Intrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology

Annals of the New York Academy of Sciences

Volumn 1153, Issue , 2009, Pages 89-97

  Renner, Ulrich ^a   De Santana, Eliane Correa ^a   Gerez, Juan ^b   Fröhlich, Bianca ^a   Haedo, Mariana ^b   Pereda, Marcelo Paez ^a,c   Onofri, Chiara ^a   Stalla, Günter K ^a   Arzt, Eduardo ^b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b INSTITUTO DE FISIOLOGÍA   (Argentina)

^c Affectis Pharmaceutical AG   (Germany)

Author keywords

Angiogenesis; Folliculostellate cells; Hormone secretion; Interleukin 6; Lipopolysaccharide; NOD1 NOD2; Pituitary; Pituitary tumors; Proliferation; Toll like receptor 4

Indexed keywords

ANGIOGENIC FACTOR; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CYTOKINE; GLUCOCORTICOID; GLYCOPROTEIN GP 130; GROWTH FACTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTERLEUKIN 6; NEUROPEPTIDE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

ADENOHYPOPHYSIS; BACTERIAL CELL WALL; CARCINOGENESIS; CELL INTERACTION; CELL PROLIFERATION; CONFERENCE PAPER; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; HORMONE RELEASE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; NEUROSECRETORY CELL; NONHUMAN; OVARY FOLLICLE CELL; PATHOPHYSIOLOGY; STELLATE CELL; TUMOR CELL; TUMOR GROWTH;

EID: 60449111282     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03970.x     Document Type: Conference Paper

References (61)

1. Spangelo, B.L. & W.C. Gorospe. 1995. Role of the cytokines in the neuroendocrine-immune system axis. Front. Neuroendocrinol. 16 : 1 22.
2. Besedovsky, H.O. & A. del Rey. 1996. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17 : 64 102.
3. Chrousos, G.P. 1995. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 332 : 1351 1362.
4. Renner, U., J. Gloddek, M.P. Pereda, et al. 1998. Regulation and role of intrapituitary IL-6 production by folliculostellate cells. Domest. Anim. Endocrinol. 15 : 353 362.
5. Arzt, E., M.P. Pereda, C.P. Castro, et al. 1999. Pathophysiological role of the cytokine network in the anterior pituitary gland. Front. Neuroendocrinol. 20 : 71 95.
6. Arzt, E. 2001. gp130 cytokine signalling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways. J. Clin. Invest. 108 : 1729 1733.
7. Graciarena, M., A. Carbia-Nagashima, C. Perez-Castro, et al. 2003. Pituitary gp130 cytokine networks. In Pituitary and Periphery: Communication In and Out. C.J. Strasburger, Ed. : 197 210. BioScientifica Ltd. Bristol, UK.
8. Vlotides, G., K. Zitzmann, S. Hengge, et al. 2004. Expression of novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) in murine pituitary folliculostellate TtT/GF cells: pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-induced stimulation of NNT-1/BSF-3 is mediated by protein kinase A, protein kinase C, and extracellular-signal- regulated kinase 1/2 pathways. Endocrinology 145 : 716 727.
9. Hanisch, A., K.D. Dieterich, K. Dietzmann, et al. 2000. Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas. J. Clin. Endocrinol. Metab. 85 : 4411 4414.
10. Perez Castro, C., A.C. Nagashima, M.P. Pereda, et al. 2000. The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines. Endocrinology 141 : 1746 1753.
11. Perez Castro, C., A. Carbia Nagashima, M. Paez Pereda, et al. 2001. Effects of the gp130 cytokines ciliary neurotropic factor (CNTF) and interleukin-11 on pituitary cells: CNTF receptors on human pituitary adenomas and stimulation of prolactin and GH secretion in normal rat anterior pituitary aggregate cultures. J. Endocrinol. 169 : 539 547.
12. Auernammer, C.J. & S. Melmed. 1999. Leukemia inhibitory factor - neuroimmune modulator of endocrine function. Endocr. Rev. 21 : 313 345.
13. Kontogeorgos, G., H. Patralexis, A. Tran, et al. 2000. Expression of leukemia inhibitory factor in human pituitary adenomas: a morphologic and immunocytochemical study. Pituitary 2 : 245 251.
14. Yano, H., C. Readhead, M. Nakashima, et al. 1998. Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: neuro-immune-endocrine modulation of pituitary development. Mol. Endocrinol. 12 : 1708 1720.
15. Ben-Shlomo, A., I. Miklovsky, S.-G. Ren, et al. 2003. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J. Clin. Endocrinol. Metab. 88 : 858 863.
16. Rinehart, J.F. & M.G. Farquhar. 1953. Electron microscopic studies of the anterior pituitary gland. J. Histochem. Cytochem. 1 : 93 113
17. Inoue, K., E.F. Couch, K. Takano, et al. 1999. The structure and function of folliculo-stellate cells in the anterior pituitary gland. Archiv. Histol. Cytol. 62 : 205 218.
18. Allaerts, W. & H. Vankelecom. 2005. History and perspectives of pituitary folliculo-stellate cell research. Eur. J. Endocrinol. 153 : 1 12.
19. Fauquier, T., N.C. Guerineau, R.A. McKinney, et al. 2001. Folliculostellate cell network: a route for long-distance communication in the anterior pituitary. Proc. Natl. Acad. Sci. USA 98 : 8891 8896.
20. Fauquier, T., A. Lacampagne, P. Travo, et al. 2002. Hidden face of the anterior pituitary. Trends Endocrinol. Metab. 13 : 304 309.
21. Morand, I., P. Fonlupt, A. Guerrier, et al. 1996. Cell-to-cell communication in the anterior pituitary: evidence for gap junctions-mediated exchanges between endocrine cells and folliculostellate cells. Endocrinology 137 : 3356 3367.
22. Lewis, B.M., A. Pexa, K. Francis, et al. 2006. Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells. FASEB J. 20 : 2585 2587.
23. Meilleur, M.A., C.D. Akpovi, R.M. Pelletier, et al. 2007. Tumor necrosis factor-alpha-induced anterior pituitary folliculostellate TtT/GF cell uncoupling is mediated by connexin 43 dephosphorylation. Endocrinology 148 : 5913 5924.
24. Aoki, A., E.O. de Gaisan, H.A. Pasolli, et al. 1996. Disposal of cell debris from surplus lactotrophs of pituitary gland. Exp. Clin. Endocrinol. Diabetes 104 : 256 262.
25. Allaerts, W., P.H.M. Jeucken, R. Debets, et al. 1997. Heterogeneity of pituitary folliculo-stellate cells: implications for IL-6 production and accessory function in vitro. J. Neuroendocrinol. 9 : 43 53.
26. Fauquier, T., K. Rizzoti, M. Dattani, et al. 2008. SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc. Natl. Acad. Sci. USA 105 : 2907 2912.
27. Vankelecom, H., P. Carmeliet, J. Van Damme, et al. 1989. Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 49 : 102 106.
28. Vankelecom, H., P. Matthys, J. Van Damme, et al. 1993. Immunocytochemical evidence that S-100 positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity. J. Histochem. Cytochem. 41 : 151 156.
29. Prummel, M.F., L.J.S. Brokken, G. Meduri, et al. 2000. Expression of the thyroid-stimulating hormone receptor in the folliculo-stellate cells of the human anterior pituitary. J. Clin. Endocrinol. Metab. 85 : 4347 4353.
30. Herkenham, M. 2005. Folliculo-stellate (FS) cells of the anterior pituitary mediate interactions between the endocrine and immune systems. Endocrinology 146 : 33 34.
31. Ueta, Y., A. Levy, H.S. Chowdrey, et al. 1995. S-100 antigen-positive folliculostellate cells are not the source of IL-6 gene expression in human pituitary adenomas. J. Neuroendocrinol. 7 : 467 474.
32. Marin, F., K. Kovacs, L. Stefaneanu, et al. 1992. S-100 protein immunopositivity in human nontumorous hypophyses and pituitary adenomas. Endocr. Pathol. 3 : 28 38.
33. Jones, T.H., M. Daniels, R.A. James, et al. 1994. Production of bioactive and immunoreactive interleukin-6 (IL-6) and expression of IL-6 messenger ribonucleic acid by human pituitary adenomas. J. Clin. Endocrinol. Metab. 78 : 180 187.
34. Borg, S.A., K.E. Kerry, L. Baxter, et al. 2003. Expression of interleukin-6 and its effect on growth of HP75 human pituitary tumor cells. J. Clin. Endocrinol. Metab. 88 : 4938 4944.
35. Roncaroli, F., B.W. Scheithauer, G. Cenacchi, et al. 2002. "Spindle cell oncocytoma" of the adenohypophysis: a tumor of folliculostellate cells? Am. J. Surg. Pathol. 26 : 1048 1055.
36. Höfler, H., G.F. Walter & H. Denk. 1984. Immunohistochemistry of folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas. Acta Neuropathol. 65 : 35 40.
37. Yamashita, M., Z.R. Quia, T. Sano, et al. 2005. Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis. Pathol. Int. 55 : 244 247.
38. Farnoud, M.R., M. Kujas, P. Derome, et al. 1994. Interactions between normal and tumoral tissues at the boundary of human pituitary adenomas. Virch. Arch. 424 : 75 82.
39. Inoue, K., H. Matsumoto, C. Koyama, et al. 1992. Establishment of a folliculostellate-like cell line from a murine thyrotropic pituitary tumor. Endocrinology 131 : 3110 3116.
40. Carbia Nagashima, A., D. Giacomini, C. Perez Castro, et al. 2003. Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Mol. Cell. Endocrinol. 201 : 47 56.
41. Lohrer, P., J. Gloddek, A.C. Nagashima, et al. 2000. Lipopolysaccharide directly stimulates the intrapituitary interleukin-6 production by folliculostellate cells via specific receptors and the p38alpha mitogen-activated protein kinase/nuclear factor-kappaB pathway. Endocrinology 141 : 4457 4465.
42. Akira, S., K. Takeda & T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2 : 675 680.
43. Gloddek, J., P. Lohrer, J. Stalla, et al. 2001. The intrapituitary stimulatory effect of lipopolysaccharide on ACTH secretion is mediated by paracrine-acting IL-6. Exp. Clin. Endocrinol. Diabetes 109 : 410 415.
44. Correa-de-Santana, E., M. Theodoropoulou, M. Paez-Pereda, et al. 2007. Expression and functionality of NOD molecules in the adenopituitary folliculostellate cells. Exp. Clin. Endocrinol. Diabetes 115 : 548.
45. Fritz, J.H., R.L. Ferrero, D.J. Philpott, et al. 2006. Nod-like proteins in immunity, inflammation and disease. Nat. Immunol. 7 : 1250 1257.
46. Thiele, J.-O., P. Lohrer, L. Schaaf, et al. 2003. Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas. Eur. J. Endocrinol. 149 : 455 461.
47. Paez Pereda, M., P. Lohrer, D. Kovalovsky, et al. 2000. Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Exp. Clin. Endocrinol. Diabetes 108 : 202 207.
48. Onofri, C., A. Carbia Nagashima, L. Schaaf, et al. 2004. Estradiol stimulates vascular endothelial growth factor and interleukin-6 in human lactotroph and lactosomatotroph pituitary adenomas. Exp. Clin. Endocrinol. Diabetes 112 : 18 23.
49. Asa, S.L. & S. Ezzat. 1998. The cytogenesis and pathogenesis of pituitary adenomas. Endocr. Rev. 19 : 798 827.
50. Tichomirowa, M., M. Theodoropoulou, P. Lohrer, et al. 2005. Bacterial endotoxin (lipopolysaccharide) stimulates interleukin-6 production and inhibits growth of pituitary tumour cells expressing the Toll-like receptor 4. J. Neuroendocrinol. 17 : 152 160.
51. Arzt, E., R. Buric, G. Stelzer, et al. 1993. Interleukin involvement in anterior pituitary cell growth regulation: effects of interleukin-2 (IL-2) and IL-6. Endocrinology 132 : 459 467.
52. Gloddek, J., U. Pagotto, M. Paez Pereda, et al. 1999. Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. J. Endocrinol. 160 : 483 490.
53. Lohrer, P., J. Gloddek, U. Hopfner, et al. 2001. Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro. Neuroendocrinology 74 : 95 105.
54. Ferrara, N. 2004. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25 : 581 611.
55. Gomariz, R.P., Y. Juarranz, C. Abad, et al. 2006. VIP-PACAP system in immunity: new insights for multitarget therapy. Ann. N. Y. Acad. Sci. 1070 : 51 74.
56. Sawada, T., K. Koike, Y. Kanda, et al. 1995. IL-6 stimulates cell proliferation of rat anterior pituitary clonal cell lines in vitro. J. Endocrinol. Invest. 18 : 83 90.
57. Paez Pereda, M., V. Goldberg, A. Chervin, et al. 1996. Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. Mol. Cell. Endocrinol. 124 : 33 42.
58. Koyama, C., H. Matsumoto, T. Sakai, et al. 1995. Pituitary folliculo-stellate-like cells stimulate somatotropic pituitary growth in nude mice. Endocr. Pathol. 6 : 67 75.
59. Castro, C.P., D. Giacomini, A.C. Nagashima, et al. 2003. Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development in pituitary lactosomatotrophic GH3 cells. Endocrinology 144 : 693 700.
60. Graciarena, M., A. Carbia-Nagashima, C. Onofri, et al. 2004. Involvement of the gp130 cytokine transducer in MtT/S somatotroph tumour development in an autocrine-paracrine model. Eur. J. Endocrinol. 151 : 595 604.
61. Carbia-Nagashima, A., J. Gerez, C. Perez-Castro, et al. 2007. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1a during hypoxia. Cell 131 : 309 323.