The inhibition in tumor necrosis factor-α-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-κB and reactive oxygen species

Journal of Thrombosis and Thrombolysis

Volumn 29, Issue 1, 2010, Pages 52-59

  Lin, Pen Yuan ^a   Shen, Hsi Che ^b,c   Chen, Chien Jen ^d   Wu, Shu En ^d   Kao, Hsien Li ^e   Huang, Jen Hung ^f   Wang, Danny Ling ^d   Chen, Shih Chung ^f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c Taipei County Hospital   (Taiwan)

^d INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Carvedilol; Endothelial cell; Reactive oxygen species; Thrombomodulin; Tumor necrosis factor

Indexed keywords

CARVEDILOL; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTICOAGULATION; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; COW; DOWN REGULATION; ENDOTHELIUM CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; UPREGULATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARBAZOLES; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; NF-KAPPA B; PROPANOLAMINES; REACTIVE OXYGEN SPECIES; THROMBOMODULIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77949913053     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-009-0318-2     Document Type: Article

References (42)

1. M Rauchhaus W Doehner DP Francis C Davos M Kemp C Liebenthal J Niebauer J Hooper HD Volk AJ Coats SD Anker 2000 Plasma cytokine parameters and mortality in patients with chronic heart failure Circulation 102 3060 3067 1:CAS:528:DC%2BD3MXitlSltg%3D%3D 11120695
2. T Tsutamoto T Hisanaga A Wada K Maeda M Ohnishi D Fukai N Mabuchi M Sawaki M Kinoshita 1998 Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure J Am Coll Cardiol 31 391 398 10.1016/S0735-1097(97)00494-4 10.1016/S0735-1097(97)00494-4 1:STN:280:DyaK1c7it1CitA%3D%3D 9462584 (Pubitemid 28153460)
3. M Testa M Yeh P Lee R Fanelli F Loperfido JW Berman TH LeJemtel 1996 Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension J Am Coll Cardiol 28 964 971 10.1016/S0735-1097(96)00268-9 10.1016/S0735-1097(96)00268-9 1:STN:280:DyaK28vjsVKmsw%3D%3D 8837575 (Pubitemid 26348163)
4. G Torre-Amione S Kapadia C Benedict H Oral JB Young DL Mann 1996 Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD) J Am Coll Cardiol 27 1201 1206 10.1016/0735-1097(95)00589-7 10.1016/0735-1097(95)00589-7 1:STN:280:DyaK287osFymsg%3D%3D 8609343 (Pubitemid 26117714)
5. A Deswal NJ Petersen AM Feldman JB Young BG White DL Mann 2001 Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the vesnarinone trial (VEST) Circulation 103 2055 2059 1:CAS:528:DC%2BD3MXjvVarsbo%3D 11319194
6. T Yokoyama L Vaca RD Rossen W Durante P Hazarika DL Mann 1993 Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart J Clin Invest 92 2303 2312 10.1172/JCI116834 10.1172/JCI116834 1:CAS:528:DyaK2cXivFSltw%3D%3D 8227345
7. DL Mann 2002 Inflammatory mediators and the failing heart: past, present, and the foreseeable future Circ Res 91 988 998 10.1161/01.RES.0000043825.01705. 1B 10.1161/01.RES.0000043825.01705.1B 1:CAS:528:DC%2BD38XoslOqt7o%3D 12456484 (Pubitemid 35416635)
8. LA Madge JS Pober 2001 TNF signaling in vascular endothelial cells Exp Mol Pathol 70 317 325 10.1006/exmp.2001.2368 10.1006/exmp.2001.2368 1:CAS:528:DC%2BD3MXksV2ksro%3D 11418010 (Pubitemid 32607204)
9. DG Harrison 1997 Cellular and molecular mechanisms of endothelial cell dysfunction J Clin Invest 100 2153 2157 10.1172/JCI119751 10.1172/JCI119751 1:CAS:528:DyaK2sXnt1Ggs74%3D 9410891
10. AJ Nichols AC Sulpizio DJ Ashton JP Hieble RR Ruffolo Jr 1989 In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol Pharmacology 39 327 336 10.1159/000138616 10.1159/000138616 1:CAS:528:DyaK3cXjtVeqtA%3D%3D 2575762
11. M Packer AJ Coats MB Fowler HA Katus H Krum P Mohacsi JL Rouleau M Tendera A Castaigne EB Roecker, et al. 2001 Effect of carvedilol on survival in severe chronic heart failure N Engl J Med 344 1651 1658 10.1056/ NEJM200105313442201 10.1056/NEJM200105313442201 1:CAS:528:DC%2BD3MXkslWjt7c%3D 11386263 (Pubitemid 32479962)
12. G Cinquegrana L D'Aniello M Landi L Spinelli G Grande F De Prisco M Petretta 2005 Effects of different degrees of sympathetic antagonism on cytokine network in patients with ischemic dilated cardiomyopathy J Card Fail 11 213 219 10.1016/j.cardfail.2004.07.006 10.1016/j.cardfail.2004.07.006 1:CAS:528:DC%2BD2MXivV2isb0%3D 15812750 (Pubitemid 40462425)
13. SA Fahlbusch D Tsikas C Mehls FM Gutzki RH Boger JC Frolich DO Stichtenoth 2004 Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers Eur J Clin Pharmacol 60 83 88 10.1007/s00228-004- 0729-0 10.1007/s00228-004-0729-0 1:CAS:528:DC%2BD2cXjtFyit78%3D 15004731 (Pubitemid 38656126)
14. ML Kukin J Kalman RH Charney DK Levy C Buchholz-Varley ON Ocampo C Eng 1999 Prospective, randomized comparison of effect of long-term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction, and oxidative stress in heart failure Circulation 99 2645 2651 1:CAS:528:DyaK1MXjvVKmtr0%3D 10338457
15. PG Lysko CL Webb JL Gu EH Ohlstein RR Ruffolo Jr TL Yue 2000 A comparison of carvedilol and metoprolol antioxidant activities in vitro J Cardiovasc Pharmacol 36 277 281 10.1097/00005344-200008000-00020 10.1097/00005344- 200008000-00020 1:CAS:528:DC%2BD3cXls1yrsb4%3D 10942172
16. K Nakamura K Kusano Y Nakamura M Kakishita K Ohta S Nagase M Yamamoto K Miyaji H Saito H Morita, et al. 2002 Carvedilol decreases elevated oxidative stress in human failing myocardium Circulation 105 2867 2871 10.1161/01.CIR.0000018605.14470.DD 10.1161/01.CIR.0000018605.14470.DD 1:CAS:528:DC%2BD38Xls1aku70%3D 12070115 (Pubitemid 34666100)
17. Z Yuan K Shioji Y Kihara H Takenaka Y Onozawa C Kishimoto 2004 Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property Am J Physiol Heart Circ Physiol 286 H83 H90 10.1152/ajpheart.00536.2003 10.1152/ajpheart. 00536.2003 1:CAS:528:DC%2BD2cXotF2rtg%3D%3D 14684360
18. TL Yue PJ McKenna JL Gu HY Cheng RE Ruffolo Jr GZ Feuerstein 1994 Carvedilol, a new vasodilating beta adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils Cardiovasc Res 28 400 406 10.1093/cvr/28.3.400 10.1093/cvr/28.3.400 1:CAS:528:DyaK2cXkvF2gu7w%3D 7909721
19. WH Frishman 1998 Carvedilol N Engl J Med 339 1759 1765 10.1056/NEJM199812103392407 10.1056/NEJM199812103392407 1:STN:280: DyaK1M%2FkvFyqsg%3D%3D 9845712 (Pubitemid 28555436)
20. TL Yue PJ McKenna PG Lysko JL Gu KA Lysko RR Ruffolo Jr GZ Feuerstein 1994 SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant Eur J Pharmacol 251 237 243 10.1016/0014-2999(94)90405-7 10.1016/0014-2999(94)90405-7 1:CAS:528:DyaK2cXitlGks7Y%3D 8149979
21. OI Aruoma 1997 Scavenging of hypochlorous acid by carvedilol and ebselen in vitro Gen Pharmacol 28 269 272 10.1016/S0306-3623(96)00232-7 1:CAS:528:DyaK2sXisVCitA%3D%3D 9013206 (Pubitemid 27016137)
22. PA Poole-Wilson K Swedberg JG Cleland A Di Lenarda P Hanrath M Komajda J Lubsen B Lutiger M Metra WJ Remme, et al. 2003 Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the carvedilol or metoprolol european trial (COMET): randomised controlled trial Lancet 362 7 13 10.1016/S0140-6736(03)13800-7 10.1016/S0140-6736(03)13800-7 1:CAS:528:DC%2BD3sXltF2isrs%3D 12853193 (Pubitemid 36835815)
23. BF Uretsky K Thygesen PW Armstrong JG Cleland JD Horowitz BM Massie M Packer PA Poole-Wilson L Ryden 2000 Acute coronary findings at autopsy in heart failure patients with sudden death: results from the assessment of treatment with lisinopril and survival (ATLAS) trial Circulation 102 611 616 1:STN:280:DC%2BD3cvhtV2gsA%3D%3D 10931799
24. R Narang JG Cleland L Erhardt SG Ball AJ Coats AJ Cowley HJ Dargie AS Hall JR Hampton PA Poole-Wilson 1996 Mode of death in chronic heart failure. A request and proposition for more accurate classification Eur Heart J 17 1390 1403 1:STN:280:DyaK2s%2FjsVeluw%3D%3D 8880025
25. RH Sohn CB Deming DC Johns HC Champion C Bian K Gardner JJ Rade 2005 Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B Blood 105 3910 3917 10.1182/blood-2004-03-0928 10.1182/blood-2004-03-0928 1:CAS:528: DC%2BD2MXktlSrsLc%3D 15677570 (Pubitemid 40656136)
26. JJ Chiu BS Wung HJ Hsieh LW Lo DL Wang 1999 Nitric oxide regulates shear stress-induced early growth response-1. Expression via the extracellular signal-regulated kinase pathway in endothelial cells Circ Res 85 238 246 1:CAS:528:DyaK1MXltFGgsL4%3D 10436166
27. HJ Hsieh CC Cheng ST Wu JJ Chiu BS Wung DL Wang 1998 Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression J Cell Physiol 175 156 162 10.1002/(SICI)1097-4652(199805)175:2<156::AID-JCP5>3.0.CO;2-N 10.1002/(SICI)1097-4652(199805)175:2<156::AID-JCP5>3.0.CO;2-N 1:CAS:528:DyaK1cXit1Wls7w%3D 9525474 (Pubitemid 28140672)
28. M Sundaresan ZX Yu VJ Ferrans K Irani T Finkel 1995 Requirement for generation of H2O2 for platelet-derived growth factor signal transduction Science 270 296 299 10.1126/science.270.5234.296 10.1126/science.270.5234.296 1:CAS:528:DyaK2MXoslehs7c%3D 7569979
29. JW Chen FY Lin YH Chen TC Wu YL Chen SJ Lin 2004 Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells Arterioscler Thromb Vasc Biol 24 2075 2081 10.1161/01.ATV.0000145016.69181.fa 10.1161/01.ATV.0000145016.69181.fa 1:CAS:528:DC%2BD2cXptV2is7w%3D 15374848 (Pubitemid 39482433)
30. Y Mizuochi K Okajima N Harada P Molor-Erdene M Uchiba H Komura T Tsuda H Katsuya 2007 Carvedilol, a nonselective beta-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro Transl Res 149 223 230 10.1016/j.trsl.2006.11.008 10.1016/j.trsl.2006.11.008 1:CAS:528: DC%2BD2sXjsVCjtb4%3D 17383596 (Pubitemid 46442011)
31. AB Bridges NA Scott JJ Belch 1991 Probucol, a superoxide free radical scavenger in vitro Atherosclerosis 89 263 265 10.1016/0021-9150(91)90068-E 10.1016/0021-9150(91)90068-E 1:CAS:528:DyaK3MXmsVOrt7c%3D 1793454
32. D Zapolska-Downar A Zapolski-Downar M Markiewski A Ciechanowicz M Kaczmarczyk M Naruszewicz 2001 Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells Atherosclerosis 155 123 130 10.1016/S0021-9150(00)00553-0 10.1016/S0021-9150(00) 00553-0 1:CAS:528:DC%2BD3MXht1Oqsro%3D 11223433 (Pubitemid 32167131)
33. MK Offermann RM Medford 1994 Antioxidants and atherosclerosis: a molecular perspective Heart Dis Stroke 3 52 57 1:STN:280:DyaK2c7osVOguw%3D%3D 7511030
34. C Weber W Erl A Pietsch M Strobel HW Ziegler-Heitbrock PC Weber 1994 Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals Arterioscler Thromb 14 1665 1673 1:CAS:528:DyaK2cXmvFagt7g%3D 7522548
35. J Fruebis V Gonzalez M Silvestre W Palinski 1997 Effect of probucol treatment on gene expression of VCAM-1, MCP-1, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis Arterioscler Thromb Vasc Biol 17 1289 1302 1:CAS:528:DyaK2sXls1Wit7g%3D 9261259
36. TL Yue PJ McKenna JL Gu HY Cheng RR Ruffolo Jr GZ Feuerstein 1993 Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells Hypertension 22 922 928 1:CAS:528:DyaK2cXmvFWnuw%3D%3D 7902335
37. PJ Oliveira T Esteves AP Rolo CM Palmeira AJ Moreno 2004 Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism Cardiovasc Toxicol 4 11 20 10.1385/CT:4:1:11 10.1385/CT:4:1:11 1:CAS:528:DC%2BD2cXktlKgsL4%3D 15034201 (Pubitemid 38506960)
38. EH Ohlstein AJ Arleth B Storer AM Romanic 1998 Carvedilol inhibits endothelin-1 biosynthesis in cultured human coronary artery endothelial cells J Mol Cell Cardiol 30 167 173 10.1006/jmcc.1997.0582 10.1006/jmcc.1997.0582 1:CAS:528:DyaK1cXhtlGhsr4%3D 9500873 (Pubitemid 28069754)
39. L Kalinowski LW Dobrucki M Szczepanska-Konkel M Jankowski L Martyniec S Angielski T Malinski 2003 Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action Circulation 107 2747 2752 10.1161/01.CIR.0000066912. 58385.DE 10.1161/01.CIR.0000066912.58385.DE 1:CAS:528:DC%2BD3sXjvFKjtbs%3D 12742996
40. F Romeo D Li M Shi JL Mehta 2000 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway Cardiovasc Res 45 788 794 10.1016/S0008-6363(99) 00369-7 10.1016/S0008-6363(99)00369-7 1:CAS:528:DC%2BD3cXltVGrug%3D%3D 10728402 (Pubitemid 30047147)
41. L Rossig J Haendeler Z Mallat B Hugel JM Freyssinet A Tedgui S Dimmeler AM Zeiher 2000 Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol J Am Coll Cardiol 36 2081 2089 10.1016/S0735-1097(00)01002-0 10.1016/S0735-1097(00)01002-0 1:CAS:528: DC%2BD3cXptFSqtLo%3D 11127444
42. TL Yue HY Cheng PG Lysko PJ McKenna R Feuerstein JL Gu KA Lysko LL Davis G Feuerstein 1992 Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger J Pharmacol Exp Ther 263 92 98 1:CAS:528:DyaK3sXhtl2hsLw%3D 1357162