Scavenging of hypochlorous acid by carvedilol and ebselen in vitro

General Pharmacology

Volumn 28, Issue 2, 1997, Pages 269-272

  Aruoma, Okezie I ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

antihype rtensive drug; antioxidants; carvedilol; ebselen; glutathione; hypochlorous acid; inflammation; peroxidase

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; CARVEDILOL; CATALASE; EBSELEN; GLUTATHIONE PEROXIDASE; HYPOCHLOROUS ACID; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MODEL; PRIORITY JOURNAL; REACTION ANALYSIS;

AZOLES; CARBAZOLES; CATALASE; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HYPOCHLOROUS ACID; ORGANOSELENIUM COMPOUNDS; PROPANOLAMINES;

EID: 0031022445     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00232-7     Document Type: Article

References (52)

1. Ames B. N., Shigenaga M. K. and Hagen T. M. (1993) Oxidants, antioxidants and the degenerative disease of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
2. Andrews F. J., Morris C. J., Kondratowicz G. and Blake D. R. (1987) Effect of iron chelation on inflammatory joint disease. Ann. Rheum. Dis. 46, 327-333.
3. Aruoma O. I. (1993) Free Radicals in Tropical Diseases. Harwood Academic Publishers, London.
4. Aruoma O. I. (1994) Nutrition and health aspects of free radicals and antioxidants. Food Chem. Toxicol. 32, 671-683.
5. Aruoma O. I. (1996) Characterization of drugs as antioxidant prophylactics. Free Rad. Biol. Med. 20, 675-705.
6. Aruoma O. I. and Halliwell B. (1987) Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase. Biochem. J. 248, 973-976.
7. Aruoma O. I., Smith C., Cecchini R., Evans P. J. and Halliwell B. (1991) Free radical scavenging and inhibition of lipid peroxidation by β-blockers and by agents that interfere with calcium metabolism - a physiologically relevant process? Biochem. Pharmacol. 42, 735-743.
8. Babbs C. F. (1985) Role of iron ions in the genesis of reperfusion injury following successful cardiopulmonary resuscitation: preliminary data and a biochemical hypothesis. Ann. Emerg. Med. 14, 777-783.
9. Babior M. (1984) Oxidants from phagocytes: agents of defense and destruction. Blood 64, 959-966.
10. Biemond P., Swaak A. J. G., Van Eijk H. G. and Koster J. F. (1986) Intraarticular ferritin-bound iron in rheumatoid arthritis. A factor that increases oxygen free radical-induced tissue destruction. Arthritis Rheum. 29, 1187-1193.
11. Biemond P., Swaak A. J. G., Van Eijk H. G. and Koster J. F. (1988) Superoxide dependent iron release from ferritin in inflammatory diseases. Free Rad. Biol. Med. 4, 185-188.
12. Blake D. and Winyard P. G. (1995) Immunopharmacology of Free Radical Species. Academic, London.
13. Carp H. and Janoff A. (1980) Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha-1-proteinase inhibitor in vitro. J. Clin. Invest. 66, 987-995.
14. Christison J., Sies H. and Stocker R. (1994) Human blood cells support the reduction of low density lipoprotein associated cholesteryl ester hydroperoxide by albumin-bound ebselen. Biochem. J. 304, 341-345.
15. 1 protease inhibitor by human neutrophils. J. Biol. Chem. 256, 3348-3353.
16. Cotgreave I. A., Duddy S. K., Kass G. E. N., Thompson D. and Moldéus P. (1989) Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C? Biochem. Pharmacol. 38, 649-656.
17. Croft K. A., Dimmitt S. B., Moulton C. and Beilin L. J. (1992) Low density lipoprotein composition and oxidizability in coronary disease: apparent favorable effect of beta blockers. Atherosclerosis 97, 123-130.
18. Diamond R. D., Clark R. A. and Haudenschild C. C. (1980) Damage to Candida albicans hyphae and pseudohyphae by the myeloperoxidase system and oxidative products of neutrophil metabolism in vitro. J. Clin. Invest. 66, 908-917.
19. Feuerstein G. Z., Yue T.-L., Cheng, H.-Y. and Ruffolo R. R., Jr. (1993) Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of antioxidant activity. J. Hypertens. 11 (suppl. 4), S41-S48.
20. Goncalves T., Carvalho A. P. and Oliveira C. R. (1991) Antioxidant effect of calcium antagonists on microsomal membranes isolated from different brain areas. Eur. J. Pharmocol. 204, 315-322.
21. Green T. R., Fellman J. H. and Eicher A. L. (1985) Myeloperoxidase oxidation of sulfur-centred and benzoic acid hydroxyl radical scavengers. FEBS Lett. 192, 33-36.
22. Haenen G. R. M. M., de Rooij B. M., Vermeulen N. P. E. and Bast A. A. (1990) Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen. Mol. Pharmacol. 37, 412-422.
23. Halliwell B. (1994) Free radicals, antioxidants and human disease: curiosity, cause or consequence. Lancet 344, 721-724.
24. Halliwell B. and Gutteridge J. M. C. (1989) Free Radicals in Biology and Medicine. Clarendon, Oxford.
25. Halliwell B., Hoult J. R. S. and Blake D. R. (1988) Oxidants, inflammation and anti-inflammatory drugs. FASEB J. 2, 2867-2873.
26. Halliwell B., Aeschbach R., Löliger J. and Aruoma O. I. (1995) The characterization of antioxidants. Food Chem. Toxicol. 33, 601-617.
27. Henderson B., Edwards J. C. W. and Pettipher E. R. (1995) Mechanisms and Models in Rheumatoid Arthritis. Academic, London.
28. Janero D. R., and Burghard B. (1989) Antiperoxidant effect of dihydropyridine calcium antagonists. Biochem. Pharmacol. 38, 4344-4348.
29. Kalyanaraman B. and Sohnle P. G. (1985) Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants. J. Clin. Invest. 75, 1618-1622.
30. Little C. and O'Brien P. J. (1968) An intracellular GSH-peroxidase with a lipid peroxide substrate. Biochem. Biophys. Res. Commun. 31, 145-150.
31. Lysko P.G., Feuerstein G. Z. and Ruffolo R. R., Jr. (1995) Carvedilol: a novel multiple action antihypertensive drug. Pharmaceut. News, 12-16.
32. 1 proteinase inhibitor and human neutrophil myeloperoxidase. Biochemistry 24, 1941-1945.
33. Mctarish D., Campoli-Richards D. and Sorkin E. M. (1993) Carvedilol, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 45, 232-258.
34. Müller A., Cadenas E., Graf P. and Sies H. (1984) A novel biologically active seleno-organic compound. I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ51 (ebselen). Biochem. Pharmacol. 33, 3235-3239.
35. Müller A., Gabriel H. and Sies H. (1985) A novel biologically active selenoorganic compound. IV. Protective glutathione-dependent effect of PZ51 (ebselen) against ADP-Fe induced lipid peroxidation in isolated hepatocytes. Biochem. Pharmacol. 34, 1185-1189.
36. Noguchi N., Gotoh N. and Niki E. (1994) Effects of ebselen and probucol on oxidative modification of lipid and protein of low density lipoprotein induced by free radicals. Biochim. Biophys. Acta 1213, 176-182.
37. Pamham M. J., Leyck S., Graf E., Dowling E. J. and Blake D. R. (1991) The pharmacology of ebselen. Agent Action 32, 4-9.
38. Ramos C. L., Pou S., Britigan B. E., Cohen M. S. and Rosen G. M. (1992) Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes. J. Biol. Chem. 267, 8307-8312.
39. Rowley D. A. and Halliwell B. (1983) Formation of hydroxyl radicals from hydrogen peroxide and iron salts by superoxide- and ascorbate-dependent mechanisms: relevance to the pathology of rheumatoid disease. Clin. Sci. 64, 649-653.
40. Schewe T. (1995) Molecular actions of ebselen, an antiinflammatory antioxidant. Gen. Pharmacol. 26, 1153-1169.
41. Schewe C., Schewe T. and Wendel A. (1994) Strong inhibition of mammalian lipoxygenases by the anti-inflammatory selenoorganic compound ebselen in the absence of glutathione. Biochem. Pharmacol. 48, 65-74.
42. Sewell K. L. and Trentham D. E. (1993) Pathogenesis of rheumatoid arthritis. Lancet 341, 283-290.
43. Sies H. (1985) Oxidative Stress. Academic, London.
44. Sies H. (1993) Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Rad. Biol. Med. 14, 313-323.
45. Travis J. and Salvesen G. S. (1983) Human plasma proteinase inhibitor. Ann. Rev. Biochem. 52, 655-709.
46. van Dyke T. E., Braswell L. and Offenbacher S. (1986) Inhibition of gingervitis by topical application of ebselen and rosmarinic acid. Agent Action 19, 376-377.
47. Vissers McM. and Winterbourn C. C. (1986) The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen. Biochim. Biophys. Acta 889, 277-286.
48. 1-antiproteinase by hypochlorous acid and by hydrogen peroxide. Biochem. J. 243, 219-223.
49. Weiss S. J. (1989) Tissue destruction by neutrophils. N. Engl. J. Med. 320, 365-376.
50. Weiss S. J., Klein R., Slivka A. and Wei M. (1982) Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J. Clin. Invest. 70, 598-607.
51. Yoshikawa T. (1993) Free radicals and their scavengers in Parkinson's disease. Eur. Neurol. 33, 60-68.
52. Yue T. L., Cheng. H.-Y., Lysko P. G. et al. (1992) Carvedilol, a new vasodilator and β-adrenoceptor antagonist, is an antioxidant and free radical scavenger. J. Pharmacol. Exp. Ther. 263, 92-98.