Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2639-2644

  Hussein, Ahmed M ^a   Ahmed, Osama M ^a  

^a Beni Suef University   (Egypt)

Author keywords

5 Aminotetrazole; Anti tumor cytotoxicity; Apoptosis; EAC; Formyl salt; HepG2; Tetrazolopyrimidine

Indexed keywords

6,7,8,9 TETRAHYDROTETRAZOLO[1,5 A]QUINAZOLINE; PROTEIN BCL 2; PROTEIN P53; PYRIMIDINE DERIVATIVE; TETRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; EHRLICH ASCITES TUMOR; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONE POT SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, EHRLICH TUMOR; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, BCL-2; GENES, P53; IMMUNOHISTOCHEMISTRY; ISOMERISM; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEOPLASM TRANSPLANTATION; PYRIMIDINES; SPECTROPHOTOMETRY, INFRARED;

EID: 77950039779     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.028     Document Type: Article

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