPM1/ nucleophsmin/B23, a multifunctional nucleolar acidic protein. J Biochem 143: 441-448.
17. Perry RP, Kelley DE. (1970). Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. J Cell Physiol 76: 127-139.
18. Takagi M, Absalon MJ, McLure KG, Kastan MB. (2005). Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123: 49-63.
19. Wang W, Budhu A, Forgues M, Wang XW. (2005). Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. Nat Cell Biol 7: 823-830.
20. Wu MH, Chang JH, Chou CC, Yung BY. (2002). Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation. Int J Cancer 97: 297-305.
21. Yugami M, Kabe Y, Yamaguchi Y, Wada T, Handa H. (2007). hnRNP-U enhances the expression of specific genes by stabilizing mRNA. FEBS Lett 581: 1-7.
22. Yung BY, Busch H, Chan PK. (1985). Translocation of nucleolar phosphoprotein B23 (37 kDa/pI 5.1) induced by selective inhibitors of ribosome synthesis. Biochim Biophys Acta 826: 167-173.