Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2375-2387

  Burja, Bojan ^a   Čimbora Zovko, Tamara ^b   Tomić, Sanja ^b   Jelušić, Tihana ^b   Kočevar, Marijan ^a   Polanc, Slovenko ^a   Osmak, Maja ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Combretastatin CA 4 derivatives; Cytotoxicity; Molecular modeling; Tubulin

Indexed keywords

1,2 DIHYDRO 4 (3,4,5 TRIMETHOXYPHENYL) 5 (4 METHOXYPHENYL)PYRAZOL 3 ONE; 1,2 DIHYDRO 5 (3 HYDROXY 4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL)PYRAZOL 3 ONE; 5 (3 FLUORO 4 METHOXYPHENYL) 1,2 DIHYDRO 4 (3,4,5 TRIMETHOXYPHENYL)PYRAZOL 3 ONE; CISPLATIN; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A4; HYDRAZIDE DERIVATIVE; METHYL 2 [[2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTHALEN 2 YL)]PROP 2 ENOYL]HYDRAZINECARBOXYLATE; PYRAZOLONE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL SHAPE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN TISSUE; IC 50; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR MODEL;

ANTINEOPLASTIC AGENTS; BIBENZYLS; CELL CYCLE; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; CYCLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; HYDROGEN BONDING; INDICATORS AND REAGENTS; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MODELS, MOLECULAR; POLYMERS; PYRAZOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 77950025748     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.006     Document Type: Article

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