Identification of amino acid residues at the active site of endosialidase that dissociate the polysialic acid binding and cleaving activities in Escherichia coli K1 bacteriophages

Biochemical Journal

Volumn 405, Issue 3, 2007, Pages 465-472

  Jakobsson, Elina ^a   Jokilammi, Anne ^a   Aalto, Juha ^a   Ollikka, Pauli ^a   Lehtonen, Jukka V ^b   Hirvonen, Harri ^c   Finne, Jukka ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b FBD Ltd   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Bacteriophage; Catalytic activity; Endosialidase (endo N acetylneuraminidase); Host range mutant; Polysialic acid

Indexed keywords

ENDOSIALIDASE; HOST RANGE MUTANT; POLYSIALIC ACID;

BACTERIOPHAGES; CATALYST ACTIVITY; CHEMICAL BONDS; ENZYMES; ESCHERICHIA COLI; POLYSACCHARIDES;

AMINO ACIDS;

AMINO ACID; ENDOSIALIDASE; HYBRID PROTEIN; OLIGONUCLEOTIDE; POLYSIALIC ACID; SIALIDASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; BACTERIOPHAGE; ENZYME ACTIVITY; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; SEPSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BACTERIOPHAGES; BASE SEQUENCE; BINDING SITES; CELL LINE; COLIPHAGES; CRICETINAE; ESCHERICHIA COLI; HUMANS; MOLECULAR SEQUENCE DATA; NEURAMINIDASE; POINT MUTATION; SIALIC ACIDS;

ESCHERICHIA COLI;

EID: 34547452769     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070177     Document Type: Article

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