Pattern and localisation of expression of vascular endothelial growth factor and its receptor flt-1 in the ovine pituitary gland: Expression is independent of hypothalamic control

Molecular and Cellular Endocrinology

Volumn 134, Issue 2, 1997, Pages 91-100

  Jabbour, H N ^a   Boddy, S C ^a   Lincoln, G A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anterior pituitary; Flt 1; Hypothalamo pituitary disconnection; Pars tuberalis; Sheep; VEGF; Zona tuberalis

Indexed keywords

DIMER; GROWTH FACTOR RECEPTOR; HORMONE ANTIBODY; LUTEINIZING HORMONE; LUTEINIZING HORMONE ANTIBODY; PROLACTIN; PROTEIN ANTIBODY; RECEPTOR ANTIBODY; VASCULOTROPIN;

ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD VESSEL PERMEABILITY; GENE EXPRESSION; HORMONE RELEASE; HYPOPHYSIS; HYPOPHYSIS INTERMEDIATE LOBE; HYPOPHYSIS PARS TUBERALIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEEP; SOUTHERN BLOTTING;

ANIMALS; ENDOTHELIAL GROWTH FACTORS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LYMPHOKINES; MALE; PITUITARY GLAND, ANTERIOR; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0030853173     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00158-5     Document Type: Article

References (46)

1. Allaerts W., Denef C. Regulatory activity and topological distribution of folliculo-stellate cells in rat anterior pituitary cell aggregates. Neuroendocrinology. 49:1989;409.
2. Allaerts W., Carmeliet P., Denef C. New perspective in the function of pituitary folliculo-stellate cells. Mol. Cell. Endocrinol. 71:1990;73-81.
3. Alroy J., Goyal V., Skutelsky E. Lectin histochemistry of mammalian endothelium. Histochemistry. 86:1987;603-607.
4. Baes M., Allaerts W., Denef C. Evidence for functional communication between folliculo-stellate cells and hormone-secreting cells in perifused anterior pituitary cell aggregates. Endocrinology. 120:1987;685-691.
5. Cagnacci A., Elliott J.A., Yen S.S.C. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J. Clin. Endocrinol. Metab. 75:1992;447-452.
6. Casely-Smith J.R. The functioning of endothelial fenestrae on the arterial and venous limbs of capillaries, as indicated by the differing directions of passage of proteins. Experientia. 26:1970;852-853.
7. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
8. Christofori G., Naik P., Hanahan D. Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol. Endocrinol. 9:1995;1760-1770.
9. Clark D.E., Smith S.K., Sharkey A.M., Charnock-Jones D.S. Localisation of VEGF and expression of its receptor flt and KDR in human placenta throughout pregnancy. Hum. Reprod. 11:1996;1090-1098.
10. Clarke I.J., Cummins J.T., de Kretser D.M. Pituitary gland function after disconnection from direct hypothalamic influences in sheep. Neuroendocrinology. 36:1983;376-384.
11. Clements F., Palade G.E. Intestinal capillaries I. Permeability to peroxidase and ferritin. J. Cell Biol. 41:1969;33-58.
12. Connolly D.T., Heuvelman D.M., Nelson R., Olander J.V., Eppley B.L., Delfino J.J., Siegel N.R., Leimgruber R.M., Feder J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 84:1989;1470-1478.
13. Dawson A.B. The relationship of the pars tuberalis to pars distalis in the hypophysis of the rhesus monkey. Anat. Rec. 102:1948;103-121.
14. De Jong A.S.H., Van Kessel-Van Vark M., Raap A.K. Sensitivity of various visualisation methods for peroxidase and alkaline phosphatase activity in immunoenzyme histochemistry. Histochem. J. 17:1985;1119-1130.
15. de Vries C., Escobedo J.A., Ueno H., Houck K., Ferrara N., Williams L.T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 255:1992;989-991.
16. Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am. J. Path. 146:1995;1029-1039.
17. Farquhar M.G., Palade G.E. Junctional complexes in various epithelia. J. Cell Biol. 17:1963;375-412.
18. Ferrara N., Henzel W.J. Pituitary follicular stellate cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161:1989;851.
19. Ferrara N., Houck K., Jakeman L., Leung D.W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr. Rev. 13:1992;18-32.
20. Fong G.-H., Rossant J., Gertsenstein M., Breitman M.L. Role of the flt-1 receptor tyrosine kinase in regulating the assembly of the vascular endothelium. Nature. 376:1995;66-70.
21. Gordon J.D., Mesiano S., Zaloudek C.J., Jaffe R.B. Vascular endothelial growth factor localisation in human ovary and fallopian tubes: Possible role in reproductive function and ovarian cyst formation. J. Clin. Endocrinol. Metab. 81:1996;353-359.
22. Jabbour H.N., Clarke L.A., Boddy S., Pezet A., Edery M., Kelly P.A. Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates β-casein promoter activation. Mol. Cell. Endocrinol. 123:1996;17-26.
23. Jakeman L.B., Altar C.A., Winer J., Bennett G.L., Ferrara N. Binding sites for vascular endothelial growth factor are localised on endothelial cells in adult rat tissues. J. Clin. Invest. 89:1992;244-253.
24. Keck P.J., Hauser S.D., Krivi G., Sanzo K., Warren T., Feder J., Connolly D.T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 246:1989;1309-1312.
25. Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1989;1306-1309.
26. Levidiotis M., Perry R.A., Wintour E.M., Oldfield B.J. Analysis of the appearance of fenestrations in the blood vessels of the fetal sheep pituitary. Neuroendocrinology. 53:1991;222-228.
27. Lincoln G.A., Clarke I.J. Evidence that melatonin acts in the pituitary gland through a dopamine independent mechanism to mediate effects of daylength on the secretion of prolactin in the ram. J. Neuroendocrinol. 7:1995;637-643.
28. Lincoln G.A., Clarke I.J., Sweeney T. Hamster-like cycles in testicular size in the absence of gonadotrophin secretion in HPD rams exposed to long-term changes in photoperiod and treatment with melatonin. J. Neuroendocrinol. 8:1996;855-866.
29. Page R.B. Pituitary blood-flow. Am. J. Physiol. 243:1982;E427-E442.
30. Perryman E.K. Folliculo-stellate cells of the pituitary gland. Bioscience. 39:1989;81-88.
31. Redmer D.A., Dai Y., Li J., Charnock-Jones D.S., Smith S.K., Reynolds L.P., Moor R.M. Characterisation and expression of vascular endothelial growth factor (VEGF) in the ovine corpus luteum. J. Reprod. Fertil. 108:1996;157-165.
32. Reppert S.M., Weaver D.R., Ebisawa T. Cloning and characterisation of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 13:1994;117-118.
33. Schwartz J., Cherny R. Intercellular communication within the anterior pituitary influencing the secretion of hypophysial hormones. Endocr. Rev. 13:1992;453-475.
34. Senger D.R., Van de Water L., Brown L.F., Nagy J.A., Yeo K.T., Berse B., Jackman R.W., Dvorak A.M., Dvorak H.F. Vascular permeability factor (VPF VEGF) in tumor biology. Cancer Metastasis Rev. 12:1993;303-324.
35. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.-F., Breitman M.L., Schuh A. Failure of blood-island formation and vasculogenesis in flk-1-deficient mice. Nature. 376:1995;62-66.
36. Skinner D.C., Robinson J.E. Melatonin-binding sites in the gonadotroph-enriched zona tuberalis of ewes. J. Reprod. Fertil. 104:1995;243-250.
37. Svalander C. Ultrastructure of the fetal rat adenohypophysis. Acta Endocrinol. Suppl. 188:1974;1-114.
38. Terman B.I., Dougher-Vermazen M., Carrion M.E., Dimitrov D., Armellino D.C., Gospodarowicz D., Bohlen P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem. Biophys. Res. Commun. 187:1992;1579-1586.
39. Thomas G.B., McNeilly A.S., Brooks A.N. Development of gonadotrophs and thyrotrophs in the female foetal sheep pituitary: Immunocytochemical localisation studies. J. Neuroendocrinol. 5:1993;157-161.
40. Waltenberger J., Claesson-Welsh L., Siegbahn A., Shibuya M., Heldin C.-H. Different signal transduction properties of KDR and flt-1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269:1994;26988-26995.
41. Wang W., Merrill M.J., Borchardt R.T. Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. Am. J. Physiol. 40:1996;C1973-C1980.
42. Weaver D.R., Reppert S.M. Melatonin receptors are present in the ferret pars tuberalis and pars distalis, but not in the brain. Endocrinology. 127:1990;2607-2609.
43. Williams, L.M., Lincoln, G.A., Mercer, J.G., Barrett, P., Morgan, P.J. and Clarke, I.J., 1997 Melatonin receptors in the brain and pituitary gland of hypothalamo-pituitary disconnected soay rams. J. Neuroendocrinol. 9, 639-643.
44. Wittkowski W.H., Schulze-Bonhage A.H., Bockers T.M. The pars tuberalis of the hypophysis: a modulator of the pars distalis? Acta Endocrinol. 126:1992;285-290.
45. Yuan F., Chen Y., Dellian M., Safabakhsh N., Ferrara N., Jain R.K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an antivascular endothelial growth-factor vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA. 93:1996;14765-14770.
46. Zanoboni A., Zanoboni W. Experimental hypertension in pinealectomised rats. Life Sci. 6:1967;2327-2331.