Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: Modulation of Fas/Fas ligand and caspase-3 pathway

Cardiovascular Research

Volumn 45, Issue 3, 2000, Pages 788-794

  Romeo, Frencesco ^a   Li, Dayuan ^b   Shi, Min ^b   Mehta, Jawahar L ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenergic (ant)agonists; Apoptosis; Endothelial function; Free radicals

Indexed keywords

ADRENALIN; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CASPASE 3; FAS ANTIGEN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTERY ENDOTHELIUM; ARTICLE; CELL CULTURE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; ENDOTHELIUM CELL; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; CARBAZOLES; CASPASE 3; CASPASES; CELLS, CULTURED; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; EPINEPHRINE; FAS LIGAND PROTEIN; FEMALE; HUMANS; IN SITU NICK-END LABELING; LIPID PEROXIDATION; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROPANOLAMINES; SIGNAL TRANSDUCTION;

EID: 0033979444     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00369-7     Document Type: Article

References (46)

1. Shimokawa H. Primary endothelial dysfunction: atherosclerosis. J Mol Cell Cardiol. 31:1999;23-37.
2. Boulanger C.M. Secondary endothelial dysfunction: hypertension and heart failure. J Mol Cell Cardiol. 31:1999;39-49.
3. Gross G.J., O'Rourke S.T., Pele L.R., Wartier D.C. Myocardial and endothelial dysfunction after multiple, brief coronary occlusion: role of oxygen radicals. Am J Physiol. 263:1992;H1703-H1709.
4. Harrison D.G. Endothelial dysfunction in the coronary microcirculation: a new clinical entity or an experimental finding? J Clin Invest. 91:1993;1-2.
5. Li D.Y., Yang B.C., Mehta J.L. Synergistic effect of tumor necrosis factor-α on anoxia-reoxygenation-mediated apoptosis in cultured human coronary endothelial cells. Cardiovasc Res. 42:1999;805-813.
6. Li D.Y., Yang B.C., Mehta J.L. Oxidized LDL enhances anoxia-reoxygenation-mediated apoptosis in human coronary endothelial cells: role of PKC, PTK, Bcl-2 and Fas. Am J Physiol. 275:1998;H568-H576.
7. Li D.Y., Yang B.C., Phillips M.I., Mehta J.L. Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT1 receptor and PKC activation. Am J Physiol. 276:1999;H786-H792.
8. Yoshikawa T., Baba A., Akaishi M., et al. Neurohumoral activations in congestive heart failure: correlations with cardiac function, heart rate variability, and baroreceptor sensitivity. Am Heart J. 137:(4 Pt 1):1999;666-671.
9. Noronha-Dutra A.A., Steen-Dutra E.M., Woolf N. Epinephrine-induced cytotoxicity of rat plasma. Its effects on isolated cardiac myocytes. Lab Invest. 59:1988;817-823.
10. Feuerstein G.Z., Smith E.F. III, Yue T.L., Cheng H.Y., Ruffolo R.R. Jr. Myocardial protection by the novel vasodilating β-blocker,carvedilol: potential relevance of antioxidant activity. J Hypertens. 214:1992;277-280.
11. Yue T.L., Ma X.L., Wang X., et al. Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol. Circ Res. 82:1998;166-174.
12. Basu S., Senior R., Raval U., et al. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial. Circulation. 96:1997;183-191.
13. Nagata S., Goldstein P. The Fas death factor. Science. 267:1995;1449-1456.
14. Hahne M., Rimoldi D., Schröter M., et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science. 274:1996;1363-1366.
15. Sata M., Walsh K. TNF-alpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation. Nat Med. 4:1998;415-420.
16. Hueber A.Q., Zornig M., Lyyon D., et al. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science. 278:1997;1305-1309.
17. Salvesen G.S., Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell. 91:1997;443-446.
18. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
19. Medema J.P., Scaffidi C., Kischkel F.C., et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16:1997;2794-2804.
20. Yang X., Chang H.Y., Baltimore D. Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell. 1:1998;319-325.
21. Communal C., Singh K., Primentel D.R., Colucci W.S. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation. 98:1998;1329-1334.
22. Zilkha-Falb R., Ziv I., Nardi N., et al. Monoamine-induced apoptotic neuronal cell death. Cell Mol Neurobiol. 17:1997;101-118.
23. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:1994;346-347.
24. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 119:1992;493-501.
25. Herrmann M., Lorenz H.M., Voll R., et al. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22:1994;5506-5507.
26. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:1979;351-358.
27. Miyamoto A., Ito K., Nishio A. Characterization of beta-adrenoceptors in pig basilar artery from functional and radioligand binding studies. Jpn J Pharmacol. 61:1993;93-99.
28. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol. 17:1985;291-306.
29. Polunovsky V.A., Wendt C.H., Ingbar D.H., Peterson M.S., Bitterman P.B. Induction of endothelial cell apoptosis by TNFa: modulation by inhibitors of protein synthesis. Exp Cell Res. 214:1994;584-594.
30. Opie L.H., Walpoth B., Barsacchi R. Calcium and catecholamines: relevance to cardiomyopathies and significance in therapeutic strategies. J Mol Cell Cardiol. 17:(suppl 2):1985;21-34.
31. Reed J.C., Miyashita T., Takayama S., et al. Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem. 60:1996;23-32.
32. Polunovsky V.A., Wendt C.H., Ingbar D.H., Peterson M.S., Bitterman P.B. Induction of endothelial cell apoptosis by TNFa: modulation by inhibitors of protein synthesis. Exp Cell Res. 214:1994;584-594.
33. Richardson B.C., Lalwani N.D., Johnson K.J., Marks R.M. Fas ligation triggers apoptosis in macrophages but not endothelial cells. Eur J Immunol. 24:1994;2640-2645.
34. Sata M., Walsh K. Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest. 102:1998;1682-1689.
35. Fraser A., Evan G. A license to kill. Cell. 85:1996;781-784.
36. Li D., Saldeen T., Mehta J.L. Gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in human coronary artery endothelial cells. Biochem Biophys Res Commun. 259:1999;157-161.
37. Yue T.L., Mckenna P.J., Gu J.L., et al. Carvedilol, a new antihypertensive agent prevent lipid peroxidation and oxidative injury to endothelial cells. Hypertension. 22:1993;922-928.
38. Yue T.L., Mckenna P.J., Gu J.L., et al. Carvedilol, a new vasodilating β-adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils. Cardiovasc Res. 28:1994;400-406.
39. Yue T.L., Wang X., Gu J.L., Ruffolo R.R. Jr, Freuerstein G.Z. Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation. Eur J Pharmacol. 294:1995;585-591.
40. Dimmeler S., Hermann C., Galle J., Zeiher A.M. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cells. Arterioscler Thromb Vasc Biol. 19:1999;656-664.
41. Foresti R., Sarathchandra P., Clark J.E., Green C.J., Motterlini R. Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis. Biochem J. 339:1999;729-736.
42. Gilbert E.M., Abraham W.T., Olsen S., et al. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation. 94:1996;2817-2825.
43. Packer M., Bristow M.R., Cohn J.N., et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. New Engl J Med. 334:1996;1349-1355.
44. Feuerstein G.Z., Yue T.L., Cheng H.Y., Ruffolo R.R. Jr. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 11:1993;S41-48.
45. Nagano T., O'Harrow S., Sponer G., Zimmer H.G. Norepinephrine-induced changes in rat heart function, metabolism, and weight are antagonized by carvedilol. J Cardiovasc Pharmacol. 21:1993;530-536.
46. Macdonald P.S., Keogh A.M., Aboyoun C.L., et al. Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure. J Am Coll Cardiol. 33:1999;924-931.