Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFα), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia

Clinical Rheumatology

Volumn 29, Issue 2, 2010, Pages 189-197

  Blanco, Ignacio ^a   Janciauskiene, Sabina ^b   Nita, Izabela ^b   Fernández Bustillo, Enrique ^c   Cárcaba, Victoriano ^a   Gallo, César ^a   Álvarez Rico, Marlene ^a   De Serres, Frederick ^d   Béridze, Nana ^e  

^a Valle del Nalon Hospital   (Spain)

^b Malmö University Hospital   (Sweden)

^c Biostatistics Unit   (Spain)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e Department of Pathology   (Spain)

Author keywords

Cytokines; Fibromyalgia; Genetics

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE; BRONCHODILATING AGENT; CALCIUM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRONE; DIURETIC AGENT; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; OPIATE; PARACETAMOL; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPSIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR I; TUMOR NECROSIS FACTOR ALPHA RECEPTOR II; UNCLASSIFIED DRUG; VASCULOTROPIN; VITAMIN; VASCULOTROPIN A;

ADULT; ALPHA ANTITRYPSIN DEFICIENCY; ARTICLE; CONTROLLED STUDY; DRUG USE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROMYALGIA; FIBROMYALGIA SYNDROME; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; ALPHA 1 ANTITRYPSIN DEFICIENCY; BLOOD; GENETICS; MIDDLE AGED; NONPARAMETRIC TEST; RECEIVER OPERATING CHARACTERISTIC; REGRESSION ANALYSIS;

ALPHA 1-ANTITRYPSIN DEFICIENCY; CHEMOKINE CCL2; FEMALE; FIBROMYALGIA; GENOTYPE; HUMANS; MIDDLE AGED; REGRESSION ANALYSIS; ROC CURVE; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77949887122     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-009-1318-5     Document Type: Article

References (57)

1. F Wolfe HA Smythe MB Yunus RM Bennett C Bombardier DL Goldenberg P Tugwell SM Campbell M Abeles P Clark AG Fam SJ Farber JJ Fiechtner CM Franklin RA Gatter D Hamaty J Lessard AS Lichtbroun AT Masi GA McCain WJ Reynolds TJ Romano IJ Russell RP Sheon The American College of Rheumatology 1990 Criteria for the classification of fibromyalgia Arthritis Rheum 33 160 172 10.1002/art.1780330203 1:STN:280:DyaK3c7ms1Sguw%3D%3D 2306288
2. DJ Wallace M Linker-Israeli D Hallegua S Silverman D Silver MH Weisman 2001 Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study Rheumathology (Oxford) 40 7 743 749 10.1093/rheumatology/40.7.743 1:CAS:528:DC%2BD3MXmsV2mtbk%3D
3. R Staud DD Pierce ME Robinson AP Mauderli CJ Vierck 2004 Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls Pain 110 3 689 696 10.1016/j.pain.2004.05. 009 15288410 (Pubitemid 39036801)
4. M Maes I Libbrecht F Van Hunsel AH Lin L De Clerck W Stevens G Kenis R de Jongh E Bosmans H Neels 1999 The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines Psychoneuroendocrinology 24 4 371 383 10.1016/S0306-4530(98)00087-0 1:CAS:528:DyaK1MXivFWjsb0%3D 10341365 (Pubitemid 29204800)
5. A Gur M Karakoc K Nas C Remzi A Denli J Sarac 2002 Cytokines and depression in cases with fibromyalgia J Rheumatol 29 2 358 361 11838856
6. G Hein S Franke 2002 Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia? Rheumatology (Oxford) 41 10 1163 1167 10.1093/rheumatology/41.10.1163 1:CAS:528:DC%2BD38XovFOqurs%3D
7. M Pache J Ochs E Genth R Mierau T Kube J Flammer 2003 Increased plasma endothelin-1 levels in fibromyalgia syndrome Rheumathology 42 493 494 10.1093/rheumatology/keg131 1:CAS:528:DC%2BD3sXit12ls7o%3D (Pubitemid 36367551)
8. S Bagis L Tamer G Sahin G Sahin R Bilgin H Guler B Ercan C Erdogan 2003 Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 28 188 190
9. S Ozgocmen H Ozyurt S Sogut O Akyol O Ardicoglu H Yildizhan 2006 Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns Rheumatol Int 26 7 598 603 10.1007/s00296-005-0079-y 1:CAS:528:DC%2BD28XjsVeksLs%3D 16283318
10. N Uceyler R Valenza M Stock R Schedel G Sprotte C Sommer 2006 Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain Arthritis Rheum 54 8 2656 2664 10.1002/art.22026 16871547 1:CAS:528: DC%2BD28XpsFGnsLs%3D (Pubitemid 44205028)
11. L Bazzichi A Rossi G Massimetti G Giannaccini T Giuliano F De Feo A Ciapparelli L Dell'Osso S Bombardieri 2007 Cytokine patterns in fibromyalgia and their correlation with clinical manifestations Clin Exp Rheumatol 25 2 225 230 1:STN:280:DC%2BD2szjtF2nsw%3D%3D 17543146
12. O Altindag A Gur N Calgan N Soran H Celik S Selek 2007 Paraoxonase and arylesterase activities in fibromyalgia Redox Rep 12 3 134 138 1:CAS:528:DC%2BD2sXptlKqtrs%3D 17623520
13. H Wang M Moser M Schiltenwolf M Buchner 2008 Circulating cytokine levels compared to pain in patients with fibromyalgia-a prospective longitudinal study over 6 months J Rheumatol 35 7 11
14. Z Zhang G Cherryholmes A Mao C Marek J Longmate M Kalos RP St Amand JE Shively 2008 High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia Exp Biol Med 233 9 1171 1180 10.3181/0712-RM-328 1:CAS:528:DC%2BD1cXhtVyrs77O
15. CP Chung D Titova A Oeser M Randels I Avalos GL Milne JD Morrow CM Stein 2008 Oxidative stress in fibromyalgia and its relationship to symptoms Clin Rheumatol 28 4 435 438 10.1007/s10067-008-1072-0 19089486
16. MD Cordero AM Moreno-Fernández M Demiguel P Bonal F Campa LM Jiménez-Jiménez A Ruiz-Losada B Sánchez-Domínguez JA Sánchez Alcázar L Salviati P Navas 2008 Coenzyme Q10 distribution in blood is altered in patients with Fibromyalgia Clin Biochem 42 7-8 732 735 19133251
17. J Ablin L Neumann D Buskila 2008 Pathogenesis of fibromyalgia-a review Joint Bone Spine 75 3 273 279 10.1016/j.jbspin.2007.09.010 1:CAS:528: DC%2BD1cXnsFWkt74%3D 18375167
18. I Blanco H Canto FJ de Serres EF Bustillo MC Rodríguez 2004 Alpha-1-antitrypsin replacement therapy efficiently controls fibromyalgia symptoms in two PI ZZ alpha-1-antitrypsin deficiency patients J Rheumatol 31 10 2082 2085 15468381
19. I Blanco D Arbesú D Al Kassam F De Serres E Fernández- Bustillo C Rodríguez Menéndez 2006 Alpha1-antitrypsin polymorphism in fibromyalgia patients from the Asturias Province in Northern Spain: a significantly higher prevalence of the PIZ deficiency allele in patients than in the general population J Musculoske Pain 14 3 5 12 10.1300/J094v14n03-02 (Pubitemid 44352911)
20. I Blanco FJ de Serres S Janciauskiene D Arbesú EF Bustillo V Cárcaba I Nita A Astudillo 2007 Estimates of the prevalence and number of fibromyalgia syndrome patients and their alpha-1 antitrypsin phenotypic distribution in ten countries J Musculoske Pain 15 4 9 23 10.1300/J094v15n04-03 (Pubitemid 47414275)
21. Blanco I, Astudillo A, Domínguez F, Janciauskiene S, Cárcaba V, Gallo C, Canto H, de Serres F, Fernández-Bustillo E (2009) Intravenous Infusions of Purified Alpha 1-Antitrypsin Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ-Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient. J Musculoske Pain (in press)
22. IJ Russell 2006 Alpha1-antitrypsin deficiency in the fibromyalgia syndrome J Musculoske Pain 14 3 1 3 10.1300/J094v14n03-01 (Pubitemid 44352910)
23. IJ Russell 2007 Pathogenesis of the fibromyalgia syndrome J Musculoske Pain 15 4 5 8 10.1300/J094v15n04-02 (Pubitemid 47414274)
24. I Blanco FJ de Serres E Fernández-Bustillo, et al. 2005 Alpha 1-antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia Med Hypotheses 64 4 759 769 10.1016/j.mehy.2004.10. 005 1:CAS:528:DC%2BD2MXhtVOls7g%3D 15694694 (Pubitemid 40203064)
25. American Thoracic Society 2003 European Respiratory Society Statement: standards for the diagnosis and management of individuals with alpha1-antitrypsin deficiency Am J Respir Crit Care Med 168 818 900 10.1164/rccm.168.7.818 (Pubitemid 37203396)
26. S Janciauskiene T Stevens I Blanco 2007 New insights into the biology of alpha1-antitrypsin and its role in chronic obstructive pulmonary disease Curr Respir Med Rev 3 147 158 1:CAS:528:DC%2BD2sXltFOjsrs%3D
27. P Cordelier DS Strayer 2003 Mechanisms of alpha1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis Biochim Biophys Acta 1638 3 197 207 1:CAS:528:DC%2BD3sXls1Ons7w%3D 12878320
28. L Shapiro GB Pott AH Ralston 2001 Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1 FASEB J 15 1 115 122 10.1096/fj.00-0311com 1:CAS:528:DC%2BD3MXht1SnsLs%3D 11149899 (Pubitemid 32061662)
29. ED Chan AM Kaminska W Gill K Chmura NE Feldman X Bai CM Floyd KE Fulton GA Huitt MJ Strand MD Iseman L Shapiro 2007 Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages Scand J Infect Dis 39 8 690 696 10.1080/00365540701225744 1:CAS:528:DC%2BD2sXotV2lurw%3D 17654345 (Pubitemid 47189022)
30. S Knappstein T Ide MA Schmidt G Heusipp 2004 Alpha 1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains Infect Immun 72 8 4344 4350 10.1128/IAI.72.8.4344-4350.2004 1:CAS:528:DC%2BD2cXmtlynur0%3D 15271889 (Pubitemid 38989289)
31. AM Cantin DE Woods 1999 Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection Am J Respir Crit Care Med 160 4 1130 1135 1:STN:280:DyaK1MvjvFyhsQ%3D%3D 10508798
32. WB Lushbaugh AB Kairalla AF Hofbauer P Arnaud JR Cantey FE Pittman 1981 Inhibition of Entamoeba histolytica cytotoxin by alpha 1 antiprotease and alpha 2 macroglobulin Am J Trop Med Hyg 30 3 575 585 1:CAS:528:DyaL3MXltV2rurw%3D 6167173
33. JR Forney S Yang MC Healey 1997 Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin Antimicrob Agents Chemother 41 9 2006 2008 1:CAS:528:DyaK2sXlvFOgurc%3D 9303402
34. FJ De Serres I Blanco E Fernández-Bustillo 2007 PI S and PI Z alpha-1 antitrypsin deficiency worldwide. A review of existing genetic epidemiological data Monaldi Arch Chest Dis 67 4 184 208 18309698
35. B Gooptu DA Lomas 2009 Conformational pathology of the serpins: themes, variations, and therapeutic strategies Annu Rev Biochem 78 147 176 10.1146/annurev.biochem.78.082107.133320 1:CAS:528:DC%2BD1MXos1Ghtbw%3D 19245336
36. I Blanco E Fernández MC Rodríguez A Fernández 1999 Allelic frequency of the gene of alpha-1-antitrypsin in the general population in a county in Asturias Med Clin (Barc) 113 10 366 370 1:STN:280: DC%2BD3c%2FivVKkug%3D%3D
37. I Blanco E Fernández 2001 Alpha1-antitrypsin Pi phenotypes S and Z in Spain: An analysis of the published surveys Respir Med 95 2 109 114 10.1053/rmed.2000.0964 1:STN:280:DC%2BD3M7islejtg%3D%3D 11217906 (Pubitemid 32624441)
38. R Aldonyte S Eriksson E Piitulainen A Wallmark S Janciauskiene 2004 Analysis of systemic biomarkers in COPD patients COPD 1 2 155 164 10.1081/COPD-120030828 17136983
39. MR Amel Kashipaz D Swinden I Todd RJ Powell 2003 Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells Clin Exp Immunol 132 2 360 365 10.1046/j.1365-2249.2003.02149.x 1:STN:280:DC%2BD3s7otFaluw%3D%3D 12699429 (Pubitemid 36560636)
40. I Kaufmann C Eisner P Richter V Huge A Beyer A Chouker G Schelling M Thiel 2007 Lymphocyte subsets and the role of TH1/TH2 balance in stressed chronic pain patients Neuroimmunomodulation 14 5 272 280 10.1159/000115041 1:CAS:528:DC%2BD1cXislSlsrw%3D 18239379 (Pubitemid 351339994)
41. I Kaufmann G Schelling C Eisner HP Richter A Beyer T Krauseneck A Chouker M Thiel 2008 Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia Rheumatol Int 29 1109 1111 10.1007/s00296-008-0803-5 19052753 1:CAS:528:DC%2BD1MXmslyhsrw%3D
42. R Aldonyte L Jansson E Piitulainen S Janciauskiene 2003 Circulating monocytes from healthy individuals and COPD patients Respir Res 4 11 10.1186/1465-9921-4-11 14624669 (Pubitemid 41358098)
43. DA Zisman SL Kunkel RM Strieter WC Tsai K Bucknell J Wilkowski TJ Standiford 1997 MCP-1 protects mice in lethal endotoxemia J Clin Invest 99 12 2832 2836 10.1172/JCI119475 1:CAS:528:DyaK2sXktV2qtLY%3D 9185504
44. RN Gomes RT Figueiredo FA Bozza P Pacheco RT Amâncio AP Laranjeira HC Castro-Faria-Neto PT Bozza MT Bozza 2006 Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production Shock 26 5 457 463 10.1097/01.shk. 0000228801.56223.92 1:CAS:528:DC%2BD28Xht1eht7vK 17047515 (Pubitemid 44632274)
45. RW Depaolo R Lathan BJ Rollins WJ Karpus 2005 The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection Infect Immun 73 10 6514 6522 10.1128/IAI.73.10.6514-6522.2005 1:CAS:528: DC%2BD2MXhtVyhurjI 16177325 (Pubitemid 41368815)
46. CL Speyer CL Speyer H Gao NJ Rancilio TA Neff GB Huffnagle JV Sarma PA Ward 2004 Novel chemokine responsiveness and mobilization of neutrophils during sepsis Am J Pathol 165 6 2187 2196 1:CAS:528:DC%2BD2MXhs1Kmtg%3D%3D 15579460
47. RD Ramnath SW Ng A Guglielmotti M Bhatia 2008 Role of MCP-1 in endotoxemia and sepsis Int Immunopharmacol 8 6 810 818 10.1016/j.intimp.2008.01. 033 1:CAS:528:DC%2BD1cXls1Sgs74%3D 18442784
48. AN Kalehua JE Nagel LM Whelchel JJ Gides RS Pyle RJ Smith JW Kusiak DD Taub 2004 Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration Exp Cell Res 297 1 197 211 10.1016/j.yexcr.2004.02.031 1:CAS:528:DC%2BD2cXkvVKmsbg%3D 15194436 (Pubitemid 38759573)
49. E Lund SA Kendall B Janerot-Sjoberg A Bengtson 2003 Muscle metabolism in fibromyalgia studied by P-31 magnetic resonance spectroscopy during aerobic and anaerobic exercise Scand J Rheumatol 32 138 145 10.1080/03009740310002461 1:STN:280:DC%2BD3szlvFejtg%3D%3D 12892249 (Pubitemid 36819377)
50. M Jeschonneck G Graohman H Hein H Sprott 2000 Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia Rheumatology (Oxford) 39 8 917 921 10.1093/rheumatology/39.8.917 1:STN:280:DC%2BD3cvntFWqsA%3D%3D (Pubitemid 30649522)
51. Y Kasahara RM Tuder CD Cool DA Lynch SC Flores NF Voelkel 2001 Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema Am J Respir Crit Care Med 163 3 Pt 1 737 744 1:STN:280:DC%2BD3M3itFGlsw%3D%3D 11254533
52. AG Richter EO Maughan GD Perkins N Nathani DR Thickett 2005 VEGF levels in pulmonary fibrosis Thorax 60 2 171 10.1136/thx.2004.031500 1:STN:280:DC%2BD2M%2FlsVejsQ%3D%3D 15681510
53. TP Gavin HW Stallings 3rd KA Zwetsloot LM Westerkamp NA Ryan RA Moore WE Pofahl RC Hickner 2005 Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans J Appl Physiol 98 1 315 321 10.1152/japplphysiol.00353.2004 1:CAS:528:DC%2BD2MXotFGgtQ%3D%3D 15298982 (Pubitemid 40041262)
54. AN Croley KA Zwetsloot LM Westerkamp NA Ryan AM Pendergast RC Hickner WE Pofahl TP Gavin 2005 Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women J Appl Physiol 99 5 1872 1879 10.1152/japplphysiol.00498.2005 1:CAS:528: DC%2BD2MXht1CrtbfE 16024519 (Pubitemid 41547186)
55. F Togo BH Natelson GH Adler JE Ottenweller DL Goldenberg ZR Struzik Y Yamamoto 2008 Plasma cytokine fluctuations over time in healthy controls and patients with fibromyalgia Exp Biol Med (Maywood) 234 232 240 10.3181/0808-RM-254 1:CAS:528:DC%2BD1MXhvVWqsrY%3D
56. RA Silva MS Gomes R Appelberg 2000 Minor role played by type I tumour necrosis factor receptor in the control of Mycobacterium avium proliferation in infected mice Immunology 99 203 207 10.1046/j.1365-2567.2000.00937.x 1:CAS:528:DC%2BD3cXhsVKksrY%3D 10692037 (Pubitemid 30093664)
57. IK Campbell K O'Donnell KE Lawlor P Ian 2001 Wicks severe inflammatory arthritis and lymphadenopathy in the absence of TNF J Clin Invest 107 12 1519 1527 10.1172/JCI12724 1:CAS:528:DC%2BD3MXksFeqsLk%3D 11413159