Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome

Fertility and Sterility

Volumn 93, Issue 6, 2010, Pages 1948-1956

  Rocha, Michelle P ^a   Maranhão, Raul C ^a   Seydell, Talita M ^a   Barcellos, Cristiano R G ^a   Baracat, Edmundo C ^a   Hayashida, Sylvia A Y ^a   Bydlowski, Sérgio P ^a   Marcondes, José A M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

atherosclerosis; insulin resistance; Polycystic ovary syndrome; transfer lipoproteins; triglyceride rich lipoprotein remnants

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CARBON 14; CHOLESTEROL ESTER; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRIACYLGLYCEROL; TRITIUM;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; EMULSION; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INCUBATION TIME; INSULIN RESISTANCE; ISOTOPE LABELING; LIPID METABOLISM; LIPID TRANSPORT; LIPOLYSIS; LIPOPROTEIN BLOOD LEVEL; NANOEMULSION; OBESITY; OVARY POLYCYSTIC DISEASE; PHOSPHOLIPID BLOOD LEVEL; PRECIPITATION; PRIORITY JOURNAL; SUPERNATANT; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGE FACTORS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; FAT EMULSIONS, INTRAVENOUS; FEMALE; HUMANS; IDEAL BODY WEIGHT; INSULIN RESISTANCE; LIPID METABOLISM; LIPOPROTEINS, HDL; LUTEINIZING HORMONE; MATCHED-PAIR ANALYSIS; OBESITY; POLYCYSTIC OVARY SYNDROME; TRIGLYCERIDES; YOUNG ADULT;

EID: 77949914294     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.12.044     Document Type: Article

References (37)

1. Ehrmann D.A. Polycystic ovary syndrome. N Engl J Med 352 (2005) 1223-1236
2. The Rotterdam ESHRE/ASRM-sponred PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
3. Guzick D.S. Polycystic ovary syndrome. Obstet Gynecol 103:181-93. Dunaif A: Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endoc Rev 18 (1997) 774-800
4. Barcellos C.R., Rocha M.P., Hayashida S.A., Nery M., and Marcondes J.A. Prevalence of abnormalities of glucose metabolism in patients with polycystic ovary syndrome. Arq Bras Endocrinol Metabol 51 (2007) 601-605
5. Legro R.S., Kunselman A.R., Dodson W.C., and Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84 (1999) 165-169
6. Dahlgren E., Johansson S., Lindstedt G., Knutsson F., Odén A., Janson P.O., et al. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 57 (1992) 505-513
7. Lakhani K., Hardiman P., and Seifalian A.M. Intima-media thickness of elastic and muscular arteries of young women with polycystic ovaries. Atherosclerosis 175 (2004) 353-359
8. Legro R.S., Kunselman A.R., and Dunaif A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 111 (2001) 607-613
9. Berneis K., Rizzo M., Lazzarini V., Fruzzetti F., and Carmina E. Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome. J Clin Endocrinol Metab 92 (2007) 186-189
10. Dejager S., Pichard C., Giral P., Bruckert E., Federspield M.C., Beucler I., et al. Smaller LDL particle size in women with polycystic ovary syndrome compared with controls. Clin Endocrinol (Oxf) 54 (2001) 455-462
11. Velazquez M.E., Bellabarba G.A., Mendoza S., and Sanchez L. Postprandial triglyceride response in patients with polycystic ovary syndrome: relationship with wais-to-hip ratio and insulin. Fertil Steril 74 (2000) 1159-1163
12. Groot P.H., van Stiphout W.A., Krauss X.H., Jansen H., van Tol A., van Ramshorst E., et al. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arteroscler Thromb 11 (1991) 653-662
13. Karpe F., and Hamsten A. Postprandial lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 6 (1995) 123-129
14. Maranhão R.C., Feres M.C., Martins M.T., Mesquita C.H., Toffoletto O., Vinagre C.G., et al. Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease. Atherosclerosis 126 (1996) 15-21
15. Sposito A.C., Ventura L.I., Vinagre C.G., Lemos P.A., Quintela E., Santos R.D., et al. Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease. Atherosclerosis 176 (2004) 397-403
16. Redgrave T.G., and Maranhão R.C. Metabolism of protein-free lipid emulsion models of chylomicrons in rats. Biochim Biophys Acta 835 (1985) 104-110
17. Kontush A., and Chapman M.J. Antiatherogenic small, dense HDL-guardian angel of the arterial wall?. Nat Clin Pract Cardiovasc Med 3 (2006) 144-153
18. Vermeulen A., Verdonck L., and Kaufman J.M. A critical evaluation of simple methods for the estimation of testosterone in serum. J Clin Endocrinol Metab 84 (1999) 3666-3672
19. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
20. Chen M.J., Yang W.S., Yang J.H., Hsiao C.K., Yang y., and Ho H.N. Low sex hormone- binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS. Hum Reprod 21 (2006) 2266-2271
21. Holte J., Bergh T., Berne C., and Lithell H. Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin Endocrinol (Oxf) 41 (1994) 463-471
22. Conway R.S., Agrawal R., Betteridge D.J., and Jacobs H.S. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol (Oxf) 37 (1992) 119-125
23. Robinson S., Henderson D., Gelding S.V., Kiddy D., Niththyananthan R., Bush A., et al. Dyslipidaemia is associated with insulin resistance in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 44 (1996) 277-284
24. Krasinski S.D., Cohn J.S., Schaefer E.J., and Russell R.M. Postprandial plasma retinyl ester response is greater in older subjects compared with younger subjects. Evidence for delayed plasma clearance of intestinal lipoproteins. J Clin Invest 85 (1990) 883-892
25. Diamanti-Kandarakis E., and Papavassiliou A.G. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med 12 (2006) 324-332
26. Nestler J.E. Metformin for the treatment of the polycystic ovary syndrome. N Engl J Med 358 (2008) 47-54
27. Borggreve S.E., De Vries R., and Dullaart R.P. Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin: cholesterol acyltransferase and lipid transfer proteins. Eur J Clin Invest 33 (2003) 1051-1069
28. Lithell H., Nillius S.J., Bergh T., and Selious I. Metabolic profile in obese women with the polycystic ovary syndrome. Int J Obes 11 (1987) 1-8
29. Allister E.M., James A.P., Watts G.F., Barrett P.H., and Mamo J.C. Effect of an acute hyperinsulinaemic clamp on post-prandial lipaemia in subjects with insulin resistance. Eur J Clin Invest 36 (2006) 489-496
30. Sposito A.C., Lemos P.A., Santos R.D., Hueb W., Vinagre C.G., Quintella E., et al. Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: a long-term follow-up study. J Am Coll Cardiol 43 (2004) 2225-2232
31. Wilhelm M.G., and Cooper A.D. Induction of atherosclerosis by human chylomicron remnants: a hypothesis. J Atheroscler Thromb 10 (2003) 132-139
32. Oliveira M.R., and Maranhão R.C. Plasma kinectics of a chylomicron-like emulsion in normolipidemic obese women after a short-period weight loss energy-restricted diet. Metabolism 51 (2002) 1097-1103
33. Avramoglu R.K., Basciano H., and Adeli K. Lipid and lipoprotein dysregulation in insulin resistant states. Clin Chim Acta 368 (2006) 1-19
34. Corbould A. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. J Clin Endocrinol Metab 192 (2007) 585-594
35. Santos R.D., Ventura L.I., Sposito A.C., Schreiber R., Ramires J.A., and Maranhão R.C. The effects of gemfibrozil upon the metabolism of chylomicron-like emulsions in patients with endogenous hypertriglyceridemia. Cardiovasc Res 49 (2001) 456-465
36. Sposito A.C., Maranhão R.C., Vinagre C.G., Santos R.D., and Ramires J.A. Effects of etofibrate upon the metabolism of chylomicron-like emulsions in patients with coronary artery disease. Atherosclerosis 154 (2001) 455-461
37. Sposito A.C., Santos R.D., Amancio R.F., Ramires J.A., Chapman M.J., and Maranhão R.C. Atorvastatin enhances the plasma clearance of chylomicron-like emulsions in subjects with atherogenic dyslipidemia: relevance to the in vivo metabolism of triglyceride-rich lipoproteins. Atherosclerosis 166 (2003) 311-321