Polysialylation of NCAM

Advances in Experimental Medicine and Biology

Volumn 663, Issue , 2010, Pages 95-109

  Hildebrandt, Herbert ^b   Mühlenhoff, Martina ^b   Gerardy Schahn, Rita ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN; ISOPROTEIN; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 120; NERVE CELL ADHESION MOLECULE 140; NERVE CELL ADHESION MOLECULE 180; SIALIC ACID; SIALYLTRANSFERASE; UNCLASSIFIED DRUG; POLYSACCHARIDE; POLYSIALIC ACID; SIALIC ACID DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CANCER GROWTH; CELL COMPARTMENTALIZATION; CENTRAL NERVOUS SYSTEM; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE TARGETING; GLYCOSYLATION; HUMAN; LUNG SMALL CELL CANCER; NEUROBLASTOMA; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN POLYSIALYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RHABDOMYOSARCOMA; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; NEOPLASM; REVIEW;

ANIMALS; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASMS; NEURAL CELL ADHESION MOLECULES; POLYSACCHARIDES; SIALIC ACIDS; SIALYLTRANSFERASES;

EID: 77949903021     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1170-4_6     Document Type: Article

References (120)

1. Fujimoto I, Bruses JL, Rutishauser U (2001) Regulation of cell adhesion by polysialic acid: effects on cadherin, IgCAM and integrin function and independence from NCAM binding or signaling activity. J Biol Chem 276:31745-31751
2. Johnson CP, Fragneto G, Konovalov O et al (2005) Structural studies of the neural-celladhesion molecule by X-ray and neutron reflectivity. Biochemistry 44:546-554 (Pubitemid 40105485)
3. Johnson CP, Fujimoto I, Rutishauser U et al (2005) Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion. J Biol Chem 280:137-145 (Pubitemid 40164974)
4. Kleene R, Schachner M (2004) Glycans and neural cell interactions. Nat Rev Neurosci 5:195-208 (Pubitemid 38252476)
5. Bonfanti L (2006) PSA-NCAM in mammalian structural plasticity and neurogenesis. Prog Neurobiol 80:129-164 (Pubitemid 44739166)
6. Gascon E, Vutskits L, Kiss JZ (2007) Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons. Brain Res Rev 56:101-118 (Pubitemid 350100865)
7. Hildebrandt H, Mühlenhoff M, Weinhold B et al (2007) Dissecting polysialic acid and NCAM functions in brain development. J Neurochem 103(Suppl 1):56-64
8. Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26-35 (Pubitemid 350295686)
9. Edelman GM, Chuong CM (1982) Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci USA 79:7036-7040 (Pubitemid 13170926)
10. Rothbard JB, Brackenbury R, Cunningham BA et al (1982) Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains. J Biol Chem 257:11064-11069 (Pubitemid 13208914)
11. Lackie PM, Zuber C, Roth J (1991) Expression of polysialylated N-CAM during rat heart development. Differentiation 47:85-98
12. Lackie PM, Zuber C, Roth J (1994) Polysialic acid of the neural cell adhesion molecule (N-CAM) is widely expressed during organogenesis in mesodermal and endodermal derivatives. Differentiation 57:119-131 (Pubitemid 24211107)
13. Probstmeier R, Bilz A, Schneider-Schaulies J (1994) Expression of the neural cell adhesion molecule and polysialic acid during early mouse embryogenesis. J Neurosci Res 37:324-335 (Pubitemid 24072919)
14. Kurosawa N, Yoshida Y, Kojima N et al (1997) Polysialic acid synthase (ST8Sia II STX) mRNA expression in the developing mouse central nervous system. J Neurochem 69:494-503 (Pubitemid 27327950)
15. Galuska SP, Oltmann-Norden I, Geyer H et al (2006) Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J Biol Chem 281:31605-31615 (Pubitemid 46041426)
16. Oltmann-Norden I, Galuska SP, Hildebrandt H et al (2008) Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J Biol Chem 283:1463-1471
17. Seki T, Arai Y (1993) Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neurosci Res 17:265-290 (Pubitemid 23298835)
18. Angata K, Fukuda M (2003) Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule. Biochimie 85:195-206 (Pubitemid 36625994)
19. Bruses JL, Rutishauser U (1998) Regulation of neural cell adhesion molecule polysialylation: evidence for nontranscriptional control and sensitivity to an intracellular pool of calcium. J Cell Biol 140:1177-1186 (Pubitemid 28128877)
20. Gallagher HC, Odumeru OA, Regan CM (2000) Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. J Neurosci Res 61:636-645
21. Gallagher HC, Murphy KJ, Foley AG et al (2001) Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain. J Neurochem 77:425-434 (Pubitemid 32298737)
22. Kiss JZ, Wang C, Olive S et al (1994) Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells. EMBO J 13:5284-5292 (Pubitemid 24351806)
23. Muller D, Wang C, Skibo G et al (1996) PSA-NCAM is required for activity-induced synaptic plasticity. Neuron 17:413-422 (Pubitemid 26322213)
24. Roth J, Zuber C, Komminoth P, Scheidegger EP, Warhol MJ, Bitter-Suermann D, Heitz PU (1993) Expression of polysialic acid in human tumors and its significance for tumor growth. In: Roth J, Rutishauser U, Troy FA (eds) Polysialic acid. Birkhäuser Verlag, Basel, pp 335-348
25. Fukuda M (1996) Possible roles of tumor-associated carbohydrate antigens. Cancer Res 56:2237-2244 (Pubitemid 26154066)
26. Fuster MM, Esko JD (2005) The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer 5:526-542 (Pubitemid 40942829)
27. Roth J, Zuber C, Wagner P et al (1988) Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms tumor. Proc Natl Acad Sci USA 85:2999-3003
28. Figarella-Branger D, Durbec PL, Rougon GN (1990) Differential spectrum of expression of neural cell adhesion molecule isoforms and L1 adhesion molecules on human neuroectodermal tumors. Cancer Res 50:6364-6370 (Pubitemid 20323701)
29. Komminoth P, Roth J, Lackie PM et al (1991) Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids. Am J Pathol 139:297-304
30. Kaiser U, Auerbach B, Oldenburg M (1996) The neural cell adhesion molecule NCAM in multiple myeloma. Leuk Lymphoma 20:389-395 (Pubitemid 26096044)
31. Glüer S, Schelp C, Madry N et al (1998) Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma. Br J Cancer 78:106-110 (Pubitemid 28276778)
32. Glüer S, Schelp C, Von Schweinitz D et al (1998) Polysialylated neural cell adhesion molecule in childhood rhabdomyosarcoma. Pediatr Res 43:145-147 (Pubitemid 28069181)
33. Hildebrandt H, Becker C, Glüer S et al (1998) Polysialic acid on the neural cell adhesion molecule correlates with expression of polysialyltransferases and promotes neuroblastoma cell growth. Cancer Res 58:779-784 (Pubitemid 28099491)
34. Seidenfaden R, Gerardy-Schahn R, Hildebrandt H (2000) Control of NCAM polysialylation by the differential expression of polysialytransferases ST8SiaII and ST8SiaIV. Eur J Cell Biol 79:680-688
35. Tanaka F, Otake Y, Nakagawa T et al (2000) Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer. Cancer Res 60:3072-3080 (Pubitemid 30395837)
36. Trouillas J, Daniel L, Guigard MP et al (2003) Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion. J Neurosurg 98:1084-1093 (Pubitemid 36460901)
37. Scheidegger EP, Lackie PM, Papay J et al (1994) In vitro and in vivo growth of clonal sublines of human small cell lung carcinoma is modulated by polysialic acid of the neural cell adhesion molecule. Lab Invest 70:95-106 (Pubitemid 24080109)
38. Daniel L, Trouillas J, Renaud W et al (2000) Polysialylated-neural cell adhesion molecule expression in rat pituitary transplantable tumors (spontaneous mammotropic transplantable tumor in Wistar-Furth rats) is related to growth rate and malignancy. Cancer Res 60:80-85 (Pubitemid 30058735)
39. Daniel L, Durbec P, Gautherot E et al (2001) A nude mice model of human rhabdomyosarcoma lung metastases for evaluating the role of polysialic acids in the metastatic process. Oncogene 20:997-1004 (Pubitemid 32207117)
40. Suzuki M, Suzuki M, Nakayama J et al (2005) Polysialic acid facilitates tumor invasion by glioma cells. Glycobiology 15:887-894 (Pubitemid 41226404)
41. Seidenfaden R, Krauter A, Schertzinger F et al (2003) Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions. Mol Cell Biol 23:5908-5918 (Pubitemid 36951351)
42. Seidenfaden R, Krauter A, Hildebrandt H (2006) The neural cell adhesion molecule NCAM regulates neuritogenesis by multiple mechanisms of interaction. Neurochem Int 49:1-11 (Pubitemid 43669147)
43. Glüer S, Zense M, Radtke E et al (1998) Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage. Langenbecks Arch Surg 383:340-344 (Pubitemid 28527031)
44. Cheung IY, Vickers A, Cheung NK (2006) Sialyltransferase STX (ST8SiaII): a novel molecular marker of metastatic neuroblastoma. Int J Cancer 119:152-156
45. Edvardsen K, Pedersen PH, Bjerkvig R et al (1994) Transfection of glioma cells with the neural-cell adhesion molecule NCAM: effect on glioma-cell invasion and growth in vivo. Int J Cancer 58:116-122 (Pubitemid 24213978)
46. Sasaki H, Yoshida K, Ikeda E et al (1998) Expression of the neural cell adhesion molecule in astrocytic tumors: an inverse correlation with malignancy. Cancer 82:1921-1931 (Pubitemid 28208649)
47. Perl AK, Dahl U, Wilgenbus P et al (1999) Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nat Med 5:286-291 (Pubitemid 29124363)
48. Eckhardt M, Mühlenhoff M, Bethe A et al (1995) Molecular characterization of eukaryotic polysialyltransferase-1. Nature 373:715-718
49. Nakayama J, Fukuda MN, Fredette B et al (1995) Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. Proc Natl Acad Sci USA 92:7031-7035
50. Scheidegger EP, Sternberg LR, Roth J et al (1995) A human STX cDNA confers polysialic acid expression in mammalian cells. J Biol Chem 270:22685-22688
51. Kojima N, Yoshida Y, Tsuji S (1995) A developmentally regulated member of the sialyltransferase family (ST8Sia II, STX) is a polysialic acid synthase. FEBS Lett 373:119-122
52. Datta AK, Paulson JC (1995) The sialyltransferase "sialylmotif" participates in binding the donor substrate CMP-NeuAc. J Biol Chem 270:1497-1500
53. Datta AK, Sinha A, Paulson JC (1998) Mutation of the sialyltransferase S-sialylmotif alters the kinetics of the donor and acceptor substrates. J Biol Chem 273:9608-9614 (Pubitemid 28183048)
54. Inoue S, Lin SL, Inoue Y (2000) Chemical analysis of the developmental pattern of polysialylation in chicken brain expression of only an extended form of polysialyl chains during embryogenesis and the presence of disialyl residues in both embryonic and adult chicken brains. J Biol Chem 275:29968-29979
55. Nakata D, Troy FA (2005) Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion molecules (N-CAMS): development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS. J Biol Chem 280:38305-38316 (Pubitemid 43853728)
56. Galuska SP, Geyer R, Gerardy-Schahn R et al (2008) Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivo. J Biol Chem 283:17-28
57. Zuber C, Lackie PM, Catterall WA et al (1992) Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAM in adult rat brain. J Biol Chem 267:9965-9971
58. Yabe U, Sato C, Matsuda T et al (2003) Polysialic acid in human milk. CD36 is a new member of mammalian polysialic acid-containing glycoprotein. J Biol Chem 278:13875-13880 (Pubitemid 36799927)
59. Curreli S, Arany Z, Gerardy-Schahn R et al (2007) Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions. J Biol Chem 282:30346-30356 (Pubitemid 350035196)
60. Mühlenhoff M, Eckhardt M, Bethe A et al (1996) Autocatalytic polysialylation of polysialyltransferase-1. EMBO J 15:6943-6950 (Pubitemid 27023265)
61. Close BE, Colley KJ (1998) In vivo autopolysialylation and localization of the polysialyltransferases PST and STX. J Biol Chem 273:34586-34593 (Pubitemid 29008942)
62. Close BE, Tao K, Colley KJ (2000) Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule. J Biol Chem 275:4484-4491 (Pubitemid 30094693)
63. Weinhold B, Seidenfaden R, Röckle I et al (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem 280:42971-42977 (Pubitemid 43049260)
64. Mühlenhoff M, Eckhardt M, Bethe A et al (1996) Polysialylation of NCAM by a single enzyme. Curr Biol 6:1188-1191 (Pubitemid 26368754)
65. Angata K, Suzuki M, Fukuda M (1998) Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. J Biol Chem 273:28524-28532 (Pubitemid 28496160)
66. Nelson RW, Bates PA, Rutishauser U (1995) Protein determinants for specific polysialylation of the neural cell adhesion molecule. J Biol Chem 270:17171-17179
67. Liedtke S, Geyer H, Wuhrer M et al (2001) Characterization of N-glycans from mouse brain neural cell adhesion molecule. Glycobiology 11:373-384 (Pubitemid 32685212)
68. von der Ohe M, Wheeler SF, Wuhrer M et al (2002) Localization and characterization of polysialic acid-containing N-linked glycans from bovine NCAM. Glycobiology 12:47-63 (Pubitemid 34218318)
69. Kudo M, Kitajima K, Inoue S et al (1996) Characterization of the major core structures of the alpha2->8- linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains. J Biol Chem 271:32667-32677 (Pubitemid 27008689)
70. Geyer H, Bahr U, Liedtke S et al (2001) Core structures of polysialylated glycans present in neural cell adhesion molecule from newborn mouse brain. Eur J Biochem 268:6587-6599 (Pubitemid 34014766)
71. Wuhrer M, Geyer H, von der Ohe M et al (2003) Localization of defined carbohydrate epitopes in bovine polysialylated NCAM. Biochimie 85:207-218 (Pubitemid 36625995)
72. Mendiratta SS, Sekulic N, Hernandez-Guzman FG et al (2006) A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation. J Biol Chem 281:36052-36059 (Pubitemid 46041338)
73. Kojima N, Tachida Y, Yoshida Y et al (1996) Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase - requirement of core alpha-1, 6-linked fucose and a polypeptide chain for polysialylation. J Biol Chem 271:19457-19463 (Pubitemid 26271619)
74. Angata K, Suzuki M, McAuliffe J et al (2000) Differential Biosynthesis of Polysialic Acid on NCAM and Oligosaccharide Acceptors by Three Distinct a2, 8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. J Biol Chem 275:18594-18601 (Pubitemid 30414823)
75. Angata K, Suzuki M, Fukuda M (2002) ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. J Biol Chem 277:36808-36817
76. Kitazume-Kawaguchi S, Kabata S, Arita M (2001) Differential Biosynthesis of Polysialic or Disialic Acid Structure by ST8Sia II and ST8Sia IV. J Biol Chem 276:15696-15703
77. Eckhardt M, Bukalo O, Chazal G et al (2000) Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity. J Neurosci 20:5234-5244 (Pubitemid 30457720)
78. Angata K, Long JM, Bukalo O et al (2004) Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior. J Biol Chem 279:32603-32613 (Pubitemid 39014717)
79. Angata K, Nakayama J, Fredette B et al (1997) Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule - tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase PST. J Biol Chem 272:7182-7190 (Pubitemid 27166425)
80. Phillips GR, Krushel LA, Crossin KL (1997) Developmental expression of two rat sialyltransferases that modify the neural cell adhesion molecule N-CAM. Dev Brain Res 102:143-155 (Pubitemid 27435934)
81. Hildebrandt H, Becker C, Mürau M et al (1998) Heterogeneous expression of the polysialyltransferases ST8Sia II and ST8Sia IV during postnatal rat brain development. J Neurochem 71:2339-2348 (Pubitemid 28531244)
82. Ong E, Nakayama J, Angata K et al (1998) Developmental regulation of polysialic acid synthesis in mouse directed by two polysialyltransferases, PST and STX. Glycobiology 8:415-424 (Pubitemid 28186641)
83. Yoshida Y, Kurosawa N, Kanematsu T et al (1996) Genomic structure and promoter activity of the mouse polysialic acid synthase gene (mST8Sia II) - brain-specific expression from a tata-less gc-rich sequence. J Biol Chem 271:30167-30173 (Pubitemid 26389659)
84. Eckhardt M, Gerardy-Schahn R (1998) Genomic organization of the murine polysialyltransferase gene ST8SiaIV (PST-1). Glycobiology 8:1165-1172 (Pubitemid 29008357)
85. Takashima S, Yoshida Y, Kanematsu T et al (1998) Genomic structure and promoter activity of the mouse polysialic acid synthase (mST8Sia IV/PST) gene. J Biol Chem 273:7675-7683 (Pubitemid 28152796)
86. Seidenfaden R, Hildebrandt H (2001) Retinoic acid-induced changes in NCAM polysialylation and polysialyltransferase mRNA expression of human neuroblastoma cells. J Neurobiol 46:11-28 (Pubitemid 32011930)
87. Beecken WD, Engl T, Ogbomo H et al (2005) Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells. Int Immunopharmacol 5:757-769 (Pubitemid 40248330)
88. Mayanil CS, George D, Mania-Farnell B et al (2000) Overexpression of murine Pax3 increases NCAM polysialylation in a human medulloblastoma cell line. J Biol Chem 275(30):23259-23266 (Pubitemid 30646225)
89. Marx M, Rivera-Milla E, Stummeyer K et al (2007) Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison. Dev Biol 306:560-571 (Pubitemid 46873535)
90. Rieger S, Volkmann K, Koster RW (2008) Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish. Dev Dyn 237:276-285
91. Vaithianathan T, Matthias K, Bahr B et al (2004) Neural cell adhesion molecule-associated polysialic acid potentiates alpha-amino-3-hydroxy-5- methylisoxazole-4-propionic acid receptor currents. J Biol Chem 279:47975-47984 (Pubitemid 39540949)
92. Hammond MS, Sims C, Parameshwaran K et al (2006) NCAM associated polysialic acid inhibits NR2B-containing NMDA receptors and prevents glutamate-induced cell death. J Biol Chem 281:34859-34869 (Pubitemid 46036525)
93. Senkov O, Sun M, Weinhold B et al (2006) Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J Neurosci 26:10888-10898
94. Stoenica L, Senkov O, Gerardy-Schahn R et al (2006) In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Eur J NeuroSci 23:2255-2264 (Pubitemid 43742858)
95. Cremer H, Lange R, Christoph A et al (1994) Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367:455-459 (Pubitemid 24046046)
96. Tomasiewicz H, Ono K, Yee D et al (1993) Genetic deletion of a neural cell adhesion molecule variant (N- CAM-180) produces distinct defects in the central nervous system. Neuron 11:1163-1174 (Pubitemid 24015289)
97. Ono K, Tomasiewicz H, Magnuson T et al (1994) N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid. Neuron 13:595-609
98. Hu H, Tomasiewicz H, Magnuson T et al (1996) The role of polysialic acid in migration of olfactory bulb interneuron precursors in the subventricular zone. Neuron 16:735-743 (Pubitemid 26124051)
99. Chazal G, Durbec P, Jankovski A et al (2000) Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse. J Neurosci 20:1446-1457 (Pubitemid 30220424)
100. Cremer H, Chazal G, Goridis C et al (1997) NCAM is essential for axonal growth and fasciculation in the hippocampus. Mol Cell Neurosci 8:323-335 (Pubitemid 127796472)
101. Seki T, Rutishauser U (1998) Removal of polysialic acid-neural cell adhesion molecule induces aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus. J Neurosci 18:3757-3766 (Pubitemid 28225683)
102. Angata K, Huckaby V, Ranscht B et al (2007) Polysialic acid-directed migration and differentiation of neural precursors is essential for mouse brain development. Mol Cell Biol 27:6659-6668 (Pubitemid 47483620)
103. Gravvanis AI, Lavdas A, Papalois AE et al (2005) Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting. Microsurgery 25:423-432 (Pubitemid 41098673)
104. El Maarouf A, Petridis AK, Rutishauser U (2006) Use of polysialic acid in repair of the central nervous system. Proc Natl Acad Sci USA 103:16989-16994 (Pubitemid 44737365)
105. Lavdas AA, Franceschini I, Dubois-Dalcq M et al (2006) Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro. Glia 53:868-878
106. Papastefanaki F, Chen J, Lavdas AA et al (2007) Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. Brain 130:2159-2174 (Pubitemid 47236630)
107. Glaser T, Brose C, Franceschini I et al (2007) Neural cell adhesion molecule polysialylation enhances the sensitivity of embryonic stem cell-derived neural precursors to migration guidance cues. Stem Cells 25:3016-3025 (Pubitemid 350294426)
108. Zhang Y, Ghadiri-Sani M, Zhang X et al (2007) Induced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons. Mol Cell Neurosci 35:109-119 (Pubitemid 46636307)
109. Zhang Y, Zhang X, Wu D et al (2007) Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord. Mol Ther 15:1796-1804 (Pubitemid 47434186)
110. Zhang Y, Zhang X, Yeh J et al (2007) Engineered expression of polysialic acid enhances Purkinje cell axonal regeneration in L1/GAP-43 double transgenic mice. Eur J NeuroSci 25:351-361
111. Haile Y, Haastert K, Cesnulevicius K et al (2007) Culturing of glial and neuronal cells on polysialic acid. Biomaterials 28:1163-1173 (Pubitemid 44816379)
112. Bruns S, Stark Y, Roker S et al (2007) Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair. J Biotechnol 131:335-345 (Pubitemid 47371166)
113. Haile Y, Berski S, Dräger G et al (2008) The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells. Biomaterials 29:1880-1891
114. Stark Y, Bruns S, Stahl F et al (2008) A study on polysialic acid as a biomaterial for cell culture applications. J Biomed Mater Res A 85:1-13 (Pubitemid 351355350)
115. Stummeyer K, Dickmanns A, Mühlenhoff M et al (2005) Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nat Struct Mol Biol 12:90-96 (Pubitemid 40082922)
116. Jakobsson E, Jokilammi A, Aalto J et al (2007) Identification of amino acid residues at the active site of endosialidase that dissociate the polysialic acid binding and cleaving activities in Escherichia coli K1 bacteriophages. Biochem J 405:465-472 (Pubitemid 47172043)
117. Schwarzer D, Stummeyer K, Gerardy-Schahn R et al (2007) Characterization of a novel intramolecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins. J Biol Chem 282:2821-2831 (Pubitemid 47084314)
118. Berezin V, Bock E (2004) NCAM mimetic peptides: pharmacological and therapeutic potential. J Mol Neurosci 22:33-39 (Pubitemid 41359013)
119. Torregrossa P, Buhl L, Bancila M et al (2004) Selection of poly-alpha 2, 8-sialic acid mimotopes from a random phage peptide library and analysis of their bioactivity. J Biol Chem 279:30707-30714
120. Florian C, Foltz J, Norreel JC et al (2006) Post-training intrahippocampal injection of synthetic poly-alpha-2, 8-sialic acid-neural cell adhesion molecule mimetic peptide improves spatial long-term performance in mice. Learn Mem 13:335-341 (Pubitemid 43830680)