Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 275-278

  Xie, Fuchun ^a   Zhao, Hongbing ^a   Zhao, Lizhi ^a   Lou, Liguang ^a   Hu, Youhong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Anticancer; BEL 7402; Pyrimidine

Indexed keywords

ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CARCINOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57749089502     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.067     Document Type: Article

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24. 2.Sulforhodamine B cell proliferation assay: Cells were seeded in 96-well plates and then treated with either vehicle (DMSO) or different concentrations of compounds. After 72 h of incubation, cells were fixed with 10% trichloroacetic acid for 1 h at 4 °C, washed five times with tap water and air-dried. Cells were stained with 0.4% (w/v) sulforhodamine B (SRB) for 20 min at room temperature and washed five times with 1% acetic acid. Bound SRB was solubilized with 10 mM Tris and absorbance was measured at 540 nm.